Results 41 to 50 of about 349,446 (189)

The dsRNA binding site of human Toll-like receptor 3 [PDF]

Proceedings of the National Academy of Sciences, 2006
Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. The TLRs recognize pathogens with their N-terminal ectodomains (ECD), but the molecular basis for this recognition is not known.
Jessica K, Bell, Janine, Askins, Pamela R, Hall, David R, Davies, David M, Segal   +4 more
openaire   +2 more sources

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis [PDF]

, 2008
OBJECTIVE: To analyze the expression, regulation, and biologic relevance of Toll-like receptors (TLRs) 1-10 in synovial and skin fibroblasts and to determine the expression levels of TLRs 2, 3, and 4 in synovial tissues from patients with early ...
Brentano, F, Gay, R E, Gay, S, Kolling, C, Kyburz, D, Ospelt, C, Rengel, Y, Stanczyk, J, Tak, P P   +8 more
core   +2 more sources

Modeling of the Toll‐like receptor 3 and a putative Toll‐like receptor 3 antagonist encoded by the African swine fever virus [PDF]

Protein Science, 2011
AbstractAfrican swine fever virus (ASFV) is a large double‐stranded DNA virus responsible for a lethal pig disease, to which no vaccine has ever been obtained. Its genome encodes a number of proteins involved in virus survival and transmission in its hosts, in particular proteins that inhibit signaling pathways in infected macrophages and, thus ...
Henriques, Elsa S, Brito, Rui M M, Soares, Hugo, Ventura, Sónia, de Oliveira, Vivian L, Parkhouse, R Michael E   +5 more
openaire   +2 more sources

Clostridium butyricum Helps to Alleviate Inflammation in Weaned Piglets Challenged With Enterotoxigenic Escherichia coli K88

Frontiers in Veterinary Science, 2021
Background: Whether the probiotic Clostridium butyricum (CB) alleviates enterotoxigenic Escherichia coli (ETEC) K88-induced inflammation by regulating the activation of the toll-like receptor (TLR) signaling pathway is not clear, thus, we carried out ...
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao   +3 more
doaj   +1 more source

Toll-like receptor 3 blockade in rhinovirus-induced experimental asthma exacerbations:A Randomized Controlled Study [PDF]

, 2017
BACKGROUND: Human rhinoviruses (HRVs) commonly precipitate asthma exacerbations. Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, driving inflammation that can worsen asthma.
Backer, Vibeke, Baribaud, Frédéric, Barnathan, Elliot S., Branigan, Patrick, Del Vecchio, Alfred M., Diamant, Zuzana, Eich, Andreas, Flavin, Susan, Gern, James E., Gordon, Robert, Halperin, Scott A., Herzmann, Christian, Johnston, Sebastian L., Lipworth, Brian J., Loza, Mathew J., Lutter, Rene, Mensinga, Tjeert T., Proud, David, San Mateo, Lani, Silkoff, Philip E., Singh, Dave, Sterk, Peter J., Turner, Ronald B.   +22 more
core   +3 more sources

Staphylococcus aureus increases Prostaglandin E2 secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways

Frontiers in Microbiology, 2023
IntroductionIn clinical settings, dairy cows are often attacked by pathogenic bacteria after delivery, especially Staphylococcus aureus (S. aureus). Neutrophils have long been regarded as essential for host defense against S. aureus.
Kai Zhang, Kai Zhang, Yan Jia, Yan Jia, Yinghong Qian, Xueying Jiang, Xueying Jiang, Shuangyi Zhang, Shuangyi Zhang, Bo Liu, Bo Liu, Jinshan Cao, Jinshan Cao, Yongli Song, Wei Mao, Wei Mao   +15 more
doaj   +1 more source

Streptococcus pneumoniae stabilizes tumor necrosis factor α mRNA through a pathway dependent on p38 MAPK but independent of Toll-like receptors [PDF]

, 2008
Background Streptococcus pneumoniae is a human pathogenic bacteria and a major cause of severe invasive diseases, including pneumonia, bacteremia, and meningitis. Infections with S.
Trine H Mogensen, Randi S Berg, Lars Østergaard, Søren R Paludan   +3 more
core   +2 more sources

LncRNA CRNDE triggers inflammation through the TLR3-NF-κB-Cytokine signaling pathway

Tumor Biology, 2017
Colorectal neoplasia differentially expressed (CRNDE), an oncogene, is highly expressed in many tumor cells and affects cellular proliferation, migration, invasion, and apoptosis. Its function and mechanism of action is a research hotspot. In this study,
Haowen Li, Qi Li, Tao Guo, Wenyan He, Chengya Dong, Yajie Wang   +5 more
doaj   +1 more source

Lack of interferon response in animals to naked siRNAs [PDF]

, 2004
RNA interference (RNAi) is rapidly becoming the method of choice for the elucidation of gene function and the identification of drug targets. As with other oligonucleotide-based strategies, RNAi is envisioned to ultimately be useful as a human ...
Davis, Mark E., Heidel, Jeremy D., Hu, Siwen, Liu, Xian Fang, Triche, Timothy J.   +4 more
core   +2 more sources

Choroidal Neovascular Membranes Express Toll-Like Receptor 3

Ophthalmic Research, 2010
<i>Background:</i> Recent evidence has suggested a role for toll-like receptor 3 (TLR3) in experimental models of age-related macular degeneration (AMD). To date, however, few data exist about TLR3 in human AMD. The purpose of this study was to investigate the expression of TLR3 in human choroidal neovascular (CNV) membranes.
Shawn C, Maloney, Emilia, Antecka, Maria E, Orellana, Bruno F, Fernandes, Alexandre N, Odashiro, Masoomeh, Eghtedari, Miguel N, Burnier   +6 more
openaire   +2 more sources