Results 161 to 170 of about 260,137 (386)

HLA Class II Antibody Activation of Endothelial Cells Promotes Th17 and Disrupts Regulatory T Lymphocyte Expansion [PDF]

, 2015
Julien Lion, Cécile Taflin, Amy Cross, Macarena Robledo-Sarmiento, Elena Mariotto, Alain Savenay, M. Carmagnat, Caroline Suberbielle, Dominique Charron, Alain Haziot, Denis Glotz, Nuala Mooney   +11 more
openalex   +1 more source

L’augmentation du pourcentage de lymphocytes Th17 est associée à un risque d’évolution vers une forme grave d’infection à SARS-CoV-2

, 2022
M. Samson, Barbara Nicolas, A Guilhem, Hélène Greigert, Marion Ciudad, Claudie Cladière, Cécile Straub, Mathieu Blot, Lionel Piroth, T. Rogier, H. Devilliers, Patrick Manckoundia, Thibault Ghesquière, S. Francois, Daniela Lakomy, Sylvain Audia, Bernard Bonnotte   +16 more
openalex   +2 more sources

Differential Regulation of Human Treg and Th17 Cells by Fatty Acid Synthesis and Glycolysis

Frontiers in Immunology, 2019
In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells.
D. Cluxton, A. Petrasca, B. Moran, J. Fletcher   +3 more
semanticscholar   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source

Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection

Cells, 2019
Background: Schistosomiasis is an immunopathogenic disease in which Th17 cells play vital roles. Hepatic granuloma formation and subsequent fibrosis are its main pathologic manifestations and the leading causes of hepatic cirrhosis, and effective ...
Wei Zhou, Yingying Yang, Congjin Mei, Panpan Dong, Shasha Mu, Hongchu Wu, Yonghua Zhou, Yi Zheng, Fukun Guo, Jun-Qi Yang   +9 more
doaj   +1 more source

Pre‐Existing Th1 Immunity Outperforms Age in Predicting Antibody Responses to SARS‐CoV‐2 Inactivated Vaccines

Advanced Science, EarlyView.
Challenging the focus on age, this study finds pre‐existing T helper 1 cells are the key biomarker for predicting antibody response to SARS‐CoV‐2 inactivated vaccines. In both mice and humans, high responders exhibited elevated baseline T helper 1 cells, which correlated with robust humoral immunity, offering crucial guidance for improving vaccine ...
Chanyuan Ye, Xiaoli Zhang, Lingfeng Qiu, Jia Ji, Jueqing Gu, Hongyu Jia, Yingfeng Lu, Jiyang Chen, Zelu Meng, Jiangshan Lian, Hangping Yao, Xun Zeng, Yida Yang   +12 more
wiley   +1 more source

Altered peripheral blood Th17 and follicular T-helper subsets in patients with pulmonary tuberculosis

Инфекция и иммунитет, 2019
Tuberculosis (TB) is one of the most common infections worldwide. Eradication of an intracellular pathogen M. tuberculosis requires to induce a Th1 response by activating IFNγ-producing tissue macrophages.
I. V. Kudryavtsev, M. K Serebriakova, A. A. Starshinova, Yu. S. Zinchenko, N. Yu. Basantsova, E. N. Belyaeva, M. V. Pavlova, P. K. Yablonskiy   +7 more
doaj   +1 more source

Extracts from Seseli mairei Wolff attenuate imiquimod-induced psoriasis-like inflammation by inhibiting Th17 cells [PDF]

, 2023
Mengmeng Wang, Xunqing Yin, Yongcheng Zeng, Chunyan Hu, Yongmei Xue, Qionglian Fang, Xue Qiao, Xiujuan Zhao, Chenghong Du, Feng Huang, Yuping Lin   +10 more
openalex   +1 more source

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

Cancer immunology research, 2018
The Treg/Th17 ratio is altered in epithelial ovarian cancer. Exosomal miRNAs from tumor-associated macrophages contribute to this T-cell imbalance, which promotes an immune suppressive tumor microenvironment and favors progression and metastasis of ...
Jieru Zhou, Xiaoduan Li, Xiaoli Wu, Ting Zhang, Qinyi Zhu, Xinjing Wang, Husheng Wang, Kai Wang, Yingying Lin, Xipeng Wang   +9 more
semanticscholar   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source