Results 41 to 50 of about 101,572 (275)

MiR-344b-1-3p targets TLR2 and negatively regulates TLR2 signaling pathway

International Journal of Chronic Obstructive Pulmonary Disease, 2017
COPD is an abnormal inflammatory response characterized by decreased expression of TLR2 in patients, which is suggested to induce invasive pulmonary aspergillosis (IPA). MicroRNAs (miRNAs) have been shown to play important roles in the pathogenesis of human respiratory system disorders.
Deming Zhang, Zhenhui Guo, Qitao Yan, Weifeng Yuan, Hong Xu, Wenjie Huang, Li Li, Yuting Wu   +7 more
openaire   +6 more sources

TLR2 Mediates Neuroinflammation and Neuronal Damage [PDF]

The Journal of Immunology, 2007
Abstract Innate immunity relies on pattern recognition receptors to detect the presence of infectious pathogens. In the case of Gram-positive bacteria, binding of bacterial lipopeptides to TLR2 is currently regarded as an important mechanism.
Annett Halle, Doreen Becker, Joerg R. Weber, Olaf Hoffmann, Emilie Dagand, Seija Lehnardt, Dorette Freyer, Johann S. Braun   +7 more
openaire   +3 more sources

Increased Expression of Toll-Like Receptor (TLR) 2 and TLR6 on Peripheral Blood Monocytes by Induction of Staphylococcal Enterotoxin B During Exacerbation of Atopic Dermatitis Patients

Clinical, Cosmetic and Investigational Dermatology, 2023
Fitria Salim,1,2 Hendra Gunawan,3 Oki Suwarsa,3 Endang Sutedja3 1Doctoral Study Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Department of Dermatology and Venereology, Faculty of Medicine, Universitas Syiah Kuala,
Salim F, Gunawan H, Suwarsa O, Sutedja E
doaj  

Evaluation of TlR2 and 4 in Chronic Periodontitis

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2016
Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection due to oral bacteria. Members of Toll-Like Receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharides and activate signalling pathways that result in immune responses against ...
Arulpari Mahalingam, Paavai Ilango, Harinath Parthasarathy, Vineela Katamreddy, Venkat Subbareddy   +4 more
openaire   +3 more sources

TLR2 as a Therapeutic Target in Bacterial Infection

Trends in Molecular Medicine, 2020
Toll-like receptor (TLR) 2 recognizes and responds to threats early in bacterial infections and can influence the downstream immune response to the host's benefit or detriment. Therapeutic modulation of TLR2 signaling represents an underutilized opportunity to moderate the immune response to infection to promote an improved outcome for the host.
Morgan Simpson, William A. Petri
openaire   +4 more sources

Contribution of TLR2 pathway in the pathogenesis of vulvovaginal candidiasis [PDF]

Pathogens and Disease, 2017
Candida albicans is the prevalent etiological agent in acute vulvovaginal infection and the most severe chronic condition known as recurrent vulvovaginal candidiasis (VVC). A critical role of local innate immunity in defense and pathogenesis of vaginal infection by Candida is proposed.
Miró, María Soledad, Rodriguez, Emilse, Vigezzi, Cecilia, Icely, Paula Alejandra, García, Luciana Noemí, Peinetti, Nahuel, Maldonado, Cristina Alicia, Riera, Fernando Oscar, Caeiro, Juan Pablo, Sotomayor, Claudia Elena   +9 more
openaire   +6 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

A Review: The Significance of Toll-Like Receptors 2 and 4, and NF-κB Signaling in Endothelial Cells during Atherosclerosis

Frontiers in Bioscience-Landmark
Atherosclerosis (AS) is a chronic inflammatory vascular disease that begins with endothelial activation followed by a series of inflammatory responses, plaque formation, and finally rupture.
Baoxin Yan, Xiaoxian Yu, Xianzhen Cai, Xiaojun Huang, Bin Xie, Danchun Lian, Jinhao Chen, Weiwen Li, Ying Lin, Junjun Ye, Jilin Li   +10 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Argon Alleviates Bone Cancer Pain by Mitigating Neuronal Ferroptosis via the TLR2-COX-2 Pathway

Frontiers in Bioscience-Landmark
Background: Bone cancer pain (BCP) related neuronal damage is associated with ferroptosis, a regulated cell death dependent on iron. The noble gas argon is known to have neuroprotective effects, reducing neuroinflammation and enhancing
Peipei Kang, Gujun Cong, Xiaowen Meng, Yang Zhang, Haiyan Sun, Lei Wang, Chao Zhang, Junyi Ma, Tong Liu, Fuhai Ji   +9 more
doaj   +1 more source