Results 21 to 30 of about 156,491 (330)

Anti-tumor necrosis factor-alpha therapy during murine Klebsiella pneumoniae bacteremia: increased mortality in the absence of liver injury. [PDF]

, 2003
Klebsiella pneumoniae is a leading cause of gram-negative bacterial pneumonia, often resulting in bacteremia concurrent with the localized pulmonary infection.
Cogen, Anna L, Lau, Helen Y, Monteleon, Christine L, Moore, Thomas A, Standiford, Theodore J   +4 more
core   +1 more source

Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia

Вавиловский журнал генетики и селекции, 2021
The innate Iнн\mmune system is the first to respond to invading pathogens. It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity.
S. V. Mikhailova, L. V. Shcherbakova, N. I. Logvinenko, I. I. Logvinenko, M. I. Voevoda   +4 more
doaj   +1 more source

Bacterial membrane vesicles and phages in blood after consumption of Lacticaseibacillus rhamnosus JB-1

Gut Microbes, 2021
Gut microbiota have myriad roles in host physiology, development, and immunity. Though confined to the intestinal lumen by the epithelia, microbes influence distal systems via poorly characterized mechanisms.
Kevin Champagne-Jorgensen, Tamina A. Jose, Andrew M. Stanisz, M. Firoz Mian, Alexander P. Hynes, John Bienenstock   +5 more
doaj   +1 more source

Enhanced TLR2 responses in multiple sclerosis [PDF]

Clinical and Experimental Immunology, 2018
Summary The roles of the microbiome and innate immunity in the pathogenesis of multiple sclerosis (MS) remain unclear. We have previously documented abnormally low levels of a microbiome-derived Toll-like receptor (TLR)2-stimulating bacterial lipid in the blood of MS patients and postulated that this is indicative of a deficiency in the ...
M Fujiwara, E J Anstadt, B Flynn, K Morse, C Ng, P Paczkowski, J Zhou, S Mackay, N Wasko, F Nichols, R B Clark   +10 more
openaire   +2 more sources

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. [PDF]

, 2016
Toll-like receptors (TLRs) play an important role in the innate and adaptive immune responses to pathogens, and are the target of new vaccine adjuvants.
Bates, PA, Guimarães, A, Halliday, A, Taylor, MJ, Turner, JD   +4 more
core   +7 more sources

TLR2 Mediates Immunity to Experimental Cysticercosis [PDF]

International Journal of Biological Sciences, 2011
Information concerning TLR-mediated antigen recognition and regulation of immune responses during helminth infections is scarce. TLR2 is a key molecule required for innate immunity and is involved in the recognition of a wide range of viruses, bacteria, fungi and parasites. Here, we evaluated the role of TLR2 in a Taenia crassiceps cysticercosis model.
José L, Reyes, Marisol I, González, Yadira, Ledesma-Soto, Abhay R, Satoskar, Luis I, Terrazas   +4 more
openaire   +2 more sources

IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893 [PDF]

, 2018
Immunoglobulin (Ig) A in the mucus of the intestinal tract plays an important role in preventing the invasion of pathogenic microorganisms and regulating the composition of the gut microbiota.
Katakura Yoshio, Kunisawa Jun, Miyoshi Yuki, Nakayama Tomoya, Yamasaki-yashiki Shino, 中山 友哉, 山崎（屋敷） 思乃, 片倉 啓雄   +7 more
core   +2 more sources

Human mast cells promote colon cancer growth via bidirectional crosstalk: studies in 2D and 3D coculture models

OncoImmunology, 2018
Chronic inflammation drives the development of colorectal cancer (CRC), where tumor-infiltrating immune cells interact with cancer cells in a dynamic crosstalk.
Yingxin Yu, Bart Blokhuis, Yvonne Derks, Sangeeta Kumari, Johan Garssen, Frank Redegeld   +5 more
doaj   +1 more source

Differential induction of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by Trichophyton rubrum and Microsporum gypseum

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU, Weiwei DENG, Shuting ZHAN, Panpan LIANG, Meirong LI, Songchao YIN, Jian CHEN   +6 more
doaj   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Boehm, Olaf, Bornstein, Stefan R., Grotemeyer, Dirk, Hamann, Lutz, Koch, Alexander, Kurt, Muhammed, Schott, Matthias, Schumann, Ralf R., Schwenke, Carsten, Zacharowski, Kai   +9 more
core   +2 more sources