Results 11 to 20 of about 235,232 (245)

Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides [PDF]

Journal of Experimental Medicine, 2006
Th17 cells are a distinct lineage of effector CD4+ T cells characterized by their production of interleukin (IL)-17. We demonstrate that Th17 cells also expressed IL-22, an IL-10 family member, at substantially higher amounts than T helper (Th)1 or Th2 ...
Spencer C. Liang, X. Tan, D. Luxenberg, Riyez Karim, K. Dunussi-joannopoulos, M. Collins, L. Fouser   +6 more
semanticscholar   +2 more sources

The Endogenous Th17 Response in NO2-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer [PDF]

, 2013
Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease.
A Abe, A Duguet, A Hoshino, A Vazquez-Tello, A Vazquez-Tello, AG Besnard, AG Besnard, AI Caceres, AJ Coyle, AR Brasier, AR Sousa, AS Saffar, AT Hastie, B Korkmaz, Benjamin T. Suratt, BJ Canning, C Sutton, C Taube, D Stejskal, Daniel J. Weiss, DB Corry, DC Newcomb, DC Newcomb, DC Newcomb, DH Broide, E Goleva, F Kirstein, GJ Zijlstra, H Fujie, H Koga, H Wakashin, Hong Wei Chu, I Tillie-Leblond, J Agbetile, J Chang, J Seok, J Sunyer, J Zhao, JB Cowland, Jennifer L. Ather, JH Bates, JH Lee, JL Ather, JL Ather, John F. Alcorn, JR Karlsen, JV Fahy, K Raemdonck, K Yang, L McKinley, LA Cooney, Laura Hoyt, Lennart K. A. Lundblad, LJ Akinbami, LK Lundblad, LK Lundblad, LK Lundblad, LL Reber, M Bevelander, M Kawaguchi, M Kudo, M Leppkes, M Suzukawa, MA Willart, Matthew E. Poynter, ME Poynter, ME Poynter, ME Poynter, MH Brutsche, MH Shaw, MW Kinyanjui, N Schmitz, PA Wark, PL Delamater, PS Foster, PW Hellings, Q Wang, R He, RA Martin, Rebecca A. Martin, Rebecca Daggett, RH Wilson, S Ano, S Dragon, S Ferretti, S Haak, S Lajoie, S Molet, S Schnyder-Candrian, S Suzuki, S Wenzel, SJ Ballantyne, SM Hu, SP Chapoval, SR Hodgkins, T Li, VJ Johnson, W Al-Ramli, WP Arend, WW Lee, X Yao, XY Chi, Y Chung, Y Liu, Y Takenoue, Y Zhao, YH Wang   +106 more
core   +14 more sources

Intricacies of TGF-β signaling in Treg and Th17 cell biology

Cellular & Molecular Immunology, 2023
Balanced immunity is pivotal for health and homeostasis. CD4^+ helper T (Th) cells are central to the balance between immune tolerance and immune rejection. Th cells adopt distinct functions to maintain tolerance and clear pathogens.
Junying Wang, Xingqi Zhao, Y. Wan
semanticscholar   +1 more source

The role of Th17 cells in inflammatory bowel disease and the research progress

Frontiers in Immunology, 2023
Th17 cells play an important role in the abnormal immune response in inflammatory bowel disease (IBD) and are involved in the development and progression of inflammation and fibrosis. An increasing amount of data has shown that gut microbes are important
Lu Chen, Guangcong Ruan, Yi Cheng, Ailin Yi, Dongfeng Chen, Yanling Wei   +5 more
semanticscholar   +1 more source

Human gut bacteria produce TH17-modulating bile acid metabolites

bioRxiv, 2021
The microbiota plays a pivotal role in gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17a (TH17 cells).
Donggi Paik, Lina Yao, Yancong Zhang, Sena Bae, G. D’Agostino, Eunha Kim, E. Franzosa, J. Ávila-Pacheco, J. Bisanz, Christopher K. Rakowski, H. Vlamakis, R. Xavier, P. Turnbaugh, R. Longman, Michael R Krout, C. Clish, C. Huttenhower, Jun R. Huh, A. Devlin   +18 more
semanticscholar   +1 more source

Lactate induces metabolic and epigenetic reprogramming of pro‐inflammatory Th17 cells

EMBO Reports, 2022
Increased lactate levels in the tissue microenvironment are a well‐known feature of chronic inflammation. However, the role of lactate in regulating T cell function remains controversial.
Aleksandra Lopez Krol, Hannah P Nehring, Felix F. Krause, Anne Wempe, H. Raifer, Andrea Nist, T. Stiewe, W. Bertrams, B. Schmeck, Maik Luu, Hanna Leister, Ho-Ryun Chung, U. Bauer, Till Adhikary, A. Visekruna   +14 more
semanticscholar   +1 more source

The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases

Frontiers in Immunology, 2021
Chronic inflammation plays an important role in the development of metabolic diseases. These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty liver disease.
Siwen Zhang, X. Gang, Shuo Yang, Mengzhao Cui, Lin Sun, Zhuo Li, Guixia Wang   +6 more
semanticscholar   +1 more source

Bile acid metabolites control Th17 and Treg cell differentiation

bioRxiv, 2018
Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is ...
Saiyu Hang, Donggi Paik, Lina Yao, Eunha Kim, Jamma Trinath, Jingping Lu, Soyoung Ha, Brandon N. Nelson, Samantha P. Kelly, Lin Wu, Ye Zheng, R. Longman, F. Rastinejad, A. Devlin, Michael R Krout, M. Fischbach, D. Littman, D. Littman, Jun R. Huh, Jun R. Huh   +19 more
semanticscholar   +2 more sources

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]

, 2009
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core   +1 more source

Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression. [PDF]

, 2017
Granulocyte-macrophage colony-stimulating factor (GM-CSF) produced by T helper 17 (Th17) cells plays an essential role in autoimmune diseases. Transcriptional regulation of Th17 cell differentiation has been extensively studied, but post-transcriptional ...
Adamiak, William, Atasoy, Ulus, Chen, Jing, Huang, Ganlei, Rostami, Abdolmohamad M., Yu, Shiguang   +5 more
core   +3 more sources