Results 121 to 130 of about 212,593 (289)

A multivariate Th17 metagene for prognostic stratification in T cell non-inflamed triple negative breast cancer

OncoImmunology, 2019
A diversity of T helper (Th) subsets (Th1, Th2, Th17) has been identified in the human tumor microenvironment. In breast cancer, the role of Th subsets remains controversial, and a systematic study integrating Th subset diversity, T cell inflammation ...
L. Faucheux, M. Grandclaudon, M. Perrot-Dockès, P. Sirven, F. Berger, A.S. Hamy, V. Fourchotte, A. Vincent-Salomon, F. Mechta-Grigoriou, F. Reyal, A. Scholer-Dahirel, M. Guillot-Delost, V. Soumelis   +12 more
doaj   +1 more source

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization

OncoImmunology, 2018
D-2-hydroxyglutarate (D-2HG) is released by various types of malignant cells including acute myeloid leukemia (AML) blasts carrying isocitrate dehydrogenase (IDH) gain-of-function mutations.
Martin Böttcher, Kathrin Renner, Raffaela Berger, Kristin Mentz, Simone Thomas, Zugey Elizabeth Cardenas-Conejo, Katja Dettmer, Peter J. Oefner, Andreas Mackensen, Marina Kreutz, Dimitrios Mougiakakos   +10 more
doaj   +1 more source

Th17 profile in COPD exacerbations

International Journal of Chronic Obstructive Pulmonary Disease, 2017
COPD is characterized by an ongoing inflammatory process of the airways that leads to obstruction or limitation of airflow. It is mainly associated with exposure to cigarette smoke. In addition, it is considered, at present, a serious public health problem, ranking fourth in mortality worldwide.
Marco Ponce-Gallegos, Alejandra Ramírez-Venegas, Ramcés Falfán-Valencia   +2 more
openaire   +5 more sources

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Next-Generation Therapeutics for Perianal Fistulizing Crohn’s Disease: The Anticipated Impact of IL-23 Inhibitors

Hail Journal of Health Sciences
Background: Perianal fistulizing Crohn’s disease (PFCD) remains a formidable complication of Crohn’s disease (CD), affecting up to 30%–50% of patients and associated with significant morbidity.
Alfadl Abdulfattah
doaj   +1 more source

An increased expression profile of Th9/IL-9 correlated with Th17/IL-17 in patients with immune thrombocytopenia

Platelets, 2017
Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th9 cells were recently identified as a new subtype of Th cells, characterized by preferential production of IL-9.
Jianlin Qiao, Xiaoqian Li, Yulu Wu, Xiaoqing Wu, Feng Zhu, Na Liu, Kunming Qi, Hai Cheng, Depeng Li, Haiying Sun, Lingyu Zeng, Kailin Xu   +11 more
doaj   +1 more source

Th17 Cells [PDF]

The American Journal of Pathology, 2012
Mohan S. Maddur, Pierre Miossec, Srini V. Kaveri, Jagadeesh Bayry   +3 more
openaire   +1 more source

Glucuronolactone Promotes Mucin Sulfation to Alleviate Deoxynivalenol‐Induced Intestinal Injury via Microbiota‐Dependent and ‐Independent AHR Activation

Advanced Science, EarlyView.
Glucuronolactone (GLU) as a natural metabolite of glucose, increases Lactobacillus amylovorus abundance and luminal IAA level to activate AHR signaling. In addition, GLU itself can directly elevate AHR signaling activity independently of microbiota and IAA.
Chenbin Cui, Beibei Zhang, Jiaxi Tang, Jing Hou, Yueqin Qiu, Kaiguo Gao, Li Wang, Zongyong Jiang, Xuefen Yang   +8 more
wiley   +1 more source

Polymorphisms in Th17-related genes and the pathogenesis of autoimmune thyroid disease

Autoimmunity, 2018
The prognosis of autoimmune thyroid disease (AITD) including Graves’ disease (GD) and Hashimoto’s disease (HD) is difficult to predict. We previously suggested that Th17 cells may be associated with the pathogenesis of AITD.
Takayuki Kunisato, Mikio Watanabe, Naoya Inoue, Azusa Okada, Takashi Nanba, Wataru Kobayashi, Yuka Inoue, Yuka Katsumata, Naoki Omori, Takayuki Nobuhara, Kazuya Takemura, Yoh Hidaka, Yoshinori Iwatani   +12 more
doaj   +1 more source