Results 31 to 40 of about 6,088 (246)

Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in MiceSummary

Cellular and Molecular Gastroenterology and Hepatology, 2021
Background and aims: The presence of tertiary lymphoid structures (TLSs) may confer survival benefit to patients with pancreatic ductal adenocarcinoma (PDAC), in an otherwise immunologically inert malignancy.
Francesca R. Delvecchio, Rachel E.A. Fincham, Sarah Spear, Andrew Clear, Marina Roy-Luzarraga, Frances R. Balkwill, John G. Gribben, Michele Bombardieri, Kairbaan Hodivala-Dilke, Melania Capasso, Hemant M. Kocher   +10 more
doaj   +1 more source

Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer [PDF]

, 2022
Immune checkpoint inhibitors (ICI) have provided significant improvement in clinical outcomes for some patients with solid tumors. However, for patients with head and neck cancer, the response rate to ICI monotherapy remains low, leading to the ...
Aro, Katri, Basnet, Saru, Bäck, Leif, Cervera Carrascon, Victor, Clubb, James H. A., Havunen, Riikka, Heinioe, Camilla, Hemminki, Akseli, Kudling, Tatiana V., Loimu, Venla, Pakola, Santeri, Quixabeira, Dafne C. A., Salo, Tuula, Santos, Joao Manuel, Sorsa, Suvi, Tulokas, Sanni, Zheng, Vincent   +16 more
core   +3 more sources

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor immunity, immunosuppression, or Bystander Sentinels in Disease? [PDF]

, 2017
Secondary lymphoid organs are integral to initiation and execution of adaptive immune responses. These organs provide a setting for interactions between antigen-specific lymphocytes and antigen-presenting cells recruited from local infected or ...
Adachi, Ager, Ager, Aloisi, Andrian von, Ansel, Attridge, Avram, Banks, Bell, Bento, Bergomas, Bombardieri, Browning, Buckley, Bénézech, Calcinotto, Carragher, Carrega, Cañete, Chai, Chen, Cipponi, Colbeck, Coles, Contractor, Coppola, Coronella, de Chaisemartin, De Togni, Deteix, Di Caro, Dieu-Nosjean, Dieu-Nosjean, Drayton, Drayton, Eberl, Fan, Fava, Figenschau, Finkin, Foo, Furman, Furtado, Furtado, Förster, Galkina, Gallimore, Gantsev, García-Hernández, Gardner, Gatumu, Germain, Giraldo, Girard, Gobert, Goc, Goc, Gopal, Gräbner, Gu-Trantien, Hamanishi, Hindley, Hiraoka, Hjelmström, Johansson-Percival, Jones, Joshi, Joyce, Katakai, Kirk, Klages, Kocks, Kratz, Kroeger, Ladányi, Lee, Li, Liao, Lochner, Low, Lu, Luther, Luther, Luther, Marinkovic, Martinet, Martinet, Martinet, McMahon, McMullen, Mebius, Mebius, Mebius, Mebius, Meier, Messina, Motallebzadeh, Moussion, Moyron-Quiroz, Moyron-Quiroz, Muramatsu, Neyt, Nielsen, Nishikawa, Nzula, Ohl, Onder, Peske, Peters, Picker, Pitzalis, Randall, Randolph, Rangel-Moreno, Rangel-Moreno, Remark, Rennert, Roozendaal, Rosen, Ruddle, Sakaguchi, Sakai, Sawa, Scheu, Schmutz, Schneider, Schrama, Schrama, Scurr, Seleznik, Shields, Song, Stranford, Sun, Suzuki, Takatori, Teng, van de Pavert, van de Pavert, van de Pavert, Vermeij, Vondenhoff, Walter, Weinstein, Wengner, Winter, Yokota, Yoshida, Yoshida, Yoshida, Yu   +151 more
core   +5 more sources

Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development [PDF]

