Results 91 to 100 of about 101,572 (275)
Advanced Intelligent Systems, EarlyView.R‐APEX is a knowledge graph platform developed to investigate how air pollutants such as particularly fine particulate matter (PM2.5) affect human health. By integrating large‐scale biomedical data and using machine learning, it reveals pollutant–gene–disease associations.
Zhixing Zhu +7 more
wiley +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Allergic rhinitis (AR) and asthma are involved in complex interactions between Th1 and Th2 inflammatory pathways. House dust mite (HDM) activates protease‐activated receptor 2 (PAR2) to trigger inflammatory responses, but current treatments often provide inadequate control.
Miran Kang +8 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez +3 more
wiley +1 more source
Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019 Receptorii Toll-like recunosc structurile moleculare legate de agentul patogen a micobacterii și, astfel, joacă un rol important în protecţia organismului faţă de infecţia tuberculoasă.
Alexandru Varzari +5 more
doaj
Advanced Biomedical ResearchBackground: Myelodysplastic syndrome (MDS) is a clonal hematologic disorder that requires the integration of morphologic, cytogenetic, hematologic, and clinical findings for a successful diagnosis.
Parvin Khalilian +4 more
doaj +1 more source
Systemic TLR2 tolerance enhances central nervous system remyelination
Journal of Neuroinflammation, 2019 Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko +9 more
doaj +1 more source
Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway
PLOS Pathogens, 2015 Human Cytomegalovirus (HCMV) encodes multiple microRNAs (miRNAs) whose functions are just beginning to be uncovered. Using in silico approaches, we identified the Toll-Like Receptor (TLR) innate immunity pathway as a possible target of HCMV miRNAs. Luciferase reporter assay screens further identified TLR2 as a target of HCMV miR-UL112-3p.
Daniel N. Streblow +5 more
openaire +5 more sources
Active Components of Leptospira Outer Membrane Protein LipL32 to Toll-Like Receptor 2
Scientific Reports, 2017 Proteins belonging to the toll-like receptor (TLR) family, particularly TLR2, are the major components of innate immunity against Leptospira infection.
Shen-Hsing Hsu +10 more
doaj +1 more source
Animal Research and One Health, EarlyView.Multi‐omics analysis revealed that FOS supplementation increased the abundance of Phascolarctobacterium, GCA‐900066575, Shuttleworthia, Olsenella, Eubacterium_hallii_group while decreasing Alistipes. It also influenced the metabolism of S‐lactoylglutathione, p‐cresol glucuronate, 2‐phenylethanol glucuronide, propionic acid, dulcitol, and inhibited the ...
Dan Song +11 more
wiley +1 more source
TLR2 signaling is required for the innate, but not adaptive response to LVS clpB
Frontiers in Immunology, 2014 Toll-like receptor 2 (TLR2) is the best characterized pattern-recognition receptor for the highly pathogenic intracellular bacterium, Francisella tularensis.
Lydia Marie Roberts +3 more
doaj +1 more source