Results 1 to 10 of about 608,641 (362)
Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma [PDF]
Journal of Hematology & Oncology, 2021 Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to current therapies and invariably recurs. Despite some advancements in anti-glioma therapies, patients’ prognosis remains poor.
Yang Xun +3 more
semanticscholar +5 more sources
Türk Yoğun Bakim Derneği Dergisi, 2012 Toll-like receptors (TLR) are a class of proteins that play a key role during the first step of interaction between the pathogens and innate immune system.
Aycan Kundakcı, Arash Pirat
doaj +2 more sources
Toll-Like Receptors in Angiogenesis [PDF]
The Scientific World Journal, 2011 Toll-like receptors (TLRs) are known as pattern-recognition receptors related to the Toll protein of Drosophila. After recognition of pathogen-associated molecular patterns of microbial origin, the TLRs alert the immune system, and initiate innate and ...
Karsten Grote +2 more
doaj +4 more sources
Annual Review of Immunology, 2003 The innate immune system in drosophila and mammals senses the invasion of microorganisms using the family of Toll receptors, stimulation of which initiates a range of host defense mechanisms. In drosophila antimicrobial responses rely on two signaling pathways: the Toll pathway and the IMD pathway.
K. Takeda, T. Kaisho, S. Akira
semanticscholar +8 more sources
Toll-like receptors in mammalian sperm. [PDF]
Reprod Med BiolBackground Toll‐like receptors (TLRs) are critical components of the innate immune system and are expressed in various cells, including the reproductive system. Although their roles in female reproductive tissues such as the ovaries and uterus, including
Umehara T, Yamanaka T, Shimada M.
europepmc +2 more sources
Microbes and Infection, 2000 Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria.
Marta Muzio, Alberto Mantovani
openalex +3 more sources
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens [PDF]
Journal of Experimental Medicine, 2001 Toll-like receptors (TLRs) are ancient microbial pattern recognition receptors highly conserved from Drosophila to humans. To investigate if subsets of human dendritic cell precursors (pre-DC), including monocytes (pre-DC1), plasmacytoid DC precursors ...
Norimitsu Kadowaki +6 more
openalex +2 more sources
Toll-like receptors in health and disease. [PDF]
MedComm (2020)Toll‐like receptors (TLRs) are inflammatory triggers and belong to a family of pattern recognition receptors (PRRs) that are central to the regulation of host protective adaptive immune responses. Activation of TLRs in innate immune myeloid cells directs
Wang K, Huang H, Zhan Q, Ding H, Li Y.
europepmc +2 more sources
Toll-like receptors and integrins crosstalk. [PDF]
Front ImmunolImmune system recognizes invading microbes at both pathogen and antigen levels. Toll-like receptors (TLRs) play a key role in the first-line defense against pathogens. Major functions of TLRs include cytokine and chemokine production.
Alhamdan F, Bayarsaikhan G, Yuki K.
europepmc +2 more sources
Brucella infection and Toll-like receptors. [PDF]
Front Cell Infect MicrobiolBrucella consists of gram-negative bacteria that have the ability to invade and replicate in professional and non-professional phagocytes, and its prolonged persistence in the host leads to brucellosis, a serious zoonosis.
Yu H, Gu X, Wang D, Wang Z.
europepmc +2 more sources