Results 21 to 30 of about 101,572 (275)

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering [PDF]

The Journal of Immunology, 2009
Abstract TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to control disease outcomes. We show in this study the ability of the soluble form of TLR2 (sTLR2) to regulate proinflammatory responses, and demonstrate the mechanisms ...
Peter James Richards, Simon Arnett Jones, Emmanuel Jerome Le Bouder, Paul Brennan, Chantal Sophie Colmont, Christopher H. George, Mario O. Labéta, Anne-Catherine Raby, James A. Davies, Barbara Coles, Nicholas Topley   +10 more
openaire   +4 more sources

Structural and Functional Evidence for the Role of the TLR2 DD Loop in TLR1/TLR2 Heterodimerization and Signaling [PDF]

Journal of Biological Chemistry, 2006
The Toll/Interleukin-1 receptor (TIR) domain of the Toll-like receptors (TLRs) plays an important role in innate host defense signaling. The TIR-TIR platform formed by the dimerization of two TLRs promotes homotypic protein-protein interactions with additional cytoplasmic adapter molecules to form an active signaling complex resulting in the expression
Laurey Comeau, Jitendra K. Gautam, Ashish, Michael F. Smith, Joanna K. Krueger   +4 more
openaire   +3 more sources

Enhanced TLR2 responses in multiple sclerosis [PDF]

Clinical and Experimental Immunology, 2018
Summary The roles of the microbiome and innate immunity in the pathogenesis of multiple sclerosis (MS) remain unclear. We have previously documented abnormally low levels of a microbiome-derived Toll-like receptor (TLR)2-stimulating bacterial lipid in the blood of MS patients and postulated that this is indicative of a deficiency in the ...
M Fujiwara, E J Anstadt, B Flynn, K Morse, C Ng, P Paczkowski, J Zhou, S Mackay, N Wasko, F Nichols, R B Clark   +10 more
openaire   +3 more sources

GINGIVAL FIBROBLAST MICROVESICLES MODULATE PRO-B CELLS APOPTOSIS IN SPECIFIC EXPERIMENTAL CONDITIONS

Romanian Journal of Oral Rehabilitation, 2023
Aim of the study The fast development of the tumor mass in acute lymphoblastic leukemia is dependent not only on the rate of cell proliferation, but also on the rate of apoptosis, with NR4A1 governing both tumor cell survival and death.
Carmen (Amititeloaie) Gentimir, Gabriela Geleţu, Andreea (Tibeică) Iordan, Marcel Costuleanu   +3 more
doaj  

TLR2: A Crossroads between Infections and Autoimmunity? [PDF]

International Journal of Immunopathology and Pharmacology, 2011
Environment has both pathogenic and protective roles in the determination of autoimmune disease development, possibly through infectious agents. TLR2 has the capability to recognize the widest range of PAMPs, and it is important for the recognition of mycobacteria and gram-positive bacteria. Here we review recent information showing that TLR2 ligands,
Borrello, Silvia, Nicolò, C, Delogu, Giovanni, Pandolfi, Franco, Ria, Francesco   +4 more
openaire   +4 more sources

Human mast cells promote colon cancer growth via bidirectional crosstalk: studies in 2D and 3D coculture models

OncoImmunology, 2018
Chronic inflammation drives the development of colorectal cancer (CRC), where tumor-infiltrating immune cells interact with cancer cells in a dynamic crosstalk.
Yingxin Yu, Bart Blokhuis, Yvonne Derks, Sangeeta Kumari, Johan Garssen, Frank Redegeld   +5 more
doaj   +1 more source

Differential induction of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by Trichophyton rubrum and Microsporum gypseum

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU, Weiwei DENG, Shuting ZHAN, Panpan LIANG, Meirong LI, Songchao YIN, Jian CHEN   +6 more
doaj   +1 more source

Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene [PDF]

Human Molecular Genetics, 2007
In the innate immune system, TLR2 plays a central role for the response to a wide variety of microbial and endogenous danger signals. A considerable number of genetic polymorphisms within the human TLR2 gene have been reported in non-coding and coding sequences.
Michael Neumaier, Parviz Ahmad-Nejad, Carsten J. Kirschning, Sabine Merx, Hermann Wagner   +4 more
openaire   +3 more sources

Neonatal Cystitis Makes Adult Female Rat Urinary Bladders More Sensitive to Low Concentration Microbial Antigens

Research and Reports in Urology, 2023
Ashley C Archer,1 Jennifer J DeBerry,2 Cary DeWitte,2 Timothy J Ness2 1University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA; 2Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, Birmingham,
Archer AC, DeBerry JJ, DeWitte C, Ness TJ   +3 more
doaj  

The function of TLR2 during staphylococcal diseases [PDF]

Frontiers in Cellular and Infection Microbiology, 2013
Staphylococcus aureus is a versatile pathogen causing a wide range of infections. It has been a major threat both in hospitals and in the community for decades. S. aureus is a pyogenic bacterium that elicits recruitment of polymorphonuclear leukocytes (neutrophils) to the site of infection.
openaire   +4 more sources