Results 21 to 30 of about 5,310 (212)

Optimizing thiopurine therapy in children with acute lymphoblastic leukemia: A promising “MINT” sequencing strategy and therapeutic “DNA-TG” monitoring

Frontiers in Pharmacology, 2022
Thiopurines, including thioguanine (TG), 6-mercaptopurine (6-MP), and azathioprine (AZA), are extensively used in clinical practice in children with acute lymphoblastic leukemia (ALL) and inflammatory bowel diseases.
Hong-Li Guo, Yue-Tao Zhao, Yue-Tao Zhao, Wei-Jun Wang, Wei-Jun Wang, Na Dong, Na Dong, Ya-Hui Hu, Yuan-Yuan Zhang, Feng Chen, Li Zhou, Tao Li   +11 more
doaj   +1 more source

Very important pharmacogene summary: thiopurine S-methyltransferase. [PDF]

Pharmacogenet Genomics, 2010
Thiopurine S-methyltransferase (TPMT, S-adenosyl-L-methionine : thiopurine S-methyltransferase; EC 2.1.1.67) catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (6-MP) and azathioprine as well as other aromatic and heterocyclic sulfhydryl compounds [1,2].Weinshilboum and ...
Wang L, Pelleymounter L, Weinshilboum R, Johnson JA, Hebert JM, Altman RB, Klein TE.   +6 more
europepmc   +4 more sources

Thiopurine-S-Methyltransferase Gene Polymorphism and Drug-related Toxicity in Children Treated for Acute Leukemia and Non-Hodgkin’s Lymphoma

Journal of Pediatric Research, 2022
Aim:Thiopurine S-methyltransferase (TPMT) is an essential enzyme in the metabolism of thiopurine drugs, and its activity may change due to different polymorphisms in the TPMT gene.
Eda Ataseven, Buket Kosova, Çağdaş Aktan, Zafer Kurugöl, Mehmet Kantar   +4 more
doaj   +1 more source

Importance of genotyping of Thiopurine S-methyltransferase in children with acute lymphoblastic leukaemia during maintenance therapy [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2008
INTRODUCTION Thiopurine S-methyltransferase (TPMT) is an enzyme that catalyses the inactivation of mercaptopurine (MP) which is widely used in the treatment of acute lymphoblastic leukaemia (ALL) of childhood.
Dokmanović Lidija, Janić Dragana, Krstovski Nada, Zukić Branka, Tošić Nataša, Pavlović Sonja   +5 more
doaj   +1 more source

Economic evaluations of pharmacogenetic and pharmacogenomic screening tests : a systematic review : second update of the literature [PDF]

, 2016
Objective : Due to extended application of pharmacogenetic and pharmacogenomic screening (PGx) tests it is important to assess whether they provide good value for money. This review provides an update of the literature. Methods : A literature search was
Annemans, Lieven, Berm, Elizabeth JJ, Boersma, Cornelis, de Looff, Margot, Postma, Maarten J, van Boven, Job FM, Vegter, Stefan, Wilffert, Bob   +7 more
core   +9 more sources

A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population

BMC Research Notes, 2022
Objective The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to decreased thiopurine S ...
Kok-Siong Poon, Izz Irfan B. Imran, Silvester Kheng-Han Chew, Patrice Tan, Karen Mei-Ling Tan   +4 more
doaj   +1 more source

Genetic polymorphism of thiopurine S-methyltransferase in Argentina [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2003
Background: Thiopurine methyltransferase (TPMT) catalyses the S-methylation of 6-thiopurine drugs, which are commonly used in the treatment of autoimmune diseases, leukaemia and organ transplantation. TPMT activity is polymorphic as a result of gene mutations.
L E, Laróvere, R Dodelson, de Kremer, L H J, Lambooy, R A, De Abreu   +3 more
openaire   +2 more sources

LC–MS/MS Method for Measurement of Thiopurine Nucleotides (TN) in Erythrocytes and Association of TN Concentrations With TPMT Enzyme Activity

Frontiers in Pharmacology, 2022
Monitoring concentrations of thiopurine metabolites is used clinically to prevent adverse effects in patients on thiopurine drug therapy. We developed a LC–MS/MS method for the quantification of 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) in ...
Amol O. Bajaj, Mark M. Kushnir, Mark M. Kushnir, Erik Kish-Trier, Rachel N. Law, Lauren M. Zuromski, Alejandro R. Molinelli, Gwendolyn A. McMillin, Gwendolyn A. McMillin, Kamisha L. Johnson-Davis, Kamisha L. Johnson-Davis   +10 more
doaj   +1 more source

Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED, MANALK RASHEED, HASANEIN H GHALI   +2 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source