Results 11 to 20 of about 196,754 (276)
Toll-Like Receptor Signaling [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Toll-like receptors sense pathogen-associated molecular patterns (e.g., lipopolysaccharides) and trigger gene-expression changes that ultimately eradicate the invading microbes.
Kian-Huat, Lim, Louis M, Staudt
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Intracellular Toll-like Receptors [PDF]
Immunity, 2010 Foreign nucleic acids, the signature of invading viruses and certain bacteria, are sensed intracellularly. The nucleic acid-specific Toll-like receptors (TLRs) detect and signal within endolysosomal compartments, triggering the induction of cytokines essential for the innate immune response.
Blasius, Amanda L., Beutler, Bruce
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Toll like receptors agonists-based nanomedicines as veterinary immunotherapies
Precision Nanomedicine, 2020 Many infections affecting animals enter across mucosa, needing of secretory immunity to reject the disease; protection against some pathogens must be early, fast, and specifically elicited, while from others must be wide enough to fight against ...
Federico L Parra +2 more
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Toll-like receptors in cardiac hypertrophy
Frontiers in Cardiovascular Medicine, 2023 Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that can identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Yanan Zhang +23 more
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Toll-Like Receptor Signaling Pathways [PDF]
Frontiers in Immunology, 2014 Toll-like receptors (TLRs) play crucial roles in the innate immune system by recognizing pathogen-associated molecular patterns derived from various microbes. TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the transcription factors NF-κB and IRFs, which dictate the outcome of innate immune responses.
Kawasaki, Takumi, Kawai, Taro
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Toll-like Receptors in Viral Encephalitis
Viruses, 2021 Viral encephalitis is a rare but serious syndrome. In addition to DNA-encoded herpes viruses, such as herpes simplex virus and varicella zoster virus, RNA-encoded viruses from the families of Flaviviridae, Rhabdoviridae and Paramyxoviridae are important ...
Olivia Luise Gern +6 more
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Journal of the American Society of Nephrology, 2006 Innate and adaptive immunity have traditionally been considered as largely separate though complimentary mechanisms of defense against microbial threats. The adaptive system, being evolutionally newer and having the capacity for selectivity, adaptation, amplification, and memory, has arguably ...
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Japanese Journal of Clinical Immunology, 2005 Toll-like receptors (TLRs) have been revealed to recognize specific patterns of microbial components. Recognition of microbial components by TLRs initiates signal transduction pathways, triggering expression of genes, which products control innate immune responses and further instruct development of antigen-specific acquired immunity.
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Toll-Like Receptors in Angiogenesis
The Scientific World Journal, 2011 Toll-like receptors (TLRs) are known as pattern-recognition receptors related to the Toll protein of Drosophila. After recognition of pathogen-associated molecular patterns of microbial origin, the TLRs alert the immune system, and initiate innate and ...
Karsten Grote +2 more
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The Role of Toll Like Receptors in Hematopoietic Malignancies
Frontiers in Immunology, 2016 Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that shape the innate immune system by identifying pathogen-associated molecular patterns (PAMPS) and host-derived damage associated molecular patterns (DAMPS).
Darlene Monlish +2 more
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