Results 201 to 210 of about 6,088 (246)

Chronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders in mice

Nature Communications
Gaps in knowledge about the epididymal mucosa contribute to the prevalent classification of male idiopathic infertility. Inflammatory triggers, such as infections and autoimmunity, can breach immune privilege, induce anti-sperm antibody (ASA) production,
M. Elizagaray, Ferran Barrachina, M. C. Avenatti, I. Bastepe, Angela Chen, Ainize Odriozola, Oluchi Ukairo, V. D. Da Ros, K. Ottino, N. Subirán, M. Battistone   +10 more
semanticscholar   +1 more source

Dynamic Hydrogel Drug Delivery of mRNA for Enhancing Tertiary Lymphoid Structure Formation and Maturation 2080

Journal of Immunology
Tertiary lymphoid structures (TLSs) are lymphoid-like aggregates within the tumor microenvironment, linked to improved cancer prognosis and enhanced immune responses, including immune checkpoint blockade (ICB) therapies.
Chaiyaporn Kuwentrai, Weilong Tang, Matthew J Webber, Zhou Ye, Jiandong Huang   +4 more
semanticscholar   +1 more source

Abstract PO4-25-04: MHC Class I and II Expression, Functional Tertiary Lymphoid Structure (TLS), and Outcomes in Early-Stage HER2-Positive (HER2+) Breast Cancer in NCCTG N9831 (Alliance)

Cancer Research
Abstract Background: Tertiary lymphoid structure (TLS) is an organized form of ectopic lymphoid aggregates (LA) with secondary lymphoid organ structure. Several studies showed that the presence of TLS associates with improved outcomes in multiple cancers when treated with immune checkpoint inhibitors.
Saranya Chumsri, Tracy Shachner, Zhuo Li, Nadine Norton, Alvaro Moreno-Aspitia, Gerardo Colon-Otero, Edith Perez, Aziza Nassar, E. Thompson, Keith Knutson   +9 more
openaire   +1 more source

A Tertiary Lymphoid Structure-Related Gene Signature Predicts Prognosis and Treatment Response in Hepatocellular Carcinoma

World Journal of Oncology
Background Hepatocellular carcinoma (HCC) carries a poor prognosis with limited treatment options. Tertiary lymphoid structures (TLS) impact tumor immunity, but their role in HCC requires clarification.
Xiang Yin Kong, Xiao Hao Li, Xing Long Qiu, Ming Yu Ma, Jin Hao Liu, Zi Chun Wang, Zi Hui Meng, Shang Wei Ji   +7 more
semanticscholar   +1 more source

B-341 Effect of chemokine CXCL13-induced tertiary lymphoid structure formation on pathological features and prognosis of non-small cell lung cancer

Clinical Chemistry
The prognosis of patients with non-small cell lung cancer (NSCLC) is closely related to the tumor microenvironment. Studies have shown that the status of tertiary lymphoid structures (TLS) is an important factor affecting the tumor microenvironment.
H. Geng, Mengli Xue, Shixiong Li, Meilin Xu   +3 more
semanticscholar   +1 more source

Abstract 3358: Tertiary lymphoid structures (TLS) estimated by AI tools from digital H&E slides significantly enhance survival prediction in high-risk AJCC stages III/IV melanoma

Cancer Research
Abstract Tertiary lymphoid structures (TLS) in tumors have emerged as novel disease prognostic and predictive biomarkers with immunotherapy. Recent advances in whole-slide image (WSI) digitization of pathology slides and AI tools are making in situ prediction of TLS more feasible. Methods:
Ahmad A. Tarhini, Tingyi Li, Ranran Tao, Sandra J. Lee, Islam Eljilany, F. Stephen Hodi, Howard Streicher, Arivarasan Karunamurthy, John M. Kirkwood, Xuefeng Wang   +9 more
openaire   +1 more source

Identifying the antigenic drivers of tertiary lymphoid structure formation in solid cancers 3205

Journal of Immunology
Tertiary Lymphoid Structures (TLSs) are ectopic lymphoid structures, formed in the presence of inflammation/tumors and are niches for antigen drainage. TLSs provide tumor-adjacent compartments to support cognate interactions of T follicular helper (
Mary Melissa Roland, Amy Zhou, Lyubov Kublo, Venkata Krishna Kanth Makani, Paul M. Zdinak, Alok V. Joglekar   +5 more
semanticscholar   +1 more source

702 Tertiary lymphoid structures (TLS) observed in non-small cell lung cancer (NSCLC) tumors treated with pulsed electric fields

Regular and Young Investigator Award Abstracts, 2022
Jeff Iding, Paul VanderLaan, Marcelo Jimenez, José Fernández García-Hierro, Javier Flandes Aldeyturriaga, Erik HFM van der Heijden, Calvin SH Ng, Rainbow WH Lau, Maria Ludeña, Rafael Carías, Oderay Cedeño, Alicia Moreno-Gonzalez, Beryl Hatton, William Krimsky   +13 more
openaire   +1 more source

Artificial Intelligence and Multi-modality Data Integration Deciphers Tertiary Lymphoid Structure Maturity in Gastric Cancer.

Cancer Research
Tertiary lymphoid structures (TLSs) are critical components of the tumor microenvironment in gastric cancer (GC), but clinical assessment of TLS is challenging.
Wenxuan Wu, Zhenzhen Xun, Yaxuan Han, Qimiao Chen, Shaojun Yu, Yikai Luo, Zhixing Hao, Jing Chen, Yewei Xu, Xiaying Han, Jia Qi, Kai Song, Xiaojing Ma, Yongyuan Yhen, Guofeng Chen, Muxing Kang, Xiaoli Jin, Yuan Ding, Zhiqiang Zhu, Can Hu, Xiangdong Cheng, Lie Wang, Pin Wu, Han Liang, Jian Chen   +24 more
semanticscholar   +1 more source

Abstract 3205: Artificial intelligence (AI) -powered H&E whole-slide image (WSI) analysis of tertiary lymphoid structure(TLS) to predict response to immunotherapy in non-small cell lung cancer (NSCLC)

Cancer Research
Background: The efficacy of ICIs in treating NSCLC is limited to a subset of patients, necessitating reliable predictive biomarkers. TLSs within the tumor microenvironment have emerged as potential indicators. This study aims to investigate the association between an AI-powered TLS analysis and treatment response of
Young Kwang Chae, Leeseul Kim, Sangwon Shin, Sooick Cho, Sanghoon Song, Borislav Alexiev, Behtash Nezami   +6 more
openaire   +1 more source