Results 1 to 10 of about 618,091 (376)

The Role of Toll Like Receptors in Hematopoietic Malignancies [PDF]

Frontiers in Immunology, 2016
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that shape the innate immune system by identifying pathogen-associated molecular patterns (PAMPS) and host-derived damage associated molecular patterns (DAMPS).
Darlene Monlish, Sima Bhatt, Laura Schuettpelz   +2 more
doaj   +4 more sources

Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma

Journal of Hematology & Oncology, 2021
Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to current therapies and invariably recurs. Despite some advancements in anti-glioma therapies, patients’ prognosis remains poor.
Yang Xun, Hua Yang, Bozena Kaminska, Hua You   +3 more
doaj   +2 more sources

Toll‐like receptors in mammalian sperm [PDF]

Reproductive Medicine and Biology
Background Toll‐like receptors (TLRs) are critical components of the innate immune system and are expressed in various cells, including the reproductive system. Although their roles in female reproductive tissues such as the ovaries and uterus, including
Takashi Umehara, Takahiro Yamanaka, Masayuki Shimada   +2 more
doaj   +2 more sources

Microbiome-gut-brain axis and toll-like receptors in parkinson\u2019s disease [PDF]

International Journal of Molecular Sciences, 2018
Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy, which involves all districts of the brain-gut axis, including the central, autonomic and enteric nervous systems.
Caputi, Valentina, Giron, Maria Cecilia
core   +3 more sources

Toll‐like receptors in health and disease [PDF]

MedComm
Toll‐like receptors (TLRs) are inflammatory triggers and belong to a family of pattern recognition receptors (PRRs) that are central to the regulation of host protective adaptive immune responses. Activation of TLRs in innate immune myeloid cells directs
Kunyu Wang, Hanyao Huang, Qi Zhan, Haoran Ding, Yi Li   +4 more
doaj   +2 more sources

Toll-like receptors in lupus nephritis

Journal of Biomedical Science, 2018
The pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) is based on the loss of self-tolerance against ubiquitous autoantigens involving all mechanisms of adaptive immunity.
Satish Kumar Devarapu, Hans-Joachim Anders   +1 more
doaj   +2 more sources

Toll-like receptors and integrins crosstalk [PDF]

Frontiers in Immunology
Immune system recognizes invading microbes at both pathogen and antigen levels. Toll-like receptors (TLRs) play a key role in the first-line defense against pathogens. Major functions of TLRs include cytokine and chemokine production.
Fahd Alhamdan, Fahd Alhamdan, Fahd Alhamdan, Ganchimeg Bayarsaikhan, Ganchimeg Bayarsaikhan, Ganchimeg Bayarsaikhan, Koichi Yuki, Koichi Yuki, Koichi Yuki   +8 more
doaj   +2 more sources

Brucella infection and Toll-like receptors [PDF]

Frontiers in Cellular and Infection Microbiology
Brucella consists of gram-negative bacteria that have the ability to invade and replicate in professional and non-professional phagocytes, and its prolonged persistence in the host leads to brucellosis, a serious zoonosis.
Hui Yu, Hui Yu, Xinyi Gu, Danfeng Wang, Zhanli Wang   +4 more
doaj   +2 more sources

Toll-like Receptors and Inflammatory Bowel Disease

Frontiers in Immunology, 2018
Inflammatory bowel disease (IBD) is one relapsing and lifelong disease that affects millions of patients worldwide. Increasing evidence has recently highlighted immune-system dysfunction, especially toll-like receptors (TLRs)-mediated innate immune ...
Yue Lu, Xinrui Li, Shanshan Liu, Yifan Zhang, Dekai Zhang, Dekai Zhang   +5 more
doaj   +2 more sources

Role of toll-like receptors in pulmonary immunity: mechanisms and therapeutic implications. [PDF]

Front Immunol
Qu Z, Guo Z, Yang C, Guan X, Cheng M, Wang P, Xu D.   +6 more
europepmc   +2 more sources