Results 71 to 80 of about 111,761,865 (181)

Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis [PDF]

Journal of Human Genetics, 2008
Twins and family studies have shown that genetic factors are important determinants of bone mass. Important aspects of bone mineral density (BMD) regulation are endocrine systems, notably hormonal regulation of adrenal corticoids, as indicated by clinical knowledge of glucocorticoid-induced osteoporosis.
Seijiro, Mori, Ikuyo, Kou, Hidenori, Sato, Mitsuru, Emi, Hideki, Ito, Takayuki, Hosoi, Shiro, Ikegawa   +6 more
openaire   +2 more sources

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Activation of transforming growth factor beta by malaria parasite-derived metalloproteinases and a thrombospondin-like molecule [PDF]

, 2003
Much of the pathology of malaria is mediated by inflammatory cytokines (such as interleukin 12, interferon gamma, and tumor necrosis factor alpha), which are part of the immune response that kills the parasite.
Riley, Eleanor M, Sultan, Ali A, J. Brian de Souza, de Souza, J Brian, Eleanor M. Riley, Corran, Patrick H, Patrick H. Corran, Omer, Fakhreldin M, Riley, EM, Sultan, AA, Corran, PH, Ali A. Sultan, Omer, FM, de Souza, JB, Fakhreldin M. Omer   +14 more
core   +1 more source

Idiopathic membranous nephropathy: Evolution in understanding the problem [PDF]

Терапевтический архив, 2016
The review highlights the evolution of ideas on the mechanisms responsible for the development of membranous nephropathy (MN), glomerulopathy that is the most common cause of nephrotic syndrome in adults. Primary emphasis is placed on the primary form of
I N Bobkova, P A Kakhsurueva, E V Stavrovskaya   +2 more
doaj  

Evolution in the understanding of idiopathic membranous nephropathy pathogenesis: from experimental models to the clinic

Alʹmanah Kliničeskoj Mediciny, 2018
Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. This review describes a 60-year history of MN study and represents an evolution in the understanding of its pathogenesis from experimental models to the clinic.
I. N. Bobkova, P. A. Каkhsurueva, E. V. Stavrovskaya, E. E. Filatova   +3 more
doaj   +1 more source

Diagnostic performance of glomerular PLA2R and THSD7A antibodies in biopsy confirmed primary membranous nephropathy in South Africans

BMC Nephrology, 2021
Background: Serum and tissue-based tests using phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain containing 7A (THSD7A) are established immune biomarkers for the diagnosis of primary membranous nephropathy (PMN).
Bingileki F Lwezaula, Oluwatoyin I Ameh, Udeme E Ekrikpo, Francois CJ Botha, Ugochi S Okpechi-Samuel, Nicola Wearne, Pierre Ronco, Aminu K Bello, Ikechi G. Okpechi   +8 more
doaj   +1 more source

MicroRNA‐Mediated Placental Maladaptation in Preeclampsia Pathogenesis

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Graphical representation of miRNA‐mediated placental maladaptation in preeclampsia. Under normal pregnancy conditions, balanced expression of beneficial miRNAs (miR‐126‐3p, miR‐18a/b‐5p, miR‐144‐3p, miR‐378a‐5p, and miR‐146a‐5p) promotes trophoblast proliferation, migration and invasion, spiral artery remodeling, angiogenesis, mitochondrial function ...
Sarbani Saha, Rupasri Ain
wiley   +1 more source

Circulating Antibodies against Thrombospondin Type-I Domain-Containing 7A in Chinese Patients with Idiopathic Membranous Nephropathy

, 2017
Background and objectives Thrombospondin type-I domain containing 7A (THSD7A) was recently identified as the target antigen in about 10% of patients with M-type phospholipase A2 receptor (PLA2R) negative membranous nephropathy in European and North ...
Liu, Gang, Probst, Christian, Cui, Zhao, Pierre Ronco, Wang, Xin, Ronco, Pierre, Hanna Debiec, Fang Wang, Zhao Cui, Xin Wang, Ming-hui Zhao, Lu, Jie, Qu, Zhen, Jia Wang, Debiec, Hanna, Jie Lu, Li-qiang Meng, Zhen Qu, Christian Probst, Yi-miao Zhang, Wang, Jia, Wang, Fang, Gang Liu, Xu-yang Cheng, Cheng, Xu-Yang, Zhao, Ming-Hui, Meng, Li-Qiang, Zhang, Yi-Miao   +27 more
core   +1 more source

ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1) [PDF]

, 2009
Review on ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1), with data on DNA, on the protein encoded, and where the gene is ...
Rocks, N, Cataldo, D
core   +1 more source

Revisiting immunological and clinical aspects of membranous nephropathy.

, 2022
20.500.12530/87854Idiopathic or primary membranous nephropathy (IMN) is one of the most frequent causes of nephrotic syndrome in adults and the elderly. It is characterized by a thickening of the wall of the glomerular capillaries due to the presence of ...
Iturrieta-Zuazo, Ignacio, Nieto-Gañán, Israel, Rita, Claudia, Carrasco-Sayalero, Ángela   +3 more
core   +1 more source