Toll‑like receptor 3 ligands for breast cancer therapies (Review). [PDF]
Mol Clin Oncol, 2023 Breast cancer is the most common cause of cancer worldwide and is the leading cause of mortality for women across most of the world. Immunotherapy is a burgeoning area of cancer treatment, including for breast cancer; these are therapies that harness the power of the immune system to clear cancerous cells. Toll-like receptor 3 (TLR3) is an RNA receptor
Butkowsky C, Aldor N, Poynter SJ.
europepmc +3 more sources
TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization [PDF]
Microbial Cell, 2023 Toll-like receptor 3 (TLR3) is an innate immune receptor that recognizes double-stranded RNA (dsRNA) and induces inflammation in immune and normal cells to initiate anti-microbial responses. TLR3 acts also as a death receptor only in cancer cells but not
Sylvain Thierry +12 more
doaj +2 more sources
Toll-like receptor 3 signaling attenuated colitis-associated cancer development in mice [PDF]
Scientific ReportsInflammatory bowel disease is associated with a high risk of colitis-associated cancer (CAC). We evaluated the role of TLR3 in CAC using a murine model.
Kee Young Chung +9 more
doaj +2 more sources
Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy [PDF]
Acta Pharmaceutica Sinica B, 2022 Toll-like receptor 3 (TLR3), as an important pattern recognition receptor (PRR), dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.
Xiaohong Cen +9 more
doaj +2 more sources
Toll-Like Receptor 3 in Solid Cancer and Therapy Resistance. [PDF]
Cancers (Basel), 2020 Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been extensively studied for its antiviral function. It is highly expressed in the endosomes of antigen-presenting immune cells and epithelial cells. TLR3 binds specifically double-strand RNAs (dsRNAs), leading to the activation of mainly two downstream pathways: the phosphorylation ...
Muresan XM +3 more
europepmc +4 more sources
Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]
, 2015 The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia +7 more
core +11 more sources
Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses [PDF]
Microbiology and Immunology, 2004 AbstractProduction of type I interferon (IFN‐α/β) by virus‐infected cells is the central event in their antiviral immune responses. In mammalian cells, IFN‐α/β gene transcription is induced through distinct signaling pathways by viral infection or by treatment with double‐stranded (ds) RNA, which is an intermediate of virus replication.
Misako, Matsumoto +3 more
openaire +2 more sources
Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression [PDF]
, 2009 The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders.
Aghabarari, A. +8 more
core +3 more sources
The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells
Sakarya Tıp Dergisi, 2021 Objective: Prostate cancer accounts for approximately 10% of new cases diagnosed in men worldwide. Toll like receptors (TLRs) play a crucial role in the progression of cancer.
Gamze Güney Eskiler +5 more
doaj +1 more source
Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 4 [PDF]
The Journal of Immunology, 2003 Abstract We have recently described an IFN regulatory factor 3-mediated antiviral gene program that is induced by both Toll-like receptor (TLR)3 and TLR4 ligands. In our current study, we show that activation of IFN/viral response gene expression in primary macrophage cells is stronger and prolonged with TLR3 stimulation compared with ...
Sean E, Doyle +5 more
openaire +2 more sources