Results 41 to 50 of about 6,088 (246)
Frontiers in Immunology, 2022 Tertiary lymphoid structure (TLS) and tumor-resident memory T cells (TRM) play crucial roles in the anti-tumor immune response, facilitating a good prognosis in patients with cancer. However, there have been no reports on the relationship between TRM and
Hua Zhao +25 more
doaj +1 more source
Turning an old GADDget into a troublemaker [PDF]
, 2018 Life must continually defend against infection. One of the most ancient types of immunity is the process of active cell death, which first arose in evolution plausibly with protists, as a primordial defence against intracellular ...
C McCormick +21 more
core +1 more source
Does TLS Exist in Canine Mammary Gland Tumours? Preliminary Results in Simple Carcinomas [PDF]
, 2022 : Neoplastic progression is influenced by the expression of tumour antigens that activate an anti-tumour immune response. Human medical studies show that this body defence is carried out in secondary lymphoid organs (SLOs) but also directly in the ...
Alessandra, Sfacteria +7 more
core +1 more source
Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome [PDF]
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial ...
Asam, Saba +23 more
core +9 more sources
B cells in the formation of Tertiary Lymphoid Organs in autoimmunity, transplantation and tumorigenesis. [PDF]
, 2019 TLS develop in target organs of autoimmune diseases, transplantation and cancer. • TLS can function as germinal centres supporting B-cell selection/differentiation.
BOMBARDIERI, M +3 more
core +1 more source
The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer [PDF]
, 2021 Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power.
Broeks, Annegien +16 more
core +1 more source
Myc Cooperates with Ras by Programming Inflammation and Immune Suppression. [PDF]
, 2017 The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRasG12D-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly ...
Brown Swigart, Lamorna +7 more
core +1 more source
Cancer Research, 2018 Abstract Objective: Tertiary lymphoid structures (TLS) are transient ectopic lymphoid aggregates that reflect lymphoid neogenesis mainly through CXCL13 and develop under chronic inflammation. Recently TLS have been detected in several types of cancers; however, there are few reports about TLS in ovarian cancer.
Masayo Ukita +5 more
openaire +1 more source
Human Vaccines & Immunotherapeutics, 2023 This study aimed to investigate the relationship between complete pathological remission (PCR), tertiary lymphoid structure (TLS) maturation and expression and clinical outcomes of patients with resectable non-small cell lung cancer (NSCLC) receiving ...
Ying Liu +12 more
doaj +1 more source
Fibroblasts in Sjögren’s Syndrome [PDF]
, 2021 The Sjögren’s syndrome is an autoimmune disease characterized by chronic inflammation of the exocrine glands, leading to dryness of mucosal surfaces, and often to severe systemic manifestations.
Klein, Kerstin
core +2 more sources