Results 91 to 100 of about 151,127 (263)

Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity. [PDF]

PLoS ONE, 2014
TLR2 plays a critical role in the protection against Paracoccidioides brasiliensis conferred by ArtinM administration. ArtinM, a D-mannose-binding lectin from Artocarpus heterophyllus, induces IL-12 production in macrophages and dendritic cells, which ...
Vania Sammartino Mariano, Andre Luiz Zorzetto-Fernandes, Thiago Aparecido da Silva, Luciana Pereira Ruas, Lilian L Nohara, Igor Correia de Almeida, Maria Cristina Roque-Barreira   +6 more
doaj   +1 more source

RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis [PDF]

, 2017
Cryptococcus neoformans , the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells.
Doering, Tamara L, Hole, Camaron R, Khader, Shabaana A, Srikanta, Deepa, Williams, Matthew   +4 more
core   +2 more sources

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Epigenetic regulation of TLR2‐mediated periapical inflammation

International Endodontic Journal, 2020
AbstractAimTo determine the methylation pattern of TLR2 gene promoter and its association with the transcriptional regulation of periapical inflammatory and angiogenic responses in symptomatic and asymptomatic forms of apical periodontitis.MethodologyIn this cross‐sectional study, apical lesions were obtained from volunteers with asymptomatic apical ...
A. Fernández, P. Veloso, J. Astorga, C. Rodríguez, V.A. Torres, M. Valdés, M. Garrido, P.J. Gebicke‐Haerter, M. Hernández   +8 more
openaire   +3 more sources

TLR2-mediated neutrophil depletion exacerbates bacterial sepsis [PDF]

Proceedings of the National Academy of Sciences, 2009
The host antimicrobial defense response is initiated by the innate immune system, the most ancient of the 2 limbs of the immune system. The innate immune system is activated as soon as a pathogen crosses the host external defense barriers, lasts for a few hours, and is aimed at the elimination of the invading microorganism.
Thierry, Roger, Thierry, Calandra
openaire   +2 more sources

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Intestinal epithelial responses to Salmonella enterica serovar Enteritidis: Effects on intestinal permeability and ion transport [PDF]

, 2019
Salmonella infection of chickens that leads to potential human foodborne salmonellosis continues to be a major concern. Chickens serve as carriers but, in contrast to humans, rarely show any clinical signs including diarrhea.
Aschenbach, J. R., Awad, W. A., Hess, C., Hess, M., Khayal, B.   +4 more
core   +1 more source

POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation

Advanced Science, EarlyView.
Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia, Jinguan Lin, Xianjie Jiang, Linda Oyang, Shiming Tan, Zongyao Ren, Qiu Peng, Qianjin Liao, Yujuan Zhou   +8 more
wiley   +1 more source

Crosstalk between NOD2 and TLR2 suppresses the development of TLR2-mediated experimental colitis

Journal of Clinical Biochemistry and Nutrition
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for muramyl dipeptide (MDP), a degradation product of bacterial cell wall peptidoglycan (PGN). PGN stimulates cell-surface Toll-like receptor 2 (TLR2) independently of NOD2, indicating the presence of crosstalk between extracellular TLR2 and intracellular NOD2 upon exposure ...
Okai, Natsuki, Masuta, Yasuhiro, Otsuka, Yasuo, Hara, Akane, Masaki, Sho, Kamata, Ken, Minaga, Kosuke, Honjo, Hajime, Kudo, Masatoshi, Watanabe, Tomohiro   +9 more
openaire   +2 more sources

CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN

Медицинская иммунология, 2019
At the present time, the role of innate immunity in pathogenesis of bronchial asthma (BA) is actively studied, in particular, significance of TLRs and cytokines. The study included 42 patients with severe bronchial asthma (from 3 to 12 years old), and 67
L. V. Gankovskaya, L. S. Namazova-Baranova, G. V. Poriadin, V. V. Grechenko, V. A. Gankovsky, A. A. Alekseeva, Zh. M. Salmashi, A. N. Kazimirsky, B. G. Bragvadze, O. A. Svitich   +9 more
doaj   +1 more source