Results 191 to 200 of about 6,088 (246)

Identifying gut microbial signatures associated with B cells and tertiary lymphoid structures (TLS) in the tumor microenvironment (TME) in response to immune checkpoint blockade (ICB).

Journal of Clinical Oncology, 2022
2511 Background: While ICB has significantly improved clinical outcomes across several cancer types, only 15-20% of patients develop a durable response. Thus, novel and targetable biomarkers are needed. There is increased appreciation of the role of the gut microbiome, and TLS and B-cells in the TME in response to ICB.
Elise F Nassif, Manoj Chelvanambi, Lili Chen, Chia-Chin Wu, Ashish Damania, Emily Zhi-Yun Keung, Russell G. Witt, Michael White, Nadim J. Ajami, Matthew C. Wong, Neeta Somaiah, Boris Sepesi, Sreyashi Basu, James Patrick Allison, Padmanee Sharma, Kevin McBride, Wolf-Hervé Fridman, Jennifer Ann Wargo, Tina Cascone, Christina Lynn Roland   +19 more
openaire   +1 more source

Significance of intratumoral tertiary lymphoid structure (TLS) as predictictive factors of nivolumab therapy after conversion surgery for unresectable gastric cancer: A retrospective study.

Journal of Clinical Oncology, 2020
412 Background: Conversion surgery for unresectable advanced gastric cancer has been increasing with the development of chemotherapy. Adjuvant chemotherapy regimens after conversion surgery have not been standardized. The main mechanism of nivolumab is augmentation of antitumor immune response of tumor infiltrating cytotoxic T cells (CTL) to cancer ...
Hiroaki Tanaka, Takuya Mori, Kenjiro Kimura, Kazuya Muguruma, Kosei Hirakawa, Masaichi Ohira   +5 more
openaire   +1 more source

Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy

Nature Communications
The discovery of tertiary lymphoid structures (TLS) within tumor tissues provides a promising avenue to promote the efficacy of cancer immunotherapy. Yet, the lack of effective strategies to induce TLS formation poses a substantial obstacle.
Liang Zhang, Boxin Zhang, Meng‐Jie Zhang, Wenlang Li, Hao Li, Yantian Jiao, Qi-Chao Yang, Shuo Wang, Yuan-Tong Liu, A. Song, Hai‐Tao Feng, Jianwei Sun, Ryan T. K. Kwok, J. Lam, B. Tang, Zhi-jun Sun   +15 more
semanticscholar   +1 more source

Radiotherapy-derived engineered stem cell exosomes improve anti-glioma immunotherapy by promoting the formation of tertiary lymphoid structure and improve the release of type I interferon

Journal of Nanobiotechnology
The absence of signaling pathways related to intrinsic immune activation in tumor cells and the immunosuppressive microenvironment limit lymphocyte infiltration, constitutes an “immune-desert” tumor displaying insensitivity to various immunotherapies ...
Man Li, Lisen Lu, Qiuhong Bao, Minghui Zhou, Bin Nie, Yanchao Liu, K. Shu, Ting Lei, Mingxin Zhu   +8 more
semanticscholar   +1 more source

Identifying the potential therapeutic targets of tertiary lymphoid structure in IgA nephropathy based on bioinformatics

Autoimmunity
Studies have found that there is tertiary lymphoid structure (TLS) in IgA nephropathy (IgAN), and the existence of TLS has an impact on renal function, creatinine, and proteinuria in patients.
Mengxiao Zou, Dan Yang, Han Xu, Shuwang Ge   +3 more
semanticscholar   +1 more source

Exploring effects of gut microbiota on tertiary lymphoid structure formation for tumor immunotherapy

Frontiers in Immunology
Anti-tumor immunity, including innate and adaptive immunity is critical in inhibiting tumorigenesis and development of tumor. The adaptive immunity needs specific lymph organs such as tertiary lymphoid structures (TLSs), which are highly correlated with ...
Yuqing Liu, Fan Li, Juanjuan Wang, Rongcun Yang   +3 more
semanticscholar   +1 more source

Abstract P2-08-47: Evaluation of stromal tumor-infiltrating lymphocytes (sTIL) and tertiary lymphoid structures (TLS) in early breast cancer patients with triple negative breast cancer(TNBC) included in a prospective study of neoadjuvant chemotherapy (NAC) with Epirubicin and cyclophosphamide (EC) and carboplatin-paclitaxel (PC) (BSMO 2014-01)

Cancer Research, 2019
Abstract Background: BSMO 2014-01 is a completed prospective phase 2 study evaluating the efficacy of neoadjuvant EC and PC. One of the secondary endpoints was the correlation of sTIL with response, pCR and survival. We also assessed the relationship between sTIL and TLS in the diagnostic biopsies.
C Fontaine, G Van den Eynden, R de Wind, A Boisson, V Renard, H Van den Bulck, P Vuylsteke, P Glorieux, C Dopchie, L Decoster, J De Grève, A Awada, H Wildiers, K Willard-Gallo   +13 more
openaire   +1 more source

A comprehensive evaluation of gene expression-based signatures for detecting tertiary lymphoid structures (TLS) in metastatic renal cell carcinoma (mRCC).

Journal of Clinical Oncology
591 Background: TLS are organized lymphoid aggregates linked to improved response to immunotherapy in multiple cancers, including mRCC. Traditionally, TLS assessment relies on pathological staining of tumor sections.
Eddy Saad, Nourhan El Ahmar, Berkay Simsek, Opeyemi Jegede, Sayed Matar, Razan Assaad Mohanna, Emre Yekeduz, David F. McDermott, Elizabeth R. Plimack, Jeffrey A. Sosman, Naomi Balzer Haas, Michael E. Hurwitz, Hans J. Hammers, Eliezer Mendel Van Allen, Toni K. Choueiri, Michael B. Atkins, Sabina Signoretti, David A. Braun   +17 more
openaire   +1 more source

Interferon Regulatory Factor 4 Recruits Immature B Cells to Signal Tertiary Lymphoid Structure Immaturity and Progression of Clear Cell Renal Cell Carcinoma

International Journal on Biological Sciences
Background: Tertiary lymphoid structures (TLSs), organized clusters of immune cells within non-lymphoid tissues, significantly influence tumor progression and therapeutic response.
Siqi Zhou, Shiqi Ye, Liang Chen, Qintao Ge, Jiahe Lu, Aihetaimujiang Anwaier, X. Tian, Zhongyuan Wang, Shuxuan Zhu, Kun Chang, Jianfeng Yang, Tian Li, Hai-Lang Zhang, Dingwei Ye, Jianfeng Xiang, Wenhao Xu   +15 more
semanticscholar   +1 more source

Correlation analysis of tertiary lymphoid structure parameters with the prognosis of patients with locally advanced rectal cancer after neoadjuvant chemotherapy: a retrospective study

World Journal of Surgical Oncology
The tertiary lymphoid structures (TLSs) are positively correlated with the prognosis of many solid tumors, including colorectal cancer. However, their prognostic significance in patients with locally advanced rectal cancer (LARC) after neoadjuvant ...
Yingjian Jiang, Chuang Zhang, Yifei Hou, Bin Zhao, Binbin Cui   +4 more
semanticscholar   +1 more source