Results 21 to 30 of about 119,102 (41)

Toll-like receptors and NOD-like receptors in rheumatic diseases [PDF]

, 2009
The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury.
McCormack, William J, O'Neill, Luke A, Parker, Andrew E   +2 more
core   +2 more sources

Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
core   +2 more sources

Ibrutinib Unmasks Critical Role of Bruton Tyrosine Kinase in Primary CNS Lymphoma. [PDF]

, 2017
Bruton tyrosine kinase (BTK) links the B-cell antigen receptor (BCR) and Toll-like receptors with NF-κB. The role of BTK in primary central nervous system (CNS) lymphoma (PCNSL) is unknown.
Brennan, Cameron W., Campos, Carl, Clark, Owen, Codega, Paolo, DeAngelis, Lisa M., Dogan, Ahmet, Gavrilovic, Igor T., Glass, Jon, Graeber, Thomas G., Grommes, Christian, Gutin, Philip H., Hamlin, Paul, Hatzoglou, Vaios, Hsieh, Wan-Ying, Huse, Jason T., Kaley, Thomas J., Lallana, Enrico C., Mellinghoff, Ingo K., Moskowitz, Craig H., Nichol, Donna, Nolan, Craig P., Noy, Ariela, Omuro, Antonio, Palaskas, Nicolaos, Palomba, M. Lia, Panageas, Katherine S., Pastore, Alessandro, Peak, Scott, Pentsova, Elena, Reiner, Anne S., Rohle, Dan, Rosenblum, Marc, Sauter, Craig S., Schartz, Derrek, Schultz, Nikolaus, Tabar, Viviane S., Tang, Sarah S., Thomas, Alissa A., Tsyvkin, Elina, Viale, Agnes, Wolfe, Julia, Won, Minhee   +41 more
core   +2 more sources

Nous aliats contra la Tuberculosi [PDF]

, 2007
En el segle XXI la tuberculosi continua sent causa d'un important nombre de defuncions cada any. Existeixen vacunes, però la eficàcia que ofereixen no es molt elevada.
Julián Gómez, Esther
core   +1 more source

Lung cancer and Toll-like receptors. [PDF]

, 2011
Lung carcinoma is one of the leading causes of death worldwide. It is a non-immunogenic cancer, resistant to immune surveillance. Toll-like receptors (TLRs) connect the innate to the adaptive immune system.
MORELLO, SILVANA, PINTO, Aldo, SORRENTINO, ROSALINDA   +2 more
core   +1 more source

Lack of an Antibacterial Response Defect in Drosophila Toll-9 Mutant [PDF]

, 2011
Toll and Toll-like receptors represent families of receptors involved in mediating innate immunity response in insects and mammals. Although Drosophila proteome contains multiple Toll paralogs, Toll-1 is, so far, the only receptor to which an immune role
A Bergmann, A Defaye, A Dev, A Poltorak, A Rolls, A Seppo, AN Weber, Andreas Bergmann, B Beutler, B Charroux, B Charroux, B Lemaitre, B Lemaitre, B Lemaitre, B Ohlstein, Bernard Charroux, C Hashimoto, C Hetru, C Luo, CA Micchelli, D Rose, DS Schneider, E De Gregorio, E De Gregorio, E Eldon, E Okun, EM Ha, F Leulier, GM Rubin, H Bilak, H Sun, J Royet, JA Hoffmann, JH Ryu, JH Ryu, JL Imler, JL Ramirez, JS Cameron, Julien Royet, JY Ooi, K Hoshino, Karine Narbonne-Reveau, KP Rehorn, KV Anderson, M Gangloff, MA Armant, MC Moncrieffe, MS Halfon, MS Halfon, N Buchon, N Buchon, N Buchon, N Lhocine, NJ Gay, NQ Fernandez, P Irving, P Tzou, R Bettencourt, R Shechter, S Kim, S Pal, S Tauszig, S Tauszig-Delamasure, S Wu, SM Kanzok, T Kawai, T Kawai, T Lebestky, T Michel, W Wood, X Du, Y Ma, Y Yagi, YS Rong, Z Kambris   +74 more
core   +3 more sources

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

Gastrointestinal neuromuscular apparatus: An underestimated target of gut microbiota [PDF]

, 2016
Over the last few years, the importance of the resident intestinal microbiota in the pathogenesis of several gastro- intestinal diseases has been largely investigated.
Cicala, M, Guarino, Mp, Putignani, L, Severi, Carola   +3 more
core   +1 more source

The Efficacy of Two Specific Toll-Like Receptor 4 Antagonists (G2013 & M2000) In Clinical Inflammatory Disease [PDF]

, 2023
Toll-like receptors (TLRs) are receptors of the innate immune system that detect pathogen- associated molecular patterns and endogenous “danger” molecules. Among the family, the fundamental role of Toll-like receptor 4 (TLR 4) has been underscored in the
Mirshafiey, Abbas, Rahmani, Mehdi, Sharifi, Laleh, Taeb, Mahsa   +3 more
core   +1 more source

Toll-Like Receptors in Wound Healing: Location, Accessibility, and Timing [PDF]

, 2012
Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process ...
Dasu, Mohan R., Rivkah Isseroff, R.
core   +1 more source