, 2018
Tertiary lymphoid structures (TLSs) display phenotypic and functional characteristics of secondary lymphoid organs, and often develop in tissues affected by chronic inflammation, as well as in certain inflammation-associated cancers where they are ...
Balic, Jesse J., Bhathal, Prithi S., D'Costa, Kimberley, Ferrero, Richard L., Gallimore, Awen M., Gao, Hugh, Hill, David, Jenkins, Brendan J., Jones, Gareth W., McLeod, Louise, Oshima, Hiroko, Oshima, Masanobu, Sievert, William, West, Alison, Yu, Liang   +14 more
core   +4 more sources

Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation [PDF]

, 2016
Tertiary lymphoid structures (TLS) are organized aggregates of lymphocytes, myeloid, and stromal cells that provide ectopic hubs for acquired immune responses.
Christopher D. Buckley, David H. Gardner, Francesca Barone, Nathalie Steinthal, Saba Nayar, Sanjiv A. Luther   +5 more
core   +3 more sources

Activation of tyrosine kinases by mutation of the gatekeeper threonine. [PDF]

, 2008
Protein kinases targeted by small-molecule inhibitors develop resistance through mutation of the gatekeeper threonine residue of the active site. Here we show that the gatekeeper mutation in the cellular forms of c-ABL, c-SRC, platelet-derived growth ...
Azam, Mohammad, Daley, George, Gray, Nathanael, KURIYAN, John, Seeliger, Markus   +4 more
core   +1 more source

Kidney tertiary lymphoid structures in Lupus Nephritis develop into large interconnected networks and resemble lymph nodes in gene signature [PDF]

, 2020
Immune aggregates organized as tertiary lymphoid structures (TLS) are observed within the kidneys of patients with systemic lupus erythematosus and lupus nephritis (LN).
Dorraji, Seyed Esmaeil, Fenton, Christopher Graham, Fenton, Kristin Andreassen, Figenschau, Stine, Horvei, Kjersti Daae, Hovd, Aud-Malin Karlsson, Kanapathippillai, Premasany, Pedersen, Hege Lynum, Stenersrød, Mikael Ryan, Thiyagarajan, Dhivya Borra, Ursvik, anita   +10 more
core   +1 more source

Prognostic and therapeutic potential of gene profiles related to tertiary lymphoid structures in colorectal cancer [PDF]

PeerJ
The role of tertiary lymphoid structures (TLS) in oncology is gaining interest, particularly in colorectal carcinoma, yet a thorough analysis remains elusive.
Jinglu Yu, Yabin Gong, Xiaowei Huang, Yufang Bao   +3 more
doaj   +2 more sources

Putative Immunological Functions of Inducible Skin-Associated Lymphoid Tissue in the Context of Mucosa-Associated Lymphoid Tissue

Frontiers in Immunology, 2021
Acquired immunity is orchestrated in various lymphoid organs, including bone marrow, thymus, spleen, and lymph nodes in humans. However, mucosa-associated lymphoid tissue (MALT) is evolutionally known to be emerged in the oldest vertebrates as an ...
Toshiaki Kogame, Kenji Kabashima, Gyohei Egawa   +2 more
doaj   +1 more source

DNA repair, DNA replication and human disorders: A personal journey [PDF]

, 2012
I was born in 1946 and grew up in the industrial north-west of England close to the city of Manchester. My parents were German- Jewish refugees, who left Germany fairly early, in 1933.
Alan R. Lehmann, Barnes, Barnes, Bienko, Bohr, Broughton, Burk, Carr, Cleaver, Cordonnier, Daigaku, Domon, Edmunds, Fenech, Fousteri, Gebara, Griffiths, Henderson, Hirano, Hoege, Johnson, Kannouche, Kannouche, Kannouche, Karras, Kleijer, Lee, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lehmann, Lett, Ley, Masutani, Mayne, McDonald, McGrath, Mellon, Murray, Murray, Nduka, Ogi, Okazaki, Palecek, Phipps, Regan, Rupp, Rupp, Saitoh, Savitsky, Schaeffer, Schmickel, Sergeant, Setlow, Stefanini, Strunnikov, Taylor, Taylor, Taylor, Teo, Tissier, Tsukada, van Duin, Venema, Weber   +75 more
core   +1 more source