Results 21 to 30 of about 151,127 (263)
Вавиловский журнал генетики и селекции, 2021 The innate Iнн\mmune system is the first to respond to invading pathogens. It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity.
S. V. Mikhailova +4 more
doaj +1 more source
Enhanced TLR2 responses in multiple sclerosis [PDF]
Clinical and Experimental Immunology, 2018 Summary The roles of the microbiome and innate immunity in the pathogenesis of multiple sclerosis (MS) remain unclear. We have previously documented abnormally low levels of a microbiome-derived Toll-like receptor (TLR)2-stimulating bacterial lipid in the blood of MS patients and postulated that this is indicative of a deficiency in the ...
M Fujiwara +10 more
openaire +2 more sources
Gut Microbes, 2021 Gut microbiota have myriad roles in host physiology, development, and immunity. Though confined to the intestinal lumen by the epithelia, microbes influence distal systems via poorly characterized mechanisms.
Kevin Champagne-Jorgensen +5 more
doaj +1 more source
TLR2 Mediates Immunity to Experimental Cysticercosis [PDF]
International Journal of Biological Sciences, 2011 Information concerning TLR-mediated antigen recognition and regulation of immune responses during helminth infections is scarce. TLR2 is a key molecule required for innate immunity and is involved in the recognition of a wide range of viruses, bacteria, fungi and parasites. Here, we evaluated the role of TLR2 in a Taenia crassiceps cysticercosis model.
José L, Reyes +4 more
openaire +2 more sources
OncoImmunology, 2018 Chronic inflammation drives the development of colorectal cancer (CRC), where tumor-infiltrating immune cells interact with cancer cells in a dynamic crosstalk.
Yingxin Yu +5 more
doaj +1 more source
Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation [PDF]
, 2014 Funding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported
Biedermann, Tilo +12 more
core +4 more sources
Pifu-xingbing zhenliaoxue zazhi, 2021 Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU +6 more
doaj +1 more source
A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis [PDF]
, 2019 Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin ...
Barbierato, M. +5 more
core +1 more source
EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA
Медицинская иммунология, 2017 Currently actively discussed the role of innate immunity receptors, in particular TLRs in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya +7 more
doaj +1 more source
IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893 [PDF]
, 2018 Immunoglobulin (Ig) A in the mucus of the intestinal tract plays an important role in preventing the invasion of pathogenic microorganisms and regulating the composition of the gut microbiota.
Katakura Yoshio +7 more
core +2 more sources