Results 31 to 40 of about 213,803 (247)

Modeling of the Toll‐like receptor 3 and a putative Toll‐like receptor 3 antagonist encoded by the African swine fever virus [PDF]

Protein Science, 2011
AbstractAfrican swine fever virus (ASFV) is a large double‐stranded DNA virus responsible for a lethal pig disease, to which no vaccine has ever been obtained. Its genome encodes a number of proteins involved in virus survival and transmission in its hosts, in particular proteins that inhibit signaling pathways in infected macrophages and, thus ...
Henriques, Elsa S, Brito, Rui M M, Soares, Hugo, Ventura, Sónia, de Oliveira, Vivian L, Parkhouse, R Michael E   +5 more
openaire   +2 more sources

Clostridium butyricum Helps to Alleviate Inflammation in Weaned Piglets Challenged With Enterotoxigenic Escherichia coli K88

Frontiers in Veterinary Science, 2021
Background: Whether the probiotic Clostridium butyricum (CB) alleviates enterotoxigenic Escherichia coli (ETEC) K88-induced inflammation by regulating the activation of the toll-like receptor (TLR) signaling pathway is not clear, thus, we carried out ...
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao   +3 more
doaj   +1 more source

Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells

Journal of Biomedical Science, 2011
Background Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system.
Du Yung-Ying, Wu Chia-Ling, Huang Chao-Cheng, Chuang Hui-Ching, Chuang Jiin-Haur, Kung Mei-Lang, Chen Chih-Hao, Chen San-Cher, Tai Ming-Hong   +8 more
doaj   +1 more source

Staphylococcus aureus increases Prostaglandin E2 secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways

Frontiers in Microbiology, 2023
IntroductionIn clinical settings, dairy cows are often attacked by pathogenic bacteria after delivery, especially Staphylococcus aureus (S. aureus). Neutrophils have long been regarded as essential for host defense against S. aureus.
Kai Zhang, Kai Zhang, Yan Jia, Yan Jia, Yinghong Qian, Xueying Jiang, Xueying Jiang, Shuangyi Zhang, Shuangyi Zhang, Bo Liu, Bo Liu, Jinshan Cao, Jinshan Cao, Yongli Song, Wei Mao, Wei Mao   +15 more
doaj   +1 more source

LncRNA CRNDE triggers inflammation through the TLR3-NF-κB-Cytokine signaling pathway

Tumor Biology, 2017
Colorectal neoplasia differentially expressed (CRNDE), an oncogene, is highly expressed in many tumor cells and affects cellular proliferation, migration, invasion, and apoptosis. Its function and mechanism of action is a research hotspot. In this study,
Haowen Li, Qi Li, Tao Guo, Wenyan He, Chengya Dong, Yajie Wang   +5 more
doaj   +1 more source

Choroidal Neovascular Membranes Express Toll-Like Receptor 3

Ophthalmic Research, 2010
<i>Background:</i> Recent evidence has suggested a role for toll-like receptor 3 (TLR3) in experimental models of age-related macular degeneration (AMD). To date, however, few data exist about TLR3 in human AMD. The purpose of this study was to investigate the expression of TLR3 in human choroidal neovascular (CNV) membranes.
Shawn C, Maloney, Emilia, Antecka, Maria E, Orellana, Bruno F, Fernandes, Alexandre N, Odashiro, Masoomeh, Eghtedari, Miguel N, Burnier   +6 more
openaire   +2 more sources

Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy

Frontiers in Immunology, 2017
Pattern recognition receptors (PRRs) play a crucial role in the innate immune system and contribute to host defense against microbial infection. PRR-mediated antimicrobial signals provide robust type-I IFN/cytokine production and trigger inflammation ...
Misako Matsumoto, Yohei Takeda, Megumi Tatematsu, Tsukasa Seya   +3 more
doaj   +1 more source

Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production [PDF]

Immunity, 2016
Metagenomic studies show that diverse resident viruses inhabit the healthy gut; however, little is known about the role of these viruses in the maintenance of gut homeostasis. We found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice.
Jin-Young, Yang, Min-Soo, Kim, Eugene, Kim, Jae Hee, Cheon, Yong-Soo, Lee, Yeji, Kim, Su-Hyun, Lee, Sang-Uk, Seo, Seung-Ho, Shin, Sun Shim, Choi, Bumseok, Kim, Sun-Young, Chang, Hyun-Jeong, Ko, Jin-Woo, Bae, Mi-Na, Kweon   +14 more
openaire   +3 more sources

Characterizing Parental Concerns About Lasting Impacts of Treatment in Children With B‐Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background B‐acute lymphoblastic leukemia (B‐ALL) is the most common pediatric cancer, and while most children in high‐resource settings are cured, therapy carries risks for long‐term toxicities. Understanding parents’ concerns about these late effects is essential to guide anticipatory support and inform evolving therapeutic approaches ...
Kellee N. Parker, Sarah W. Alexander, Lisa M. Jacola, Kimberly A. Buff, Kyobin Hwang, Elham Hashemi, Gregory Stoddard, Lindsay A. Jibb   +7 more
wiley   +1 more source

Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice

JACC: Basic to Translational Science, 2019
Summary: Mitochondrial deoxyribonucleic acid, containing the unmethylated cytidine-phosphate-guanosine motif, stimulates Toll-like receptor 9 to induce inflammation and heart failure.
Hiromichi Ueda, MD, Osamu Yamaguchi, MD, PhD, Manabu Taneike, MD, PhD, Yasuhiro Akazawa, MD, Haruko Wada-Kobayashi, MD, Ryuta Sugihara, MD, Hiroki Yorifuji, MD, Hiroyuki Nakayama, MD, PhD, Shigemiki Omiya, MD, PhD, Tomokazu Murakawa, MD, PhD, Yasushi Sakata, MD, PhD, Kinya Otsu, MD, PhD   +11 more
doaj   +1 more source