COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles
Molecules, 2017 Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used therapeutic agents that exhibit frequent and sometimes severe adverse effects, including gastrointestinal ulcerations and cardiovascular disorders.
S. Oniga +7 more
semanticscholar +1 more source
Green synthesis of highly functionalized octahydropyrrolo[3,4-c]pyrrole derivatives using subcritical water, and their anti(myco)bacterial and antifungal activity [PDF]
, 2018 A series of novel 2-(thiazol-2-yl)-octahydropyrrolo[3,4-c]pyrroles was synthesized by reaction of octahydropyrrolo[3,4-c]pyrrole N-benzoylthiourea derivatives and α-haloketones in subcritical water at 130 °C in 75-91% yield.
De Coen, Laurens +4 more
core +1 more source
Self‐Calibrating Ratiometric DNA Aptamer Probe for Quantitative ATP Imaging in Living Cells
Chemistry – A European Journal, EarlyView.We developed the RFA–ECHO probe, an internally calibrated ATP sensor that remains responsive across millimolar ATP levels. Its self‐correcting Cy5/ECHO ratio ensures accurate quantification independent of probe uptake. Compared with FRET‐based sensors, it yields a robust ratiometric shift, distinguishing high‐ATP cancer cells from normal ones, enabling
Yunsong Xu +5 more
wiley +1 more source
N-Propargylamines: versatile building blocks in the construction of thiazole cores
Beilstein Journal of Organic Chemistry, 2017 Thiazoles and their hydrogenated analogues are not only key structural units in a wide variety of natural products but they also constitute important building blocks in medicinal chemistry.
S. Arshadi +4 more
doaj +1 more source
The thiazole and triazole derivatives as inhibitors of metal corrosion: Part I
Zaštita Materijala, 2016 This review is a result of the literature survey concerning the possibility of inhibition of steel and aluminum alloy corrosion in different conditions using organic compounds.
Jelena Nakomčić, Đenđi Vaštag
doaj +1 more source
Thiazole-Bearing 4-Thiazolidinones as New Anticonvulsant Agents
Scientia Pharmaceutica, 2020 Here, we describe the synthesis and anticonvulsant activity of thiazole-bearing hybrids based on 2-imino-4-thiazolidinone and 2,4-dioxothiazolidine-5-carboxylic acid cores.
Mariia Mishchenko +3 more
doaj +1 more source
A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety
Chemistry Central Journal, 2017 BackgroundThiazoles and 1,3,4-thiadiazoles have been reported to possess various pharmacological activities.ResultsA novel series of thiazoles carrying 1,3,4-thiadiazole core were designed and prepared via the reaction of the 2-(4-methyl-2-phenylthiazole-
Sobhi M. Gomha +4 more
semanticscholar +1 more source
Inhibition of PaCaMKII-E isoform in the dorsal unpaired median neurosecretory cells of cockroach reduces nicotine- and clothianidin-induced currents [PDF]
, 2014 Cellular responses to Ca(2+) require intermediary proteins such as calcium/calmodulin-dependent protein kinase II (CaMKII), which transduces the signal into downstream effects.
D. Calas-List +5 more
core +4 more sources
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Mid‐Infrared Spectroscopy and Machine Learning for Chlorogenic Acid Quantification in Coffee
Chemie Ingenieur Technik, EarlyView.Chlorogenic acid (CGA) concentration in coffee was predicted using mid‐infrared (MIR) spectroscopy and a machine learning approach. Forty‐four roasting stages (140–220 °C) plus a green coffee control were analyzed. A multilayer perceptron regressor, trained on preprocessed MIR data, outperformed traditional peak analysis, enabling accurate and ...
Deborah Herdt +6 more
wiley +1 more source