Results 11 to 20 of about 151,127 (263)

Targeting TLR2 for Vaccine Development [PDF]

Journal of Immunology Research, 2014
Novel and more effective immunization strategies against many animal diseases may profit from the current knowledge on the modulation of specific immunity through stimulation of innate immune receptors. Toll-like receptor (TLR)2-targeting formulations, such as synthetic lipopeptides and antigens expressed in fusion with lipoproteins, have been shown to
Afonso P. Basto, Alexandre Leitão
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TLR2 Looks at Lipoproteins [PDF]

Immunity, 2009
Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.
Schenk, Mirjam, Belisle, John T., Modlin, Robert L.   +2 more
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Sialylation of TLR2 initiates osteoclast fusion [PDF]

Bone Research, 2022
AbstractThe molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2 binding is indispensable and occurs prior to cell fusion in RANKL-mediated osteoclastogenesis. Siglec15 has been shown to regulate osteoclastic bone resorption.
Ce Dou, Gehua Zhen, Yang Dan, Mei Wan, Nathachit Limjunyawong, Xu Cao   +5 more
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Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation [PDF]

BMC Biotechnology, 2010
AbstractBackgroundToll-like receptor (TLR) 2 is a component of the innate immune system and senses specific pathogen associated molecular patterns (PAMPs) of both microbial and viral origin. Cell activation via TLR2 and other pattern recognition receptors (PRRs) contributes to sepsis pathology and chronic inflammation both relying on overamplification ...
Kirschning, Carsten Jürgen, Dreher, Stefan, Maaß, Björn, Fichte, Sylvia, Schade, Jutta, Köster, Mario, Noack, Andreas, Lindenmaier, Werner, Wagner, Hermann, Böldicke, Thomas   +9 more
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TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors [PDF]

Journal of Leukocyte Biology, 2013
ABSTRACTTLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation.
Bergenhenegouwen, J. van, Plantinga, T.S., Joosten, L.A.B., Netea, M.G., Folkerts, G., Kraneveld, A.D., Garssen, J., Vos, A.P.   +7 more
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Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation [PDF]

Nutrients, 2018
Toll-like receptor 2 (TLR2) responses are involved in various inflammatory immune disorders. Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit. Here, we investigated whether the anti-inflammatory activity of phloretin is mediated through TLR2 pathways, and whether phloretin acts as an inhibitor of TLR2/1 heterodimerization ...
Jieun Kim, Prasannavenkatesh Durai, Dasom Jeon, In Duk Jung, Seung Jun Lee, Yeong-Min Park, Yangmee Kim   +6 more
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Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering [PDF]

The Journal of Immunology, 2009
Abstract TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to control disease outcomes. We show in this study the ability of the soluble form of TLR2 (sTLR2) to regulate proinflammatory responses, and demonstrate the mechanisms ...
Anne-Catherine, Raby, Emmanuel, Le Bouder, Chantal, Colmont, James, Davies, Peter, Richards, Barbara, Coles, Christopher H, George, Simon A, Jones, Paul, Brennan, Nicholas, Topley, Mario O, Labéta   +10 more
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TLR2 Mediates Neuroinflammation and Neuronal Damage [PDF]

The Journal of Immunology, 2007
Abstract Innate immunity relies on pattern recognition receptors to detect the presence of infectious pathogens. In the case of Gram-positive bacteria, binding of bacterial lipopeptides to TLR2 is currently regarded as an important mechanism.
Hoffmann, O., Braun, J., Becker, D., Halle, A., Freyer, D., Dagand, E., Lehnardt, S., Weber, J.   +7 more
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Anti-tumor necrosis factor-alpha therapy during murine Klebsiella pneumoniae bacteremia: increased mortality in the absence of liver injury. [PDF]

, 2003
Klebsiella pneumoniae is a leading cause of gram-negative bacterial pneumonia, often resulting in bacteremia concurrent with the localized pulmonary infection.
Cogen, Anna L, Lau, Helen Y, Monteleon, Christine L, Moore, Thomas A, Standiford, Theodore J   +4 more
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The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response [PDF]

, 2016
Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response.
Banerjee, Batard, Bergenhenegouwen, Bublin, Calderón, Chan, Chiou, Eriksson, Eriksson, Gillilan, Gras, Guillot, Herre, Hunter, Jacquet, Jacquet, Jacquet, Jenkins, Jeong, Jimenez, Kennedy, Kennedy, Kidon, Kitajima, Lambrecht, Li, Liang, Liu, Mei, Mueller, Mueller, Osterlund, Puerta, Pulsawat, Ryu, Soh, Storch, Taylor, Thomas, Tovey, Trompette, Tully, Wiegand, Young, Zähringer   +44 more
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