Results 61 to 70 of about 101,572 (275)

Nanoparticles Decorated Nanotubes: Advanced Local Therapies From Anodized Nanoengineered Titanium Implants

Advanced Functional Materials, EarlyView.
This comprehensive review explores therapeutic titanium implants designed to enhance integration and provide superior antibacterial efficacy. It is focused on anodized titanium implants with titania nanotubes (TNTs) loaded with nanoparticles (NPs) for local therapeutic release, enhancing bioactivity and bactericidal functions.
Divya Chopra, Liwen Zhang, Tianqi Guo, Sašo Ivanovski, Ruirui Qiao, Karan Gulati   +5 more
wiley   +1 more source

Inhibition of TLR2 signaling by small molecule inhibitors targeting a pocket within the TLR2 TIR domain [PDF]

Proceedings of the National Academy of Sciences, 2015
SignificanceExcess Toll-like receptor 2 (TLR2) signaling has been implicated in numerous inflammatory diseases, yet there is no TLR2 inhibitor licensed for human use. Using computer-aided drug design (CADD), we identified a compound, C16H15NO4(C29), and a derivative,ortho-vanillin, that inhibit TLR2 signaling in vitro and in vivo.
Tristan Dyson, Steven Fletcher, Tsan Sam Xiao, Shannon Greene, Pragnesh Mistry, Ryan S. Schwarz, Greg A. Snyder, Michelle H. W. Laird, Vladimir Y. Toshchakov, Stefanie N. Vogel, Alexander D. MacKerell, Jay Chauhan   +11 more
openaire   +2 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Role of TLR2 in lung angiogenesis

The FASEB Journal, 2009
After chronic left pulmonary artery ligation (LPAL) in mice, there is rapid neovascularization of the ischemic lung. We showed increased macrophage‐derived growth factors and a positive correlation between the number of lavaged macrophages and the magnitude of angiogenesis.
Aigul Moldobaeva, Julie Nijmeh, Elizabeth M. Wagner, John Jenkins   +3 more
openaire   +1 more source

VDLIN: A Deep Learning‐Based Platform for Methylcobalamin‐Inspired Immunomodulatory Compound Screening

Advanced Science, EarlyView.
Using the convolutional neural network model VDLIN, Co7 is identified as a promising therapeutic candidate. Co7 demonstrates distinct advantages over MCB by effectively balancing anti‐inflammatory and immune‐stimulatory functions, making it a potential novel approach for immune modulation.
Xuefei Guo, Yang Zhao, Xianle Rong, Chenxi Niu, Shiyu Hu, Qiang Liu, Fuping You   +6 more
wiley   +1 more source

Heterogeneity of host TLR2 stimulation by Staphylocoocus aureus isolates. [PDF]

PLoS ONE, 2014
High lipoprotein expression and potent activation of host Toll-like receptor-2 (TLR2) are characteristic features of the staphylococcal species. Expression of TLR2 in the host is important for clearance of Staphylococcus aureus infection and host ...
Dina Hilmi, Marijo Parcina, Daniel Stollewerk, Jenny Ostrop, Michaele Josten, Alina Meilaender, Ulrich Zaehringer, Thomas A Wichelhaus, Gabriele Bierbaum, Klaus Heeg, Christiane Wolz, Isabelle Bekeredjian-Ding   +11 more
doaj   +1 more source

TLR2-Mediated Cell Stimulation in Bacterial Vaginosis [PDF]

Journal of Lower Genital Tract Disease, 2008
Bacterial vaginosis (BV) is associated with preterm labor, pelvic inflammatory disease (PID) and increased HIV acquisition, although the pathways that mediate these pathological effects have not been elucidated. To determine the presence of Toll-like receptor (TLR)-ligands and their specificity in BV, genital tract fluids were collected from women with
José Antonio Simões, Gregory T. Spear, Richard M. Novak, Debra Mares   +3 more
openaire   +4 more sources

Emodin Alleviates Sepsis‐Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL‐10

Advanced Science, EarlyView.
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu, Yumeng Yan, Meiling Zheng, Mina Zhang, Tengfei Chen, Zhicheng Qu, Yinglu Bai, Shuwen Zhang, Chunming Zhao, Yifan Shi, Yan Lin, Ning Wang, Yunjing Bai, Yating Zhai, Zhaofang Bai, Wei Guo, Qingquan Liu   +16 more
wiley   +1 more source

Association of TLR2 Arg753Gln gene polymorphism with its expression level in nonagenarians with frailty

Медицинская иммунология
TLR2 is an exceptional pattern-recognizing receptor because of its ability to heterodimerise with different types of TLRs, which allows it to recognize a wide range of molecular structures on the surface of pathogens.
S. O. Lukyanova, O. V. Artemieva, E. D. Nasaeva, L. V. Gankovskaya   +3 more
doaj   +1 more source