Results 21 to 30 of about 393,653 (192)

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. [PDF]

, 2017
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown.
Brennan, Cameron W., Campos, Carl, Clark, Owen, Codega, Paolo, DeAngelis, Lisa M., Dogan, Ahmet, Gavrilovic, Igor T., Glass, Jon, Graeber, Thomas G., Grommes, Christian, Gutin, Philip H., Hamlin, Paul, Hatzoglou, Vaios, Hsieh, Wan-Ying, Huse, Jason T., Kaley, Thomas J., Lallana, Enrico C., Mellinghoff, Ingo K., Moskowitz, Craig H., Nichol, Donna, Nolan, Craig P., Noy, Ariela, Omuro, Antonio, Palaskas, Nicolaos, Palomba, M. Lia, Panageas, Katherine S., Pastore, Alessandro, Peak, Scott, Pentsova, Elena, Reiner, Anne S., Rohle, Dan, Rosenblum, Marc, Sauter, Craig S., Schartz, Derrek, Schultz, Nikolaus, Tabar, Viviane S., Tang, Sarah S., Thomas, Alissa A., Tsyvkin, Elina, Viale, Agnes, Wolfe, Julia, Won, Minhee   +41 more
core   +2 more sources

The phosphoproteome of toll‐like receptor‐activated macrophages

Molecular Systems Biology, 2010
Recognition of microbial danger signals by toll‐like receptors (TLR) causes re‐programming of macrophages. To investigate kinase cascades triggered by the TLR4 ligand lipopolysaccharide (LPS) on systems level, we performed a global, quantitative and ...
Gabriele Weintz, Jesper V Olsen, Katja Frühauf, Magdalena Niedzielska, Ido Amit, Jonathan Jantsch, Jörg Mages, Cornelie Frech, Lars Dölken, Matthias Mann, Roland Lang   +10 more
doaj   +1 more source

Tenascin‐C Aggravates Autoimmune Myocarditis via Dendritic Cell Activation and Th17 Cell Differentiation [PDF]

, 2014
Background Tenascin‐C (TN‐C), an extracellular matrix glycoprotein, appears at several important steps of cardiac development in the embryo, but is sparse in the normal adult heart.
Aonuma Kazutaka, Hiroe Michiaki, Imanaka‐Yoshida Kyoko, Kimura Taizo, Machino‐Ohtsuka Tomoko, Sakai Satoshi, Sato Akira, Tajiri Kazuko, Yasutomi Yasuhiro, Yoshida Toshimichi, 佐藤 明, 田尻 和子, 町野 智子, 酒井 俊, 青沼 和隆   +14 more
core   +1 more source

Immunological study of orthodontically treated patients recovering from COVID-19 in Babylon Province, Iraq

Medical Journal of Babylon, 2023
Background and Objectives: This study aimed to examine the levels of the toll-like receptors TLR4 and TLR2 in the blood and saliva of patients with coronavirus disease-2019 (COVID-19) receiving orthodontic care in Babylon Province. Materials and Methods:
Basma Abdel Khaleq Eidan, Thaer Jaber Al-Khafaji, Ahmed Mohammed Abbas   +2 more
doaj   +1 more source

Chemoproteomics reveals Toll-like receptor fatty acylation [PDF]

, 2014
Partial funding for Open Access provided by The Ohio State University Open Access Fund.Background: Palmitoylation is a 16-carbon lipid post-translational modification that increases protein hydrophobicity.
A Bafica, AF Roth, AI Su, AI Su, BA Merrick, Balyn W Zaro, BH Zheng, BR Martin, BR Martin, C Aicart-Ramos, C Ivaldi, C Salaun, C Wu, CB Lopez, CB Lopez, CT Tom, D Davda, D Rotin, E Latz, E Lorenz, F Sandor, G Charron, G Charron, GJ Freeman, H Kato, HC Hang, Howard C Hang, J Charollais, J Greaves, J Greaves, J Ren, Jacob S Yount, James L Chen, JC Hach, JL Hernandez, Joanne Turner, Jocelyn C Hach, JP Wilson, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, JS Yount, KJ Brandt, L Dowal, Larry S Schlesinger, M Fukata, M Muzio, M Scheffner, M Triantafilou, M Yamamoto, MA Imro, Matthew R Pratt, ME Linder, Murugesan VS Rajaram, Nicholas M Chesarino, NT Thuong, O Takeuchi, P Hollsberg, P Mill, R Barbalat, R Kang, R Tsutsumi, RM Steinman, RN Hannoush, S Blaskovic, S Borrello, S Kupzig, SC Henry, T Kawai, T Kawai, TR Hawn, Y Bulut, Y Fukata, Y Li, Y Webb, YY Yang, Z Jiang   +80 more
core   +2 more sources

Toll-like receptor 2 and Toll-like receptor 4 predict favorable prognosis in local pancreatic cancer

Tumor Biology, 2018
Toll-like receptors play an essential role in our innate immune system and are a focus of interest in contemporary cancer research. Thus far, Toll-like receptors have shown promising prognostic value in carcinomas of the oral cavity, colon, and ovaries ...
Mira A Lanki, Hanna E Seppänen, Harri K Mustonen, Camilla Böckelman, Anne T Juuti, Jaana K Hagström, Caj H Haglund   +6 more
doaj   +1 more source

Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart [PDF]

, 2007
Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Blecha, Frank, Linde, Annika, Melgarejo, Tonatiuh   +2 more
core   +2 more sources

Toll-like receptor

Japanese Journal of Clinical Immunology, 2005
Toll-like receptors (TLRs) have been revealed to recognize specific patterns of microbial components. Recognition of microbial components by TLRs initiates signal transduction pathways, triggering expression of genes, which products control innate immune responses and further instruct development of antigen-specific acquired immunity.
openaire   +4 more sources

Toll-Like Receptors

Türk Yoğun Bakim Derneği Dergisi, 2012
Mammals sense pathogen invasion through pattern-recognition receptors (PRRs). A group of transmembrane proteins, Toll-like receptors (TLRs) are mainly expressed on antigen-presenting cells, such as macrophages or dendritic cells, and play critical roles as PRRs (1).
Shin, Ho Sik, Jung, Yeon Soon, Rim, Hark
  +5 more sources

Alveolar macrophages and Toll-like receptor 4 mediate ventilated lung ischemia reperfusion injury in mice. [PDF]

, 2012
BackgroundIschemia-reperfusion (I-R) injury is a sterile inflammatory process that is commonly associated with diverse clinical situations such as hemorrhage followed by resuscitation, transient embolic events, and organ transplantation.
Dodd-o, Jeffrey M, Hellman, Judith, Mesa, Kailin R, Prakash, Arun, Wilhelmsen, Kevin, Xu, Fengyun   +5 more
core   +1 more source