Results 51 to 60 of about 6,088 (246)

504 Using multiplexed immunofluorescence to quantitatively analyze myeloid derived suppressor cells (MDSCs) in relation to tertiary lymphoid structures (TLS) in bladder cancer

Regular and young investigator award abstracts, 2020
Background An intriguing phenomenon in many solid tumors is the de novo lymphoid neogenesis of tertiary lymphoid structure (TLS). However, it remains unclear whether spontaneous TLS restricts or promotes tumor progression. MDSCs are major contributors to tumor evasion of adaptive immune responses.
Xin Lu, Anna Juncker-Jensen, Gang Huang, Mate Nagy   +3 more
openaire   +2 more sources

Tertiary lymphoid structures in head and neck squamous cell carcinoma

Translational Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide. Smoking, drinking, and human papillomavirus (HPV) infection are the main risk factors.
Jing Zhu, Hui Lu, Kongcheng Wang, Baorui Liu, Jing Yan   +4 more
doaj   +1 more source

Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer

OncoImmunology, 2021
Immunotherapy that block PD-1–PD-L1 pathway can induce durable tumor control and result in the long-term survival of patients with advanced bladder cancers. However, these responses only occur in a subset of patients. We study gene expression profiles in
Lin Zhou, Bin Xu, Yushan Liu, Zhong Wang
doaj   +1 more source

Tertiary lymphoid structures and gastric cancer prognosis [PDF]

, 2022
Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and high diameter have been shown to be associated with prognosis in different cancer types.
Böhm, Jan, Helminen, Olli, Junttila, Anna, Kauppila, Joonas H., Kemi, Niko, Mrena, Johanna, Väyrynen, Juha P., Ylitalo, Olli   +7 more
core   +1 more source

The prognostic value of the tertiary lymphoid structure in gastrointestinal cancers

Frontiers in Immunology, 2023
BackgroundNumerous studies and research papers have provided evidence suggesting that tertiary lymphoid structures (TLS) play a crucial role in combating and suppressing tumor growth and progression.
Aoyang Yu, Menghan Cao, Kaile Zhang, Yule Yang, Luyao Ma, Xinran Zhang, Yang Zhao, Xiao Ma, Zhixiang Fan, Zhengxiang Han, Hongmei Wang   +10 more
doaj   +1 more source

Patterns of tumor infiltrating lymphocytes in adenoid cystic carcinoma of the head and neck [PDF]

, 2022
Adenoid cystic carcinoma (ACC) is a rare malignancy in the head and neck. The prognosis remains poor and late recurrences often occur after 5 years and later. To date, there are no reliable prognostic markers for ACC.
Arolt, Christoph, Bankfalvi, Agnes, Bastian, Tobias, Brunner, Cornelia, Doescher, Johannes, Hoffmann, Thomas K., Klußmann, Jens Peter, Laban, Simon, Lang, Stephan, Meyer, Moritz, Quaas, Alexander, Schildhaus, Hans-Ulrich, Schuler, Patrick J., Weissinger, Stephanie E., Wolber, Philipp   +14 more
core   +1 more source

Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring

Frontiers in Immunology
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies. However, conflicting reports underscore the need to consider TLS heterogeneity and multiple features such as TLS size, composition, and maturation status, when assessing their functional impact.
Julie Berthe, Pawan Poudel, Felix J. Segerer, Emily C. Jennings, Felicia Ng, Michael Surace, Alma Andoni, Marco Testori, Megha Saraiya, Miljenka Vuko, Harald Hessel, Mari Heininen-Brown, Jorge Blando, Emma V. Jones, Sophie E. Willis, Jérôme Galon, Jérôme Galon, Jérôme Galon, Rieneke van de Ven, Rieneke van de Ven, Rieneke van de Ven, Tanja D. de Gruijl, Tanja D. de Gruijl, Tanja D. de Gruijl, Helen K. Angell   +24 more
openaire   +4 more sources

Additional file 1 of Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary Materials. Table S1. Quality assessment details for included studies. Table S2. Summary of controlled covariates in multivariate analyses. Figure S1. Sensitivity analysis for TLS with OS in digestive system cancers patients. Figure S2.
Sun, Hao, Shi, Yuanyu, Ran, Hailiang, Peng, Junwei, Li, Qiongxian, Zheng, Guiqing, He, Yandie, Liu, Shuqing, Chang, Wei, Xiao, Yuanyuan   +9 more
openaire   +1 more source

Tumor-Infiltrating Lymphocytes (TIL), Tertiary Lymphoid Structures (TLS), and Expression of PD-1, TIM-3, LAG-3 on TIL in Invasive and In Situ Ductal Breast Carcinomas and Their Relationship with Prognostic Factors

Clinical Breast Cancer, 2022
Immunotherapy has been determined as an important choice in breast carcinomas, especially in tumors with markedly inflammatory response. About this promising subject, tumor-infiltrating lymphocytes (TIL) and the expression of immune control point receptors on TIL have gained importance.In this study, stromal TIL and tertiary lymphoid structures (TLS ...
Elif Acar, Güldal Esendağlı, Ozan Yazıcı, Ayşe Dursun   +3 more
openaire   +4 more sources

The clinical significance of tertiary lymphoid structure and its relationship with peripheral blood characteristics in patients with surgically resected non-small cell lung cancer: A single-center, retrospective study [PDF]

, 2022
博士（医学 ...
Fukuhara, Mitsuro, 福原, 光朗
core   +1 more source