Results 91 to 100 of about 111,761,865 (181)

Small Extracellular Vesicle‐Derived Nidogen 1 Promotes HCC Carcinogenesis via Transglutaminase 3‐Mediated YAP/TAZ Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
NID1‐rich sEVs released by HCC cells are internalized by recipient cells, where the C‐terminal region of NID1 binds to and stabilizes TGM3. This activates integrin‐FAK/Src/AKT and Hippo‐YAP/TAZ signalling, thereby promoting HCC proliferation, colony formation, migration, invasion, tumour growth, and lung metastasis.
Cherlie Lot Sum Yeung, Le Cui, Jingyi Wang, Ching‐Ping Chan, Tung Him Ng, Charlotte Jiaqi Lai, Xiaowen Mao, Sze Keong Tey, Michael Shing Yan Huen, Judy Wai Ping Yam   +9 more
wiley   +1 more source

Multi-autoantibody Signature and Clinical Outcome in Membranous Nephropathy

, 2020
Patients with membranous nephropathy can have circulating autoantibodies against membrane-bound (phospholipase A2 receptor 1 [PLA2R1] and thrombospondin type-1 domain containing 7A [THSD7A]) and intracellular (aldose reductase, SOD2, and α-enolase ...
Prunotto, Marco, Antonella Radice, Zaghrini, Christelle, Christine Payre ́, Barbara Seitz-Polski, Marco Prunotto, Maurizio Bruschi, Seitz-Polski, Barbara, Vaglio, Augusto, Gérard Lambeau, Dolla, Guillaume, Christine Payré, Antonello Pani, Gian Marco Ghiggeri, Scolari, Francesco, Ghiggeri, Gian, Marco, Joana Justino, Guillaume Dolla, Bruschi, Maurizio, Sinico, Alberto, Augusto Vaglio, Radice, Antonella, Vesna Brglez, Alberto Sinico, 2 Vesna Brglez, Giovanni Candiano, Brglez, Vesna, Collaborator, Ge ́rard Lambeau, Gesualdo, Loreto, Justino, Joana, Candiano, Giovanni, Francesco Scolari, Christelle Zaghrini, Ghiggeri, Gian Marco, Justino J, Bruschi M, Prunotto M, Seitz-Polski B, Ghiggeri G.M, Sinico A, Ghiggeri, Gian,, Lambeau G, Scolari F, Vaglio, A, Dolla G, Zaghrini C, Payré C, Radice A, Payré, Christine, Vaglio A, Ghiggeri GM, Lambeau, Gerard, Brglez V, Candiano G, Lambeau G.   +55 more
core   +1 more source

Treatment of primary membranous nephropathy: where are we now? [PDF]

, 2018
In the last 10 years, basic science and clinical research have made important contributions to the understanding and management of primary membranous nephropathy (MN). The identification of antibodies directed against the M-type phospholipase A2 receptor
Angioi A, Lepori N, Sethi S, Pani A., López AC, Fervenza FC   +5 more
core   +1 more source

Multivalent Bi‐Specific Nanoerythrosomes: A Two‐Birds‐One‐Stone Approach to Combine Homologous and Active Targeting for Effective Thrombolysis

Small, Volume 22, Issue 47, 21 August 2026.
A multivalent bi‐specific nanoerythrosome (mBiNE@tPA) is developed as a “two‐birds‐one‐stone” platform that simultaneously exploits two principal thrombus components. By integrating erythrocyte membrane‐mediated homologous targeting with cRGD‐based active targeting to activated platelets, mBiNE@tPA achieves enhanced thrombus accumulation, triggered ...
Yu Huang, Yilin Yang, Nicole Henry, Boram Gu, Jiahua Wang, Yuanyuan Guo, Colin Longstaff, Simon A. Thom, Yuehua Li, Xiao Yun Xu, Rongjun Chen   +10 more
wiley   +1 more source

A FERM domain autoregulates Drosophila myosin 7a activity

, 2009
Full-length Drosophila myosin 7a (myosin 7a-FL) has a complex tail containing a short predicted coiled coil followed by a MyTH4-FERM domain, an SH3 domain, and a C-terminal MyTH4-FERM domain.
Chen, M, Peckham, M, Knight, PJ, Sellers, JR, Baboolal, TG, Walker, ML, Yang, Y, Siththanandan, V   +7 more
core   +1 more source

The Synthetic Melanocortin Agonist NDP‐MSH Ameliorates THSD7A‐Associated Membranous Nephropathy in an Active Immunization Mouse Model

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang, Mengxuan Chen, Yan Ge, William Gunning, Rujun Gong   +4 more
wiley   +1 more source

New tools for autoimmune kidney disease: Design of antigen binding proteins against the thrombospondin type‐1 containing domain 7A

The FASEB Journal, 2019
Idiopathic membranous nephritis, (IMN) is an autoimmune disease (AD) affecting the kidney. Conventional treatment for AD uses immunosuppressive medicines that suppress the entire immune system, rather than target specific autoimmune disorder antibodies. This causes patients to become immunocompromised, and at risk of not being able
Serena Daniella Stoddard, Shana Victoria Stoddard   +1 more
openaire   +1 more source

THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage [PDF]

, 2016
Background and Purpose A ruptured intracranial aneurysm (IA) is the leading cause of a subarachnoid hemorrhage (SAH). This study seeks to define a specific gene whose mutation leads to disease.
DePalma, Steven R., McDonough, Barbara, Hergenroeder, Georgene W., Fang, Xiaoqian, Santiago-Sim, Teresa, Hennessy, Morgan L., Nalbach, Stephen V., Lee, Ming Sum, Greenway, Steven C.   +8 more
core   +1 more source

Immune-Monitoring Disease Activity in Primary Membranous Nephropathy

Frontiers in Medicine, 2019
Primary membranous nephropathy (MN) is a glomerular disease mediated by autoreactive antibodies, being the main cause of nephrotic syndrome among adult patients. While the pathogenesis of MN is still controversial, the detection of autoantibodies against
Paolo Cravedi, Marta Jarque, Andrea Angeletti, Àlex Favà, Chiara Cantarelli, Oriol Bestard, Oriol Bestard   +6 more
doaj   +1 more source

Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites

, 2018
Fibrillar collagens of the extracellular matrix are critical for tissue structure and physiology; however, excessive or abnormal deposition of collagens is a defining feature of fibrosis.
Arkadiusz M. Bonna (16660719), Nicholas Pugh (16653642), Josephine C. Adams (16660725), Silvia Rosini (8987945), Richard W. Farndale (7580165), David J. S. Hulmes (16660722)   +5 more
core   +2 more sources