Results 81 to 90 of about 6,088 (246)

Pan-cancer analysis of genomic properties and clinical outcome associated with tumor tertiary lymphoid structure

Scientific Reports, 2020
How the genomic landscape of a tumor shapes the formation of tertiary lymphoid structure (TLS) and how might TLS alter the clinical outcome or response to immunotherapy had not been systematically explored. Utilizing the genomic and transcriptome data of
Ziying Lin, Lixia Huang, ShaoLi Li, Jincui Gu, Xiaoxian Cui, Yanbin Zhou   +5 more
doaj   +1 more source

Stratification of chronic rhinosinusitis with nasal polyps by distinct sinonasal microbial communities and their clinical and pathological correlations

iMetaOmics, EarlyView.
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory condition. Dysbiosis is commonly observed. This study identified distinct sinonasal microbial communities in CRSwNP patients and explored their clinical and pathological associations. Two distinct microbial communities were identified: community type 1 (CT1), dominated by
Bixing Fang, Yanmin Liu, Qing Bao, Lin Sun, Hexin Chen, Qingxiang Meng, Linyi Jiao, Xiaoyan Ye, Jian Li, Tao Ding, Chunwei Li   +10 more
wiley   +1 more source

Tertiary lymphoid structures in esophageal cancer: a novel target for immunotherapy

Frontiers in Immunology
Esophageal cancer (EC), especially esophageal squamous cell carcinoma (ESCC), which is the most common subtype in China, is one of the most aggressive gastrointestinal malignancies. Traditional treatments like surgery, radiotherapy, and chemotherapy have
Ke Zhai, Yuting Ma, Xue Gao, Kun Ru, Miaoqing Zhao   +4 more
doaj   +1 more source

Combination of Tertiary Lymphoid Structure and Neutrophil-to-Lymphocyte Ratio Predicts Survival in Patients With Hepatocellular Carcinoma

Frontiers in Immunology, 2022
BackgroundHepatocellular carcinoma (HCC) is the most common pathological type of primary liver cancer. The lack of prognosis indicators is one of the challenges in HCC.
Shaodi Wen, Yuzhong Chen, Chupeng Hu, Xiaoyue Du, Jingwei Xia, Xin Wang, Wei Zhu, Qingbo Wang, Miaolin Zhu, Yun Chen, Yun Chen, Yun Chen, Bo Shen   +12 more
doaj   +1 more source

Multi-resolution deep learning characterizes tertiary lymphoid structures and their prognostic relevance in solid tumors [PDF]

BACKGROUND Tertiary lymphoid structures (TLSs) are dense accumulations of lymphocytes in inflamed peripheral tissues, including cancer, and are associated with improved survival and response to immunotherapy in various solid tumors.
Ciompi, Francesco, Moch, Holger, Obahor, Simon, Pagliarulo, Fabio, Schraml, Peter, Silina, Karina, van den Broek, Maries, van der Laak, Jeroen, van Rijthoven, Mart   +8 more
core   +1 more source

Preoperative VEGFR‐TKI Plus ICI Therapy Facilitates 3D‐Guided Cytoreductive Nephron‐Sparing Surgical Feasibility and Immune Remodeling in Advanced Renal Cell Carcinoma

Med Research, EarlyView.
Preoperative VEGFR‐TKI plus ICI therapy in advanced ccRCC normalizes tumor vasculature, enhances CD8⁺ T/B cell infiltration, and promotes TLS maturation, leading to profound tumor microenvironment remodeling. These immunologic changes improve the feasibility of 3D reconstruction‐guided robotic cytoreductive nephron‐sparing surgery, resulting in reduced
Wenhao Xu, Aihetaimujiang Anwaier, Qintao Ge, Siqi Zhou, Xi Tian, Shuxuan Zhu, Guohai Shi, Yu Zhu, Dingwei Ye, Mierxiati Abudurexiti, Hailiang Zhang   +10 more
wiley   +1 more source

Impact of Tertiary Lymphoid Structure on Prognosis and Tumor Microenvironment in Undifferentiated Pleomorphic Sarcoma

Cancer Science
Undifferentiated pleomorphic sarcoma (UPS) has a favorable objective response rate to anti‐PD‐1 drugs compared with other sarcomas. Tertiary lymphoid structure (TLS) is a favorable prognostic factor and a biomarker for immune checkpoint inhibitors (ICIs).
Hiroki Sonoda, Takeshi Iwasaki, S. Ishihara, Taro Mori, Y. Nakashima, Y. Oda   +5 more
semanticscholar   +1 more source

T‐Cell Immunity and Lung Cancer

Respirology, EarlyView.
ABSTRACT Lung cancer remains a leading cause of cancer mortality worldwide. Although immune checkpoint inhibitors (ICIs) have reshaped therapeutic strategies in lung cancer, their benefits remain limited. ICIs exert their therapeutic efficacy by activating T‐cell effector functions, underscoring the central role of T cells in antitumor immunity.
Kotaro Yamada, Yosuke Togashi
wiley   +1 more source

Neoadjuvant Therapy‐Induced Remodeling in Pancreatic Ductal Adenocarcinoma: Multimodal Spatial Analysis and Prognosis

Cancer Science, EarlyView.
Using integrated spatial pathomics and transcriptomics, we show that neoadjuvant therapy (NAT) in pancreatic ductal adenocarcinoma (PDAC) induces substantial tumor microenvironment remodeling that is not captured by tumor regression grading (TRG) alone.
Xiaofei Zhang, Ruoxin Lan, Danting Li, Yongjun Liu, Sonu Kalyan, Momin Iqbal, Nancy Liu, Jerry Zhang, Iman Hanna, Mala Gupta, Chaohui L. Zhao, Weiguo Liu, Jonathan Melamed, Michael Shusterman, Jessica Widmer, John Allendorf, Yao‐Zhong Liu   +16 more
wiley   +1 more source

Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis

Science Advances
Tertiary lymphoid structures (TLSs) usually lead to significantly improved clinical benefits in immunotherapy but are rarely observed within native tumors.
Ran Cheng, Sucheng Li, Xianbin Ma, Wanru Zhuang, Yao Lei, Jiaqi He, Chao Liang, Weidong Nie, Haiyan Xie   +8 more
semanticscholar   +1 more source