Results 31 to 40 of about 133,056 (344)

Anti-tumor necrosis factor-alpha therapy during murine Klebsiella pneumoniae bacteremia: increased mortality in the absence of liver injury. [PDF]

, 2003
Klebsiella pneumoniae is a leading cause of gram-negative bacterial pneumonia, often resulting in bacteremia concurrent with the localized pulmonary infection.
Cogen, Anna L, Lau, Helen Y, Monteleon, Christine L, Moore, Thomas A, Standiford, Theodore J   +4 more
core   +1 more source

Anti-inflammatory protein TSG-6 secreted by bone marrow mesenchymal stem cells attenuates neuropathic pain by inhibiting the TLR2/MyD88/NF-κB signaling pathway in spinal microglia

Journal of Neuroinflammation, 2020
Neuroinflammation plays a vital role in the development and maintenance of neuropathic pain. Recent evidence has proved that bone marrow mesenchymal stem cells (BMSCs) can inhibit neuropathic pain and possess potent immunomodulatory and immunosuppressive
Hao Yang, Lingmin Wu, Huimin Deng, Yuanli Chen, Huanping Zhou, Meiyun Liu, Shaocheng Wang, Li Zheng, Lina Zhu, Xin Lv   +9 more
semanticscholar   +1 more source

Soluble TLR2 Reduces Inflammation without Compromising Bacterial Clearance by Disrupting TLR2 Triggering [PDF]

The Journal of Immunology, 2009
Abstract TLR overactivation may lead to end organ damage and serious acute and chronic inflammatory conditions. TLR responses must therefore be tightly regulated to control disease outcomes. We show in this study the ability of the soluble form of TLR2 (sTLR2) to regulate proinflammatory responses, and demonstrate the mechanisms ...
Peter James Richards, Simon Arnett Jones, Emmanuel Jerome Le Bouder, Paul Brennan, Chantal Sophie Colmont, Christopher H. George, Mario O. Labéta, Anne-Catherine Raby, James A. Davies, Barbara Coles, Nicholas Topley   +10 more
openaire   +4 more sources

Polymorphism of genes associated with infectious lung diseases in Northern Asian populations and in patients with community-acquired pneumonia

Вавиловский журнал генетики и селекции, 2021
The innate Iнн\mmune system is the first to respond to invading pathogens. It is responsible for invader recognition, immune-cell recruitment, adaptive-immunity activation, and regulation of inflammation intensity.
S. V. Mikhailova, L. V. Shcherbakova, N. I. Logvinenko, I. I. Logvinenko, M. I. Voevoda   +4 more
doaj   +1 more source

TLR2-Melatonin Feedback Loop Regulates the Activation of NLRP3 Inflammasome in Murine Allergic Airway Inflammation

Frontiers in Immunology, 2020
Toll-like receptor 2 (TLR2) is suggested to initiate the activation of NLRP3 inflammasome, and considered to be involved in asthma. The findings that melatonin modulates TLRs-mediated immune responses, together with the suppressing effect of TLRs on ...
Hui-Mei Wu, Cui-Cui Zhao, Qiu-Meng Xie, Juan Xu, G. Fei   +4 more
semanticscholar   +1 more source

Fungal Chitin Dampens Inflammation through IL-10 Induction Mediated by NOD2 and TLR9 Activation [PDF]

, 2014
Funding: JW and NARG thank the Wellcome Trust (080088, 086827, 075470), The Wellcome Trust Strategic Award in Medical Mycology and Fungal Immunology (097377) and the European Union ALLFUN (FP7/2007 2013, HEALTH-2010-260338) for funding. MGN was supported
Biedermann, Tilo, Brown, Alistair J P, Brown, Gordon D, Gow, Neil A R, Kanneganti, Thirumala-Devi, Köberle, Martin, Lenardon, Megan D, MacCallum, Donna M, Malireddi, R K Subbarao, Netea, Mihai G, Schaller, Martin, Vautier, Simon, Wagener, Jeanette   +12 more
core   +8 more sources

The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response [PDF]

, 2016
Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response.
Banerjee, Batard, Bergenhenegouwen, Bublin, Calderón, Chan, Chiou, Eriksson, Eriksson, Gillilan, Gras, Guillot, Herre, Hunter, Jacquet, Jacquet, Jacquet, Jenkins, Jeong, Jimenez, Kennedy, Kennedy, Kidon, Kitajima, Lambrecht, Li, Liang, Liu, Mei, Mueller, Mueller, Osterlund, Puerta, Pulsawat, Ryu, Soh, Storch, Taylor, Thomas, Tovey, Trompette, Tully, Wiegand, Young, Zähringer   +44 more
core   +1 more source

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

Nature Communications, 2020
Vascular permeability and plasma leakage are immune-pathologies of severe dengue virus (DENV) infection, but the mechanisms underlying the exacerbated inflammation during DENV pathogenesis are unclear. Here, we demonstrate that TLR2, together with its co-
J. A. Aguilar-Briseño, Vinit Upasani, Bram M. ter Ellen, Jill Moser, Mindaugas Paužuolis, Mariana Ruiz-Silva, Sothy Heng, D. Laurent, Rithy Choeung, P. Dussart, T. Cantaert, J. Smit, Izabela A. Rodenhuis-Zybert   +12 more
semanticscholar   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Boehm, Olaf, Bornstein, Stefan R., Grotemeyer, Dirk, Hamann, Lutz, Koch, Alexander, Kurt, Muhammed, Schott, Matthias, Schumann, Ralf R., Schwenke, Carsten, Zacharowski, Kai   +9 more
core   +2 more sources

Human mast cells promote colon cancer growth via bidirectional crosstalk: studies in 2D and 3D coculture models

OncoImmunology, 2018
Chronic inflammation drives the development of colorectal cancer (CRC), where tumor-infiltrating immune cells interact with cancer cells in a dynamic crosstalk.
Yingxin Yu, Bart Blokhuis, Yvonne Derks, Sangeeta Kumari, Johan Garssen, Frank Redegeld   +5 more
doaj   +1 more source