Results 51 to 60 of about 213,803 (247)

3-(5-Hydroxyphenyl)-5-Phenyl-2-Pyrazolines as Toll-Like Receptor 7 Agonists

Journal of Chemistry, 2023
Toll-like receptor 7 (TLR7) is an attractive target for developing immune modulators to enhance innate immunity against ssRNA virus infections, including hepatitis C and COVID-19.
Ji Hwan Kim, Seunghyun Ahn, Dongsoo Koh, Young Han Lee, Yoongho Lim, Soon Young Shin   +5 more
doaj   +1 more source

Neuroprotective Effect of Fisetin Through Suppression of IL-1R/TLR Axis and Apoptosis in Pentylenetetrazole-Induced Kindling in Mice

Frontiers in Neurology, 2021
Epilepsy is a complex neurological disorder, characterized by frequent electrical activity in brain regions. Inflammation and apoptosis cascade activation are serious neurological sequelae during seizures.
Saima Khatoon, Nidhi Bharal Agarwal, Mohammed Samim, Ozair Alam   +3 more
doaj   +1 more source

Toll‐like receptor 3 in viral pathogenesis: friend or foe? [PDF]

Immunology, 2013
SummaryViral infections frequently induce acute and chronic inflammatory diseases, yet the contribution of the innate immune response to a detrimental host response remains poorly understood. In virus‐infected cells, double‐stranded RNA (dsRNA) is generated as an intermediate during viral replication. Cell necrosis (and the release of endogenous dsRNA)
Perales-Linares, Renzo, Navas-Martin, Sonia   +1 more
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Functional Mechanisms of Toll-Like Receptor 3 and Its Implications in Digestive System Tumors

Frontiers in Bioscience-Landmark, 2023
Toll-like receptor 3 (TLR3) is a prominent member of the Toll-like receptor (TLR) family and has the ability to recognize and bind intracellular double-stranded RNA (dsRNA).
Bin Han, Chao Zhang, Xiaoxiao Wang, Huangqin Song, Lei Zhang, Tao Li, Jiefeng He, Haoliang Zhao   +7 more
doaj   +1 more source

Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling [PDF]

Science Signaling, 2012
TLR3-mediated antiviral responses require phosphorylation of TLR3 by a growth factor receptor and a nonreceptor tyrosine kinase.
Michifumi, Yamashita, Saurabh, Chattopadhyay, Volker, Fensterl, Paramananda, Saikia, Jaime L, Wetzel, Ganes C, Sen   +5 more
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Evaluation of variants in IL6R, TLR3, and DC-SIGN genes associated with dengue in sampled Colombian population

Biomédica: revista del Instituto Nacional de Salud, 2019
Introduction: Host genetics is recognized as an influential factor for the development of dengue disease. Objective: This study evaluated the association of dengue with the polymorphisms rs8192284 for gene IL6R, rs3775290 for TLR3, and rs7248637 for DC ...
Efren Avendaño-Tamayo, Alex Rúa, María Victoria Parra-Marín, Winston Rojas, Omer Campo, Juan Chacón-Duque, Piedad Agudelo-Flórez, Carlos F. Narváez, Doris M. Salgado, Bertha Nelly Restrepo, Gabriel Bedoya   +10 more
doaj   +1 more source

Role of macrophage-mediated Toll-like receptor 4–interleukin-1R signaling in ectopic tongue pain associated with tooth pulp inflammation

Journal of Neuroinflammation, 2020
Background The existence of referred pain and ectopic paresthesia caused by tooth pulp inflammation may make definitive diagnosis difficult and cause misdiagnosis or mistreatment; thus, elucidation of that molecular mechanism is urgent.
Kohei Kanno, Kohei Shimizu, Masamichi Shinoda, Makoto Hayashi, Osamu Takeichi, Koichi Iwata   +5 more
doaj   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source