Thiopurine S -methyltransferase polymorphisms: efficient screening method for patients considering taking thiopurine drugs [PDF]
European Journal of Clinical Pharmacology, 2018 Objective: More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs.
Fried, M. +5 more
core +4 more sources
Thiopurine S-Methyltransferase and Methylenetetrahydrofolate Reductase Polymorphisms in Leukemia [PDF]
Turkish Journal of Hematology, 2015 Serhan Küpeli
doaj +2 more sources
Association between Thiopurine S-Methyltransferase Polymorphisms and Azathioprine-Induced Adverse Drug Reactions in Patients with Autoimmune Diseases: A Meta-Analysis. [PDF]
PLoS ONE, 2015 Azathioprine (AZA) is widely used as an immunosuppressive drug in autoimmune diseases, but its use is limited by significant adverse drug reactions (ADRs). Thiopurine S-methyltransferase (TPMT) is an important enzyme involved in AZA metabolism.
Yue-Ping Liu +6 more
doaj +2 more sources
Association of thiopurine S-methyltransferase and NUDT15 polymorphisms with azathioprine-induced myelotoxicity in Chinese patients with rheumatological disease [PDF]
Chinese Medical Journal, 2020 Song-Sen Su +3 more
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Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients. [PDF]
Ann Dermatol, 2017 Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. TPMT genotyping is widely used for screening of AZA-related toxicity during routine clinical practice in Korea.
Lee M, Seo J, Bang D, Kim DY.
europepmc +5 more sources
Thiopurine S-methyltransferase and Pemphigus Vulgaris: A Phenotype-Genotype Study. [PDF]
Iran J Pathol, 2020 Thiopurine drugs are considered as a treatment modality in various autoimmune disorders including pemphigus vulgaris (PV). These drugs are metabolized by an enzyme "Thiopurine S-methyl transferase" (TPMT). Various variants of this enzyme may have decreased activity leading to serious drug side effects.
Mokhtari M +5 more
europepmc +4 more sources
Pharmacogenetics-based personalized treatment in patients with inflammatory bowel disease: A review [PDF]
Precision and Future Medicine, 2021 The development of treatment options has revolutionized the prognosis of inflammatory bowel disease (IBD). However, a particular group of patients still experience therapeutic failure or drug side effects.
Ji Young Chang, Jae Hee Cheon
doaj +1 more source
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology [PDF]
The Journal of Clinical InvestigationPurine nucleotides are critical for nucleic acid synthesis, signaling, and cellular metabolism. Thiopurines (TPs), including 6-mercaptopurine and 6-thioguanine, are cornerstone agents for the treatment of acute lymphoblastic leukemia (ALL).
Leo Kager, Kaan Boztug
doaj +2 more sources
Thiopurine S-Methyltransferase as a Pharmacogenetic Biomarker: Significance of Testing and Review of Major Methods. [PDF]
Cardiovasc Hematol Agents Med Chem, 2017 Asadov C, Aliyeva G, Mustafayeva K.
europepmc +2 more sources
gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease [PDF]
Intestinal Research, 2020 Thiopurine has been used to maintain remission and to reduce antidrug antibody formation in monoclonal antibody therapy in patients with inflammatory bowel disease (IBD). The use of thiopurine is limited by side effects such as leukopenia.
Katsuyoshi Matsuoka
doaj +1 more source