Results 51 to 60 of about 349,446 (189)

Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy

Frontiers in Immunology, 2017
Pattern recognition receptors (PRRs) play a crucial role in the innate immune system and contribute to host defense against microbial infection. PRR-mediated antimicrobial signals provide robust type-I IFN/cytokine production and trigger inflammation ...
Misako Matsumoto, Yohei Takeda, Megumi Tatematsu, Tsukasa Seya   +3 more
doaj   +1 more source

Investigation of the role of endosomal Toll-like receptors in murine collagen-induced arthritis reveals a potential role for TLR7 in disease maintenance [PDF]

, 2012
INTRODUCTION Endosomal toll-like receptors (TLRs) have recently emerged as potential contributors to the inflammation observed in human and rodent models of rheumatoid arthritis (RA).
Alzabin, Saba, Kong, Philip, Medghalchi, Mino, Palfreeman, Andrew, Sacre, Sandra, Williams, Richard   +5 more
core   +1 more source

NF-{kappa}B-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses [PDF]

, 2006
Activation of mammalian innate and acquired immune responses must be tightly regulated by elaborate mechanisms to control their onset and termination. MicroRNAs have been implicated as negative regulators controlling diverse biological processes at the ...
Baltimore, David, Boldin, Mark P., Chang, Kuang-Jung, Taganov, Konstantin D.   +3 more
core  

Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production [PDF]

Immunity, 2016
Metagenomic studies show that diverse resident viruses inhabit the healthy gut; however, little is known about the role of these viruses in the maintenance of gut homeostasis. We found that mice treated with antiviral cocktail displayed more severe dextran sulfate sodium (DSS)-induced colitis compared with untreated mice.
Jin-Young, Yang, Min-Soo, Kim, Eugene, Kim, Jae Hee, Cheon, Yong-Soo, Lee, Yeji, Kim, Su-Hyun, Lee, Sang-Uk, Seo, Seung-Ho, Shin, Sun Shim, Choi, Bumseok, Kim, Sun-Young, Chang, Hyun-Jeong, Ko, Jin-Woo, Bae, Mi-Na, Kweon   +14 more
openaire   +3 more sources

Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice

JACC: Basic to Translational Science, 2019
Summary: Mitochondrial deoxyribonucleic acid, containing the unmethylated cytidine-phosphate-guanosine motif, stimulates Toll-like receptor 9 to induce inflammation and heart failure.
Hiromichi Ueda, MD, Osamu Yamaguchi, MD, PhD, Manabu Taneike, MD, PhD, Yasuhiro Akazawa, MD, Haruko Wada-Kobayashi, MD, Ryuta Sugihara, MD, Hiroki Yorifuji, MD, Hiroyuki Nakayama, MD, PhD, Shigemiki Omiya, MD, PhD, Tomokazu Murakawa, MD, PhD, Yasushi Sakata, MD, PhD, Kinya Otsu, MD, PhD   +11 more
doaj   +1 more source

TOB1 attenuates IRF3-directed antiviral responses by recruiting HDAC8 to specifically suppress IFN-β expression

Communications Biology, 2022
TOB1 is identified as an interferon regulatory factor 3 (IRF3) binding partner that operates as a negative feedback inhibitor of IFNβ in toll-like receptor and cytosolic nucleic acid receptor sensing pathways.
Zhongxia Yu, Lijuan Wang, Jing Zhao, Hui Song, Chunyuan Zhao, Wei Zhao, Mutian Jia   +6 more
doaj   +1 more source

The nucleotide-binding domain and leucine-rich repeat protein-3 inflammasome is not activated in airway smooth muscle upon toll-like receptor-2 ligation [PDF]

, 2013
Inflammasomes have emerged as playing key roles in inflammation and innate immunity. A growing body of evidence has suggested that the nucleotide-binding domain and leucine-rich repeat protein-3 (NLRP3) inflammasomeisimportant inchronic airwaydiseases ...
Alkhouri, H, Ammit, AJ, Bunge, K, Hirota, JA, Im, H, Manetsch, M, Oliver, BG, Pascoe, CD, Rahman, MM, Rumzhum, NN   +9 more
core   +1 more source

Pattern-recognition receptors in endometriosis: A narrative review

Frontiers in Immunology, 2023
Endometriosis is closely associated with ectopic focal inflammation and immunosuppressive microenvironment. Multiple types of pattern recognition receptors (PRRs) are present in the innate immune system, which are able to detect pathogen-associated ...
Bao Guo, Jia hua Chen, Jun hui Zhang, Yuan Fang, Xiao jing Liu, Jing Zhang, Hai qing Zhu, Lei Zhan   +7 more
doaj   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Toll-like receptor 3 modulates the behavioral effects of cocaine in mice

Journal of Neuroinflammation, 2018
Background The nucleus accumbens in the midbrain dopamine limbic system plays a key role in cocaine addiction. Toll-like receptors (TLRs) are important pattern-recognition receptors (PPRs) in the innate immune system that are also involved in drug ...
Ruiming Zhu, Qian Bu, Dengqi Fu, Xue Shao, Linhong Jiang, Wei Guo, Bo Chen, Bin Liu, Zhengtao Hu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen   +11 more
doaj   +1 more source