Results 101 to 110 of about 101,572 (275)
Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis [PDF]
, 2000 Robin R. Ingalls +2 more
openalex +1 more source
Targeting microglial TLR2 in glioma therapy
, 2021 Gliomas are the most frequent brain tumors and are characterized by a poor prognosis despite extensive research in recent years. Microglia constitute the main population of immune cells in the central nervous system and ensure the compliance of homeostasis under physiologic conditions but they have been found to play a pivotal role in tumor progression.
openaire +2 more sources
TLR2 Controls Intestinal Carcinogen Detoxication by CYP1A1
PLoS ONE, 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). The expression of CYP1 (including CYP1A2 and CYP1B1) is considered to depend solely on a heterodimeric transcription factor consisting of the arylhydrocarbon receptor (AHR ...
Alexandr Parlesak +5 more
openaire +7 more sources
Antiphospholipid Syndrome: An Antibody‐Mediated Disease With Emerging Therapeutic Opportunities
Arthritis &Rheumatology, EarlyView.Antiphospholipid syndrome (APS) is an autoimmune thromboinflammatory disease characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS ...
Thalia G. Newman, Jason S. Knight
wiley +1 more source
Infection and Drug Resistance, 2019 Zhiyong Wu,1,* Chunli Chen,1,* Yusong Miao,1 Yuhao Liu,1 Qiaomei Zhang,1 Rui Li,1 Liangjun Ding,1 Muhammad Ishfaq,1 Jichang Li1,2 1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People’s Republic of China ...
Wu Z +8 more
doaj
PLoS ONE, 2019 Subacute and chronic infections with the intracellular protozoan parasite Toxoplasma gondii are associated with an increased risk of psychiatric diseases like schizophrenia. However, little is known about the mechanisms involved in T.
Fumiaki Ihara +4 more
doaj +1 more source
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, EarlyView.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells [PDF]
, 2001 R. Martin Vabulas +6 more
openalex +1 more source
Oxidative Stress Modulation and Antileishmanial Activity of Salvinia auriculata
Chemistry &Biodiversity, EarlyView.Ethanolic extract of Salvinia auriculata showed significant antioxidant and antileishmanial activities. Salviniside II, the major metabolite, was isolated, structurally characterized, and evaluated, but exhibited weaker antiparasitic effects when compared to the whole extract.
Augusto César Rodrigues +6 more
wiley +1 more source
Ontogeny of Toll-Like Receptors Tlr2 and Tlr4 in Mice [PDF]
, 2001 Kirsi Harju +2 more
openalex +1 more source