Results 61 to 70 of about 5,310 (212)
Traditional Chinese medicine combination therapy for patients with steroid-dependent ulcerative colitis: study protocol for a randomized controlled trial [PDF]
, 2017 SPIRIT 2013 Checklist: recommended items to address in a clinical trial protocol and related documents.
Hong Shen +6 more
core +3 more sources
Pediatric Blood &Cancer, Volume 73, Issue 4, April 2026.ABSTRACT Introduction Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. The pro‐drug 6‐mercaptopurine (6‐MP), essential during maintenance, is converted into active 6‐thioguanine (6‐TGN) and toxic 6‐methylmercaptopurine (6‐MMP) metabolites, resulting in marked variability in efficacy and toxicity.
Anne Ravix +5 more
wiley +1 more source
Therapeutics and Clinical Risk Management, 2023 Jennifer Gallardo-Cóndor,1 Pablo Naranjo,1 Sebastián Atarihuana,1 Dayana Coello,2 Patricia Guevara-Ramírez,3 Rodrigo Flores-Espinoza,4 Germán Burgos,5,6 Andrés López-Cortés,7,8 Alejandro Cabrera-Andrade9,10 1Facultad de Ingeniería y Ciencias Aplicadas ...
Gallardo-Cóndor J +8 more
doaj
Azathioprine-Induced Peripheral T Cell Apoptosis And Drug Response In Patients With Crohn’s Disease [PDF]
, 2011 Background and Aim: the long time interval for a trial of thioupurine therapy and the potential side effects in spite of the proven efficacy, do not encourage their use as early therapeutic option in Crohn’s Disease (CD).
Cossu, Andrea
core
Carcinogenic Medications: A Review of Specific Agents and Molecular Mechanisms of Carcinogenesis
Cancer Reports, Volume 9, Issue 4, April 2026.ABSTRACT Background Pharmacovigilance has revealed an alarming correlation between certain medications and a higher risk of cancer. In this narrative review, included research from 2020 to 2025, along with a few seminal older studies, so that it provides a clear picture of which drugs actually set off cancer and mechanisms involved at the molecular ...
Desta Seyoum Tadesse +5 more
wiley +1 more source
Turkish Journal of Hematology, 2014 Myelosuppression is a serious complication during treatment of acute lymphoblastic leukemia and the duration of myelosuppression is affected by underlying bone marrow failure syndromes and drug pharmacogenetics caused by genetic polymorphisms.
Burcu Fatma Belen +5 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Introduction: Genetic variation in the thiopurine S-methyltransferase (TPMT) gene by and large predicts variability in 6-mercaptopurine (6-MP) related toxicities.
Awol Mekonnen Ali +6 more
doaj +1 more source
Structural term extraction for expansion of template-based genomic queries [PDF]
, 2005 This paper describes our experiments run to address the ad hoc task of the TREC 2005 Genomics track. The task topics were expressed with 5 different structures called Generic Topic Templates (GTTs). We hypothesized the presence of GTT-specific structural
Blott, Stephen +4 more
core
Drug metabolizing enzyme activities versus genetic variances for drug of clinical pharmacogenomic relevance [PDF]
, 2011 Enzymes are critically important in the transportation, metabolism, and clearance of most therapeutic drugs used in clinical practice today. Many of these enzymes have significant genetic polymorphisms that affect the enzyme's rate kinetics.
Alan H B Wu
core +2 more sources
World Journal of Gastroenterology, 2010 To evaluate the relationship between thiopurine S-methyltransferase (TPMT) polymorphisms and thiopurine-induced adverse drug reactions (ADRs) in inflammatory bowel disease (IBD).Eligible articles that compared the frequency of TPMT polymorphisms among thiopurine-tolerant and -intolerant adult IBD patients were included.
Xian-Wen, Dong +4 more
openaire +2 more sources