Results 41 to 50 of about 198,310 (292)

Campylobacter jejuni enters gut epithelial cells and impairs intestinal barrier function through cleavage of occludin by serine protease HtrA

Gut Pathogens, 2019
Campylobacter jejuni secretes HtrA (high temperature requirement protein A), a serine protease that is involved in virulence. Here, we investigated the interaction of HtrA with the host protein occludin, a tight junction strand component ...
Aileen Harrer, Roland Bücker, Manja Boehm, Urszula Zarzecka, Nicole Tegtmeyer, Heinrich Sticht, Jörg D. Schulzke, Steffen Backert   +7 more
doaj   +1 more source

YAP1 recruits c-Abl to protect angiomotin-like 1 from Nedd4-mediated degradation. [PDF]

PLoS ONE, 2012
Tissue development and organ growth require constant remodeling of cell-cell contacts formed between epithelial cells. The Hippo signaling cascade curtails organ growth by excluding the transcriptional co-activator Yes Associated Protein 1 (YAP1) from ...
Kassiani Skouloudaki, Gerd Walz
doaj   +1 more source

Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells [PDF]

, 2015
Capsaicin has known pharmacological effects including the ability to reversibly open cellular tight junctions, among others. The aim of this study was to develop a strategy to enhance the paracellular transport of a substance with low permeability (FITC ...
A- Choi, AF Kotzé, AY Choi, B Menchicchi, C Prego, C Prego, C Prego, C Turgut, CA Schneider, D Carl, D Vllasaliu, F Denizot, F Xing, FM Goycoolea, H Zhang, J- Yeh, JC Lapez-Montilla, JD Irvine, K Roy, K Sonaje, K Sonaje, LM Lucht, M Gekle, M Nampally, M Rinaudo, MJ Caterina, MK Meghvansi, MV Lozano, NGM Schipper, NGM Schipper, P Artursson, P Artursson, PL Ritger, R Lee, S Charlton, S Paris, S Tsukita, S Vicente, SK Nitta, T Nagamoto, T Yeh, V Dodane, Y Tsukura   +42 more
core   +1 more source

The role of endothelial junctions in the regulation of the extravasation of tumor cells. A historical reappraisal

Frontiers in Oncology
Endothelial cells lining the vessel wall are connected by adherent, tight and gap junctions. Adherent junctions are common to all endothelial cells, whereas tight and gap junctions graduate within different vascular segments.
Domenico Ribatti
doaj   +1 more source

The microscopic basis for phase-sensitive experiments for determination of the order parameter symmetry in Fe-based superconductors

, 2013
We present a microscopic theory of dc Josephson current, based on the construction of a coherent temperature Green function in the tight-binding approximation, in junctions with multiband superconductors.
Burmistrova, A. V., Devyatov, I. A.
core   +1 more source

Effect of cAMP derivates on assembly and maintenance of tight junctions in human umbilical vein endothelial cells

BMC Cell Biology, 2010
Background Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on
Beese Michaela, Wyss Kristin, Haubitz Marion, Kirsch Torsten   +3 more
doaj   +1 more source

A novel in vitro platform for the study of SN38-induced mucosal damage and the development of Toll-like receptor 4-targeted therapeutic options [PDF]

, 2016
Tight junction and epithelial barrier disruption is a common trait of many gastrointestinal pathologies, including chemotherapy-induced gut toxicity. Currently, there are no validated in vitro models suitable for the study of chemotherapy-induced mucosal
Bowen, J., Gibson, R., Logan, R., Secombe, K., Van Sebille, Y., Wardill, H.   +5 more
core   +1 more source

Survival for Children Diagnosed With Wilms Tumour (2012–2022) Registered in the UK and Ireland Improving Population Outcomes for Renal Tumours of Childhood (IMPORT) Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga, Angela Lopez‐Cortes, Reem Al‐Saadi, Suzanne Tugnait, Kristina Dzhuma, Catriona Duncan, Gordan Vujanic, Tanzina Chowdhury, Claudia Allemani, Michel P. Coleman, Kathy Pritchard‐Jones, the Children's Cancer and Leukaemia Group (CCLG) Renal Tumour Special Interest Group, Hugh Bishop, Anthony McCarthy, Pamela Kearns, Helen Rees, Amos Burke, Meriel Jenney, Jane Pears, Hamish Wallace, Milind Ronghe, Tanzina Chowdhury, Susan Picton, Emma Ross, Lisa Howell, Bernadette Brennan, Gail Halliday, Richard Grundy, Shaun Wilson, Sucheta Vaidya, Daniel Yeomanson, Jessica Bate, Vesna Pavasovic, Jessica Bate, Sabine Irtan, Jesper Brok, Minou Oostveen, Kristina Dzhuma, Mark Weeks, Richard Williams, Mark Powis, Max Pachl, Bruce Okoye, Naima Smeulders, Gordan Vujanic, Oystein Olsen, Tom Watson, Susan Shelmerdine, Dan Saunders, Angela Lopez-Cortes, Taryn Treger, Tom Jackson, Suzanne Tugnait, Lisa Howell, Tanzina Chowdhury, Sam Behjati, Angela Polanco   +56 more
wiley   +1 more source

Atypical septate junctions maintain the somatic enclosure around maturing spermatids and prevent premature sperm release in Drosophila testis

Biology Open, 2019
Tight junctions prevent paracellular flow and maintain cell polarity in an epithelium. These junctions are also required for maintaining the blood-testis barrier, which is essential for sperm differentiation.
Pankaj Dubey, Tushna Kapoor, Samir Gupta, Seema Shirolikar, Krishanu Ray   +4 more
doaj   +1 more source

Negative differential resistance in nanotube devices

, 2000
Carbon nanotube junctions are predicted to exhibit negative differential resistance, with very high peak-to-valley current ratios even at room temperature.
A. A. Farajian, A. A. Odintsov, A. S. Maksimenko, C. Dekker, D. K. Roy, F. Léonard, F. Léonard, François Léonard, J. Chen, J. Li, J. Tersoff, J. W. G. Wildöer, J.-Y. Yi, K. Esfarjani, M. F. Lin, S. Datta, S. M. Sze, T. W. Odom, Y. Miyamoto   +18 more
core   +1 more source