Results 1 to 10 of about 213,704 (149)

Toll-like receptor 3: a double-edged sword [PDF]

Biomarker Research
The discovery of Toll-like receptors (TLRs) and their role in dendritic cells earned the Nobel Prize for 2011 because TLRs profoundly enhanced our understanding of the immune system.
Marvin L Hsieh, Daisuke Nishizaki, Jacob J Adashek, Shumei Kato, Razelle Kurzrock   +4 more
doaj   +4 more sources

Roles of Toll-Like Receptor 3 in Human Tumors [PDF]

Frontiers in Immunology, 2021
Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons ...
Xin Zheng, Song Li, Hui Yang
doaj   +5 more sources

Toll-Like receptor 3 genetic polymorphism in dengue encephalitis [PDF]

Journal of Family Medicine and Primary Care
Context: Dengue is one of the important vector-borne viral diseases affecting humans with diverse manifestations. Toll-like receptors (TLR) are pattern recognition receptors and play an important role in innate immunity against microbes.
Rajesh Verma, Atul K. Pandey, Rajarshi Chakraborty, Shantanu Prakash, Amita Jain   +4 more
doaj   +4 more sources

Avian Toll-like receptor 3 isoforms and evaluation of Toll-like receptor 3–mediated immune responses using knockout quail fibroblast cells [PDF]

Poultry Science, 2020
Toll-like receptor 3 (TLR3) induces host innate immune response on recognition of viral double-stranded RNA (dsRNA). Although several studies of avian TLR3 have been reported, none of these studies used a gene knockout (KO) model to directly assess its ...
Mahesh KC, John M. Ngunjiri, Joonbum Lee, Jinsoo Ahn, Mohamed Elaish, Amir Ghorbani, Michael E.C. Abundo, Kichoon Lee, Chang-Won Lee   +8 more
doaj   +4 more sources

Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis [PDF]

Cell Death and Disease, 2022
Osteoarthritis (OA) is characterized by cartilage degradation that is induced by inflammation. Sterile inflammation can be caused by damage-associated molecular patterns that are released by chondrocytes and activate pattern recognition receptors.
Josef Stolberg-Stolberg, Annika Boettcher, Meike Sambale, Sina Stuecker, Joanna Sherwood, Michael Raschke, Thomas Pap, Jessica Bertrand   +7 more
doaj   +5 more sources

Toll-Like Receptor 3 in Liver Diseases [PDF]

Gastroenterology Research and Practice, 2010
Toll-like receptor 3 (TLR3) is a member of the TLR family that can recognize double-stranded RNA (dsRNA), playing an important role in antiviral immunity.
Shi Yin, Bin Gao
doaj   +4 more sources

Anti‐pruritic effect of isothiocyanates: Potential involvement of toll‐like receptor 3 signaling [PDF]

Pharmacology Research & Perspectives, 2022
The innate immune system has an emerging role as a mediator of neuro‐immune communication and a therapeutic target for itch. Toll‐like receptor 3 (TLR3) plays an important role in itch, as shown in TLR3 knock‐out mice.
Masaki Moriyama, Mitsuhiro Konno, Kanako Serizawa, Natsumi Yuzawa, Yuki Majima, Ikuo Hayashi, Tomohiko Suzuki, Mie Kainoh   +7 more
doaj   +2 more sources

Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and mice. [PDF]

PLoS ONE, 2012
Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal immune system activation, inflammation, and endothelial dysfunction.
Piyali Chatterjee, Laura E Weaver, Karen M Doersch, Shelley E Kopriva, Valorie L Chiasson, Samantha J Allen, Ajay M Narayanan, Kristina J Young, Kathleen A Jones, Thomas J Kuehl, Brett M Mitchell   +10 more
doaj   +4 more sources

Extracellular RNA Induces Neutrophil Recruitment Via Toll‐Like Receptor 3 During Venous Thrombosis After Vascular Injury [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Venous thromboembolism is associated with endothelial cell activation that contributes to the inflammation‐dependent activation of the coagulation system. Cellular damage is associated with the release of different species of extracellular RNA
Maria Y. Najem, Ryan N. Rys, Sandrine Laurance, François‐René Bertin, Virginie Gourdou‐Latyszenok, Lénaïck Gourhant, Lauriane Le Gall, Rozenn Le Corre, Francis Couturaud, Mark D. Blostein, Catherine A. Lemarié   +10 more
doaj   +2 more sources

Role of Toll-Like Receptor 3 Gene Polymorphisms in Preeclampsia [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: Accumulating evidence suggests that an excessive maternal systemic inflammatory response to pregnancy with exaggerated activation of the innate immune system plays a critical role in the development of preeclampsia (PE).
Aiping Chen, Congying Li, Jingli Wang, Han Sha, Shunfu Piao, Shiguo Liu   +5 more
doaj   +3 more sources