Results 61 to 70 of about 196,709 (295)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Tight-binding study of bilayer graphene Josephson junctions

, 2012
Using highly efficient simulations of the tight-binding Bogoliubov-de Gennes model we solved self-consistently for the pair correlation and the Josephson current in a Superconducting-Bilayer graphene-Superconducting Josephson junction.
Covaci, L., Muñoz, W. A., Peeters, F. M.   +2 more
core   +1 more source

SnapShot: Epithelial Tight Junctions

Cell, 2014
Tight junctions form a morphological and functional border between the apical and basolateral cell surface domains that serves as a paracellular diffusion barrier, enabling epithelial cells to separate compartments of different composition. Tight junctions also contribute to the generation and maintenance of cell polarity and regulate signaling ...
Matter, Karl, Balda, Maria S.
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Rol de las uniones estrechas del epitelio intestinal en la patogenia de la enfermedad de Crohn

Anales de la Facultad de Medicina, 2015
Crohn’s disease is an inflammatory bowel disease that affects the intestinal wall. This wall consists of an epithelial cell layer that forms a continuous polarized monolayer, closely connected by various types of cellular junctions.
Dionisio Díaz, Rodrigo Dorelo, Diego Fleitas, Silvia Chifflet   +3 more
doaj  

Glial Cells in the Fish Retinal Nerve Fiber Layer Form Tight Junctions, Separating and Surrounding Axons

Frontiers in Molecular Neuroscience, 2018
In the retina of teleost fish, cell addition continues throughout life involving proliferation and axonal growth. To study how this is achieved in a fully functioning retina, we investigated the nerve fiber layer (NFL) of the cichlid fish Astatotilapia ...
Lidia Garcia-Pradas, Corinna Gleiser, Andrea Wizenmann, Hartwig Wolburg, Andreas F. Mack   +4 more
doaj   +1 more source

The effect of nearest neighbor spin-singlet correlations in conventional graphene SNS Josephson junctions

, 2009
Using the self-consistent tight-binding Bogoliubov-de Gennes formalism we have studied the effect of nearest neighbor spin-singlet bond (SB) correlations on Josephson coupling and proximity effect in graphene SNS Josephson junctions with conventional s ...
Annica M. Black-Schaffer, L. Pauling, Sebastian Doniach, Y. Kopelevich   +3 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

Cell Reports, 2017
Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly ...
Sarah E. Lutz, Julian R. Smith, Dae Hwan Kim, Carl V.L. Olson, Kyle Ellefsen, Jennifer M. Bates, Sunil P. Gandhi, Dritan Agalliu   +7 more
doaj   +1 more source