Economic Evaluation of Pharmacogenetic Tests in Patients Subjected to Renal Transplantation: A Review of Literature [PDF]
, 2016 Renal transplantation is the treatment of choice for the patients with end-stage renal failure. Genetic factors, among others, can influence variability in response to immunosuppressive drugs.
Aleksandra Kovacevic +5 more
core +2 more sources
Gene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms? [PDF]
PLoS ONE, 2013 BACKGROUND AND AIMS: Thiopurines are effective to induce and maintain remission in inflammatory bowel disease (IBD). The methyl thioinosine monophosphate (meTIMP)/6-thioguanine nucleotide (6-TGN) concentration ratio has been associated with drug efficacy.
Sofie Haglund +3 more
doaj +1 more source
Common Polymorphism’s Analysis of Thiopurine S-Methyltransferase (TPMT) in Iranian Population [PDF]
Cell Journal, 2009 Objective: Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurinedrugs. Low activity phenotypes are correlated with several mutations in the TPMTgene and adverse drug reactions.
Mehdi Azad +4 more
doaj
Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]
, 2010 Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer +18 more
core +2 more sources
Methylation of selenocysteine catalysed by thiopurine S-methyltransferase
Biochimica et Biophysica Acta (BBA) - General Subjects, 2019 Methylation driven by thiopurine S-methylatransferase (TPMT) is crucial for deactivation of cytostatic and immunosuppressant thiopurines. Despite its remarkable integration into clinical practice, the endogenous function of TPMT is unknown.To address the role of TPMT in methylation of selenium compounds, we established the research on saturation ...
Urbančič, Dunja +7 more
openaire +3 more sources
Influence of genetic variants in TPMT and COMT associated with cisplatin induced hearing loss in patients with cancer: two new cohorts and a meta-analysis reveal significant heterogeneity between cohorts. [PDF]
PLoS ONE, 2014 Treatment with cisplatin-containing chemotherapy regimens causes hearing loss in 40-60% of cancer patients. It has been suggested that genetic variants in the genes encoding thiopurine S-methyltransferase (TPMT) and catechol O-methyltransferase (COMT ...
Melanie M Hagleitner +10 more
doaj +1 more source
Ars Pharmaceutica, 2023 A 6-year-old girl diagnosed with intermediate-risk acute lymphoblastic leukemia (ALL) presented with severe myelotoxicity and multiple infections during phase IB induction treatment with 6-mercaptopurine (6-MP).
Laura Elena Pineda-Lancheros +5 more
doaj +1 more source
Scientometric mapping as a strategic intelligence tool for the governance of emerging technologies [PDF]
, 2014 How can scientometric mapping function as a tool of ’strategic intelligence’ to aid the governance of emerging technologies? The present paper aims to address this question by focusing on a set of recently developed scientometric techniques, namely ...
Hopkins, Michael +3 more
core +2 more sources
Individualized therapy: Role of thiopurine S-methyltransferase protein and genetic variants [PDF]
Journal of Medical Biochemistry, 2010 Thiopurine S-methyltransferase (TPMT: EC 2.1.1.67) is an enzyme that metabolizes immunosuppressive thiopurine medications, used in the treatment of autoimmune diseases, cancer and in transplantation medicine.
Pavlović Sonja, Zukić Branka
doaj
Nomenclature for alleles of the thiopurine methyltransferase gene [PDF]
, 2013 The drug-metabolizing enzyme thiopurine methyltransferase (TPMT) has become one of the best examples of pharmacogenomics to be translated into routine clinical practice.
Ameyaw +53 more
core +2 more sources