Results 21 to 30 of about 213,803 (247)
The Toll-like receptor 3:dsRNA signaling complex [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2009 Toll-like receptors (TLRs) recognize conserved molecular patterns in invading pathogens and trigger innate immune responses. TLR3 recognizes dsRNA, a molecular signature of most viruses via its ectodomain (ECD). The TLR3-ECD structure consists of a 23 turn coil bent into the shape of a horseshoe with specialized domains capping the N and C-terminal ...
Istvan, Botos +4 more
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Toll-like receptor 3 signaling attenuates liver regeneration # [PDF]
Hepatology, 2009 Abstract The current model for liver regeneration suggests that cell damage triggers Toll-like receptor (TLR) signaling via MyD88, leading to the induction of nuclear factor κB (NF-κB) and secretion of inflammatory cytokines that in turn prime liver regeneration.
Elina, Zorde-Khvalevsky +7 more
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Frontiers in Immunology, 2022 Risk stratification for cytomegalovirus (CMV) infection after kidney transplantation (KT) remains to be determined. Since endosomal toll-like receptors (TLRs) are involved in viral sensing, we investigated the impact of common single-nucleotide ...
Natalia Redondo +25 more
doaj +1 more source
Predicting novel features of toll-like receptor 3 signaling in macrophages. [PDF]
PLoS ONE, 2009 The Toll-like receptor (TLR) 3 plays a critical role in mammalian innate immune response against viral attacks by recognizing double-stranded RNA (dsRNA) or its synthetic analog polyinosinic-polycytidylic acid (poly (IratioC)).
Mohamed Helmy +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Chikungunya virus (CHIKV) is the etiological agent of chikungunya fever (CHIKF), a self-limiting disease characterized by myalgia and severe acute or chronic arthralgia. CHIKF is associated with immunopathology and high levels of pro-inflammatory factors.
Juan Felipe Valdés-López +2 more
doaj +1 more source
Spinal toll like receptor 3 is involved in chronic pancreatitis-induced mechanical allodynia of rat
Molecular Pain, 2011 Background Mechanisms underlying pain in chronic pancreatitis (CP) are incompletely understood. Our previous data showed that astrocytes were actively involved. However, it was unclear how astrocytic activation was induced in CP conditions.
Feng Quan-Xing +5 more
doaj +1 more source
Toll-like Receptor 3 Activation Decreases Porcine Arterivirus Infection [PDF]
Viral Immunology, 2008 Porcine reproductive and respiratory syndrome virus (PRRSV) is an RNA virus that initiates infection in pulmonary alveolar macrophages (PAMs), elicits weak immune responses, and establishes a persistent infection. To understand the role of dsRNA intermediates in eliciting host immunity, we sought to determine if toll-like receptor-3 (TLR3), a well ...
Yongming, Sang +3 more
openaire +2 more sources
Haematologica, 2016 Murine models of red blood cell transfusion show that inflammation associated with viruses or methylated DNA promotes red blood cell alloimmunization.
Rahma Elayeb +4 more
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Polyinosinic Acid Is a Ligand for Toll-like Receptor 3 [PDF]
Journal of Biological Chemistry, 2007 Innate immune responses are critical in controlling viral infections. Viral proteins and nucleic acids have been shown to be recognized by pattern recognition receptors of the Toll-like receptor (TLR) family, triggering downstream signaling cascades that lead to cellular activation and cytokine production.
Marshall-Clarke, Stuart +7 more
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The dsRNA binding site of human Toll-like receptor 3 [PDF]
Proceedings of the National Academy of Sciences, 2006 Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. The TLRs recognize pathogens with their N-terminal ectodomains (ECD), but the molecular basis for this recognition is not known.
Jessica K, Bell +4 more
openaire +2 more sources