Toll‑like receptor 3 ligands for breast cancer therapies (Review). [PDF]
Mol Clin Oncol, 2023 Breast cancer is the most common cause of cancer worldwide and is the leading cause of mortality for women across most of the world. Immunotherapy is a burgeoning area of cancer treatment, including for breast cancer; these are therapies that harness the power of the immune system to clear cancerous cells. Toll-like receptor 3 (TLR3) is an RNA receptor
Butkowsky C, Aldor N, Poynter SJ.
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TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization [PDF]
Microbial Cell, 2023 Toll-like receptor 3 (TLR3) is an innate immune receptor that recognizes double-stranded RNA (dsRNA) and induces inflammation in immune and normal cells to initiate anti-microbial responses. TLR3 acts also as a death receptor only in cancer cells but not
Sylvain Thierry +12 more
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Toll-like receptor 3 signaling attenuated colitis-associated cancer development in mice [PDF]
Scientific ReportsInflammatory bowel disease is associated with a high risk of colitis-associated cancer (CAC). We evaluated the role of TLR3 in CAC using a murine model.
Kee Young Chung +9 more
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Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy [PDF]
Acta Pharmaceutica Sinica B, 2022 Toll-like receptor 3 (TLR3), as an important pattern recognition receptor (PRR), dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.
Xiaohong Cen +9 more
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Toll-Like Receptor 3 in Solid Cancer and Therapy Resistance. [PDF]
Cancers (Basel), 2020 Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been extensively studied for its antiviral function. It is highly expressed in the endosomes of antigen-presenting immune cells and epithelial cells. TLR3 binds specifically double-strand RNAs (dsRNAs), leading to the activation of mainly two downstream pathways: the phosphorylation ...
Muresan XM +3 more
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Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses [PDF]
Microbiology and Immunology, 2004 AbstractProduction of type I interferon (IFN‐α/β) by virus‐infected cells is the central event in their antiviral immune responses. In mammalian cells, IFN‐α/β gene transcription is induced through distinct signaling pathways by viral infection or by treatment with double‐stranded (ds) RNA, which is an intermediate of virus replication.
Misako, Matsumoto +3 more
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The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells
Sakarya Tıp Dergisi, 2021 Objective: Prostate cancer accounts for approximately 10% of new cases diagnosed in men worldwide. Toll like receptors (TLRs) play a crucial role in the progression of cancer.
Gamze Güney Eskiler +5 more
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Toll-Like Receptor 3 Mediates a More Potent Antiviral Response Than Toll-Like Receptor 4 [PDF]
The Journal of Immunology, 2003 Abstract We have recently described an IFN regulatory factor 3-mediated antiviral gene program that is induced by both Toll-like receptor (TLR)3 and TLR4 ligands. In our current study, we show that activation of IFN/viral response gene expression in primary macrophage cells is stronger and prolonged with TLR3 stimulation compared with ...
Sean E, Doyle +5 more
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PM2.5 increases mouse blood pressure by activating toll-like receptor 3
Ecotoxicology and Environmental Safety, 2022 Background and aims: Plenty of literature has documented that fine particulate matter (PM2.5) exposure is related to blood pressure (BP) elevation. Vascular dysfunction is the initiation of cardiovascular diseases, such as hypertension.
Jinna Zhang +10 more
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Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. [PDF]
PLoS ONE, 2013 Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury.
Karen A Cavassani +13 more
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