Results 11 to 20 of about 101,572 (275)
TLR2 Looks at Lipoproteins [PDF]
Immunity, 2009 Toll-like receptors (TLRs) have evolved to recognize lipoproteins from diverse species of bacteria. In this issue of Immunity, Kang et al. (2009) provide insight into the mechanisms by which TLR2-TLR6 heterodimers recognize diacylated liporoteins, whereas TLR2-TLR1 heterodimers recognize triacylated lipopeptides.
Robert L. Modlin +3 more
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TLR2 is expressed on activated T cells as a costimulatory receptor [PDF]
Proceedings of the National Academy of Sciences, 2004 Toll is the founder of a group of pattern recognition receptors that play a critical role in the innate immunity in Drosophila . At least 10 distinct Toll-like receptors (TLRs), recognizing pathogen-associated molecular patterns, have now been identified in humans.
Mousa Komai‐Koma +4 more
openalex +6 more sources
TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors [PDF]
Journal of Leukocyte Biology, 2013 ABSTRACTTLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation.
Bergenhenegouwen, J. van +7 more
openaire +5 more sources
Targeting TLR2 for Vaccine Development [PDF]
Journal of Immunology Research, 2014 Novel and more effective immunization strategies against many animal diseases may profit from the current knowledge on the modulation of specific immunity through stimulation of innate immune receptors. Toll-like receptor (TLR)2-targeting formulations, such as synthetic lipopeptides and antigens expressed in fusion with lipoproteins, have been shown to
Alexandre Leitão, Afonso P. Basto
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Sialylation of TLR2 initiates osteoclast fusion [PDF]
Bone Research, 2022 AbstractThe molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2 binding is indispensable and occurs prior to cell fusion in RANKL-mediated osteoclastogenesis. Siglec15 has been shown to regulate osteoclastic bone resorption.
Ce Dou +5 more
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Generation of anti-TLR2 intrabody mediating inhibition of macrophage surface TLR2 expression and TLR2-driven cell activation [PDF]
BMC Biotechnology, 2010 AbstractBackgroundToll-like receptor (TLR) 2 is a component of the innate immune system and senses specific pathogen associated molecular patterns (PAMPs) of both microbial and viral origin. Cell activation via TLR2 and other pattern recognition receptors (PRRs) contributes to sepsis pathology and chronic inflammation both relying on overamplification ...
Kirschning, Carsten Jürgen +9 more
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The Role of TLR2 in Infection and Immunity [PDF]
Frontiers in Immunology, 2012 Toll-like receptors (TLRs) are recognition molecules for multiple pathogens, including bacteria, viruses, fungi, and parasites. TLR2 forms heterodimers with TLR1 and TLR6, which is the initial step in a cascade of events leading to significant innate immune responses, development of adaptive immunity to pathogens and protection from immune sequelae ...
Paola Massari +2 more
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Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation [PDF]
Nutrients, 2018 Toll-like receptor 2 (TLR2) responses are involved in various inflammatory immune disorders. Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit. Here, we investigated whether the anti-inflammatory activity of phloretin is mediated through TLR2 pathways, and whether phloretin acts as an inhibitor of TLR2/1 heterodimerization ...
Jieun Kim +6 more
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TLR2 and TLR4 in Ischemia Reperfusion Injury [PDF]
Mediators of Inflammation, 2010 Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood supply returns to tissue after a period of ischemia and is associated with trauma, stroke, myocardial infarction, and solid organ transplantation. Although the cause of this injury is multifactorial, increasing experimental evidence suggests an important role for the ...
A. E. Parker +3 more
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Identification of a TLR2 Inhibiting Wheat Hydrolysate [PDF]
Molecular Nutrition & Food Research, 2018 ScopeWheat hydrolysates are used in medical nutrition to provide undernourished patients a readily digestible protein source, for instance to recover from chemotherapy‐induced intestinal mucosal inflammation. Since many hydrolysates of different sources can modulate the immune system, likely via Toll‐like receptors (TLRs), it is hypothesized that also ...
Laurien H. Ulfman +6 more
openaire +4 more sources