Results 71 to 80 of about 6,088 (246)

CXCL9 and CXCL13 shape endometrial cancer immune‐activated microenvironment via tertiary lymphoid structure formation

Cancer Science
Immune checkpoint inhibitor (ICI) therapy has been successfully applied to various cancers; however, not all patients respond to ICI therapy. Tumors with an immune‐activated environment are highly responsive to ICIs.
Yoshihiro Nagase, Makoto Kodama, E. Aimono, Kohei Nakamura, Reika Takamatsu, Keiko Abe, Takuma Yoshimura, T. Chiyoda, Wataru Yamagami, Hiroshi Nishihara   +9 more
semanticscholar   +1 more source

CXC Chemokine‐Driven Vascular Reprogramming: Modulating Tumor Vasculature to Boost Therapeutic Response

Advanced Science, EarlyView.
Tumor vascular remodeling is discussed from a chemokine‐centered perspective. This review summarizes the bidirectional, temporal, and tissue‐specific roles of CXC chemokines in regulating vascular function and immune accessibility. A functional vascular normalization score is introduced as a conceptual framework to integrate dynamic vascular and immune
Hongdan Chen, Yinde Huang, Juntong Wu, Ziying Yi, Yao Li, Zeyu Yang, Fan Zhang, Chong Li   +7 more
wiley   +1 more source

CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis.

Cancer Cell
Tertiary lymphoid structures (TLSs) are associated with enhanced immunity in tumors. However, their formation and functions in colorectal cancer liver metastasis (CRLM) remain unclear.
Yifan Zhang, Guangjian Liu, Qianwen Zeng, Wenrui Wu, K. Lei, Chuankai Zhang, Miaoling Tang, Yuting Zhang, Xiao Xiang, Li Tan, Rui Cui, Si Qin, Xinming Song, Changjun Yin, Zhihang Chen, Ming Kuang   +15 more
semanticscholar   +1 more source

Mature Tertiary Lymphoid Structures Indicate Good Chemotherapy Response and Prognosis in Advanced Colorectal Cancer

Annals of Gastroenterological Surgery, EarlyView.
In advanced colorectal cancer, tumors with mature tertiary lymphoid structures (TLS) exhibited abundant infiltration of CD3‐ and CD8‐positive lymphocytes in both primary and metastatic sites, indicating an activated immune response. The presence of mature TLS was also associated with favorable chemotherapy sensitivity and improved prognosis.
Nobuhiro Hosoi, Chika Komine, Gendensuren Dorjkhorloo, Takuya Shiraishi, Takuhisa Okada, Akihiko Sano, Makoto Sakai, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

Tertiary Lymphoid Structures as Independent Predictors of Favorable Prognosis in Muscle‐Invasive Bladder Cancer

Cancer Medicine
Background Tertiary lymphoid structure (TLS) has been reported to be associated with prognosis and immunotherapy in certain cancers. The objective of our study was to investigate the prognostic significance of Tertiary Lymphoid Structures (TLS) within ...
Xiaodong Teng, Zhen Chen, Yanfeng Bai, Hui Cao, Jing Zhang, Liming Xu, Kaihua Liu, Yuqian Shi, Yang Shao   +8 more
doaj   +1 more source

The tertiary lymphoid structure-related signature identified PTGDS in regulating PD-L1 and promoting the proliferation and migration of glioblastoma

Heliyon
Background: Tertiary lymphoid structure (TLS) is a unique organ that carries out tumor cell elimination at tumor sites. It is continuously stimulated by inflammatory tumor signals and has been found to augment immunotherapy response.
Wantao Wu, He Li, Zeyu Wang, Ziyu Dai, Xisong Liang, Peng Luo, Kun Liu, Hao Zhang, Nan Zhang, Shuyu Li, Chi Zhang   +10 more
doaj   +1 more source

Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma [PDF]

, 2014
BACKGROUND: Oral squamous cell carcinomas are often heavily infiltrated by immune cells. The organization of B-cells, follicular dendritic cells, T-cells and high-endothelial venules into structures termed tertiary lymphoid structures have been detected ...
Hadler-Olsen, Elin Synnøve, Rikardsen, Oddveig G, Steigen, Sonja Eriksson, Uhlin-Hansen, Lars, Wirsing, Anna Maria   +4 more
core   +2 more sources

An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure

Cell Reports Medicine
Summary The immune responses during the initiation and invasion stages of human lung adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single-cell RNA sequencing map to decipher the immune dynamics during human LUAD development.
Wei Liu, Wenhua You, Zhenwei Lan, Yijiu Ren, Shuangshu Gao, Shuchao Li, Wei-wei Chen, Chunyu Huang, Yong Zeng, Nengming Xiao, Zeshuai Wang, Huikang Xie, Huan Ma, Yun Chen, Guangsuo Wang, Chang Chen, Hanjie Li   +16 more
semanticscholar   +1 more source

Engineering Tertiary Lymphoid Structures: Nanomedicine, Bioengineering, and Biomaterials for Precision Immunotherapy

Advanced NanoBiomed Research, EarlyView.
This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley   +1 more source

Review: radiotherapy-mediated B cells within the TLS influence the tumor microenvironment

Journal for ImmunoTherapy of Cancer
The tumor microenvironment (TME) is a diverse and intricate structure consisting of tumor cells, stromal cells, endothelial cells, and immune cells. It is characterized by the communication between tumor cells and both innate and adaptive immune cells ...
Haihua Yang, Dandan Zhou, Kuifei Chen, Yinan Meng, Ziran Chen, Yixiu Xu, Suna Zhou, Xiaozhi Zhang   +7 more
doaj   +1 more source