Results 1 to 10 of about 414,010 (359)

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]

, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda, A Soloaga, A Sommer, Andrew Wingate, B Echtenacher, B Echtenacher, BG Stiles, C Platzer, CA Gogos, Claire E Monk, Claus Johansen, D Rittirsch, DM Dambach, ER Ottosen, F Hildebrand, FY Liew, GR Wiggin, GY Song, H Chi, J Bain, J Darragh, J Han, J Rouse, J Simon C Arthur, Jin Mo Park, JM Park, Joanne Darragh, Joanne McIlrath, JS Arthur, JS Arthur, Julia M Carr, KV Salojin, Lars Iversen, M Brook, M Hammer, M Saraiva, ML Steinhauser, MS Lee, NC Riedamann, NW Freshney, Olga Ananieva, OM Peck-Palmer, P Chen, PC Cheung, PJ Murray, Q Zhao, R Kuhn, Rachel Toth, SE Moreno, SJ O'Keefe, SM Miggin, SQ Latifi, Susana G Santos, T Kawai, T Lang, T van der Poll, VA Beardmore, VS Carl, WJ Hubbard, X Zhang, Y Kalechman, YJ Kang   +61 more
core   +5 more sources

How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis

Frontiers in Immunology, 2023
Recently, a large number of experimenters have found that the pathogenesis of Parkinson’s disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis.
Ziyi Zhang, Ziyi Zhang, Zhihui Liu, Ao Lv, Chenhui Fan   +4 more
doaj   +1 more source

Involvement of Toll-Like Receptor 4 in Decreased Vasopressor Response Following Trauma/Hemorrhagic Shock

Critical Care Explorations, 2021
OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD, Fernando Dos Santos, PhD, Joyce B. Li, MSc, Federico Aletti, PhD, Geert Schmid-Schonbein, PhD, Erik B. Kistler, MD, PhD   +5 more
doaj   +1 more source

Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4 [PDF]

, 2012
The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair.
Adam A. Kubala, Dan Wang, Gregory M. Cooper, James J. Cray, James R. Gilbert, Melissa A. Shaw, Stefan Bereswill, Timothy R. Billiar   +7 more
core   +18 more sources

TLR7 Ligation Inhibits TLR8 Responsiveness in IL-27-Primed Human THP-1 Monocytes and Macrophages

Journal of Innate Immunity, 2021
Regulation of proinflammatory cytokine expression is critical in the face of single-stranded RNA (ssRNA) virus infections. Many viruses, including coronavirus and influenza virus, wreak havoc on the control of cytokine expression, leading to the ...
Natalya Odoardi, Olena Kourko, Carlene Petes, Sameh Basta, Katrina Gee   +4 more
doaj   +1 more source

Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma

Journal of Hematology & Oncology, 2021
Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to current therapies and invariably recurs. Despite some advancements in anti-glioma therapies, patients’ prognosis remains poor.
Yang Xun, Hua Yang, Bozena Kaminska, Hua You   +3 more
doaj   +1 more source

Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions

Molecules, 2022
Toll-interleukin receptor (TIR) domains have emerged as critical players involved in innate immune signaling in humans but are also expressed as potential virulence factors within multiple pathogenic bacteria.
Eunjeong Lee, Jasmina S. Redzic, Travis Nemkov, Anthony J. Saviola, Monika Dzieciatkowska, Kirk C. Hansen, Angelo D’Alessandro, Charles Dinarello, Elan Z. Eisenmesser   +8 more
doaj   +1 more source

Toll-Like Receptor 4 Wild Type Homozygozity of Polymorphisms +896 and +1196 Is Associated with High Gastrin Serum Levels and Peptic Ulcer Risk. [PDF]

PLoS ONE, 2015
Toll-like receptor 4 is a part of the innate immune system and recognizes Helicobacter pylori lipopolysaccharide. The goal of this study was to analyze the role of Toll-like receptor 4 polymorphisms +896 (rs4986790) and +1196 (rs4986791) in the ...
Vesa-Matti Pohjanen, Olli-Pekka Koivurova, Heikki Huhta, Olli Helminen, Johanna M Mäkinen, Jari M Karhukorpi, Tapio Joensuu, Pentti O Koistinen, Jarno M Valtonen, Seppo E Niemelä, Riitta A Karttunen, Tuomo J Karttunen   +11 more
doaj   +1 more source

Role of Toll Like Receptor 4 in Alzheimer’s Disease

Frontiers in Immunology, 2020
Long-term evidence has confirmed the involvement of an inflammatory component in neurodegenerative disorders including Alzheimer’s disease (AD). This view is supported, in part, by data suggesting that selected non-steroidal anti-inflammatory drugs ...
Maria Calvo-Rodriguez, Carmen García-Rodríguez, Carlos Villalobos, Lucía Núñez, Lucía Núñez   +4 more
doaj   +1 more source

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]

, 2016
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core   +4 more sources