Results 101 to 110 of about 133,056 (344)
Scientific Reports, 2017 Nevertheless its mechanism has not been well explained yet, PM2.5 is recognized to exacerbate asthma. In the present study, the roles of toll-like receptor (TLR) 2, TLR4 and MyD88, in exacerbation of allergen-induced lung eosinophilia caused by urban PM2.
M. He +7 more
semanticscholar +1 more source
Advances and Strategies in Enhancing mRNA Cancer Vaccines
Advanced Materials, EarlyView.Messenger RNA (mRNA) vaccines offer a powerful approach for cancer immunotherapy, but their clinical impact remains limited by delivery challenges and suboptimal immune activation. This review discusses key biological barriers and design strategies—including structural optimization, immunomodulation, organ targeting delivery, and advanced nanocarriers ...
Miao Zhang +4 more
wiley +1 more source
Role of TLR2 in lung angiogenesis
The FASEB Journal, 2009 After chronic left pulmonary artery ligation (LPAL) in mice, there is rapid neovascularization of the ischemic lung. We showed increased macrophage‐derived growth factors and a positive correlation between the number of lavaged macrophages and the magnitude of angiogenesis.
Aigul Moldobaeva +3 more
openaire +1 more source
Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. [PDF]
PLoS ONE, 2008 Accumulating evidence implicates a fundamental link between the immune system and atherosclerosis. Toll-like receptors are principal sensors of the innate immune system.
Monika Madan, Salomon Amar
doaj +1 more source
Frontiers in Immunology, 2023 Host immune activation is critical for enterovirus 71 (EV71) clearance and immunopathogenesis. However, the mechanism of innate immune activation, especially of cell membrane-bound toll-like receptors (TLRs), against EV71 remains unknown.
Ping-Ping Sun +8 more
doaj +1 more source
European Heart Journal, 2015 AIMS Superficial erosion of atheromata causes many acute coronary syndromes, but arises from unknown mechanisms. This study tested the hypothesis that Toll-like receptor-2 (TLR2) activation contributes to endothelial apoptosis and denudation and thus ...
T. Quillard +5 more
semanticscholar +1 more source
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
TLR2-Mediated Cell Stimulation in Bacterial Vaginosis [PDF]
Journal of Lower Genital Tract Disease, 2008 Bacterial vaginosis (BV) is associated with preterm labor, pelvic inflammatory disease (PID) and increased HIV acquisition, although the pathways that mediate these pathological effects have not been elucidated. To determine the presence of Toll-like receptor (TLR)-ligands and their specificity in BV, genital tract fluids were collected from women with
José Antonio Simões +3 more
openaire +4 more sources
Научно-практическая ревматологияThe aim of the study was to reveal the relationship between the activity of inflammation, the infectious component, platelet function and dyslipidemia, in the development of subclinical atherosclerosis in patients with systemic lupus erythematosus (SLE ...
A. V. Arshinov +4 more
doaj +1 more source
TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut
Journal of Immunology, 2019 Key Points TLR2 plays a key role in gut serotonin production by both resident microbiota and a parasite. TLR2 in nonhematopoietic cells is largely responsible for serotonin production in the gut.
Huaqing Wang +8 more
semanticscholar +1 more source