Results 1 to 10 of about 393,633 (173)
Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma [PDF]
Journal of Hematology & Oncology, 2021 Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to current therapies and invariably recurs. Despite some advancements in anti-glioma therapies, patients’ prognosis remains poor.
Yang Xun +3 more
doaj +3 more sources
Toll-like receptor signaling pathways [PDF]
Frontiers in Immunology, 2014 Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the
Taro eKawai, Takumi eKawasaki
doaj +3 more sources
Toll-like receptor 5 on monocyte as a biomarker of mortality risk in patients with sepsis [PDF]
BMC Infectious DiseasesObjective To evaluate the expression of Toll-like receptor 5 on monocyte at ICU admission as a potentially novel early screening biomarker to predict the mortality risk of sepsis.
Hong Tan +4 more
doaj +2 more sources
TLR9: A Double-Dealing Toll-Like Receptor [PDF]
ImmunoTargets and TherapyMegan Nielsen,1 Daisuke Nishizaki,2,* Shumei Kato,2,* Razelle Kurzrock1 1Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, USA; 2Moores Cancer Center, University of California San Diego, La Jolla, CA, USA*These ...
Nielsen M +3 more
doaj +2 more sources
Current Biology, 2011 SummaryBeginning with the physical barrier presented by the epithelium, infectious agents such as viruses and bacteria encounter an array of cellular and molecular countermeasures that evolved within the host to resist them. Host immune responses are of two types, termed innate and adaptive.
Moresco, Eva Marie Y. +2 more
+5 more sources
How Toll-like receptors influence Parkinson’s disease in the microbiome–gut–brain axis
Frontiers in Immunology, 2023 Recently, a large number of experimenters have found that the pathogenesis of Parkinson’s disease may be related to the gut microbiome and proposed the microbiome–gut–brain axis.
Ziyi Zhang +4 more
doaj +1 more source
Critical Care Explorations, 2021 OBJECTIVES:. Refractory vascular failure due to the inability of vascular smooth muscle to respond to vasoconstrictors such as phenylephrine is a final common pathway for severe circulatory shock of any cause, including trauma/hemorrhagic shock ...
Rafi Mazor, PhD +5 more
doaj +1 more source
TLR7 Ligation Inhibits TLR8 Responsiveness in IL-27-Primed Human THP-1 Monocytes and Macrophages
Journal of Innate Immunity, 2021 Regulation of proinflammatory cytokine expression is critical in the face of single-stranded RNA (ssRNA) virus infections. Many viruses, including coronavirus and influenza virus, wreak havoc on the control of cytokine expression, leading to the ...
Natalya Odoardi +4 more
doaj +1 more source
Molecules, 2022 Toll-interleukin receptor (TIR) domains have emerged as critical players involved in innate immune signaling in humans but are also expressed as potential virulence factors within multiple pathogenic bacteria.
Eunjeong Lee +8 more
doaj +1 more source
Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4 [PDF]
, 2012 The bone and immune systems are closely interconnected. The immediate inflammatory response after fracture is known to trigger a healing cascade which plays an important role in bone repair.
Adam A. Kubala +7 more
core +13 more sources