Results 81 to 90 of about 12,937,378 (338)

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Molecules, 2021
The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses.
Leander Geske, Ulrich Kauhl, Mohamed E. M. Saeed, Anja Schüffler, Eckhard Thines, Thomas Efferth, Till Opatz   +6 more
doaj   +1 more source

Total synthesis of aurofusarin: studies on the atropisomeric stability of bis-naphthoquinones [PDF]

, 2018
An efficient annulation involving pyrone addition to a quinone and Dieckmann condensation was developed for rapid assembly of a γ-naphthopyrone monomeric precursor to the bis-naphthoquinone natural product aurofusarin.
Allen, Ashley, Bao, Berkessel, Birchall, Bringmann, Bringmann, Chen, Corey, Crimmins, Dao, Donner, Dwyer, Flegel, Frandsen, Gao, Gray, Helder, Jew, Konkol, Lee, Leeper, Liau, Masson, Morishita, Natori, Romaine, Shi, Shibata, Shibata, Shibata, Shirakawa, Shirakawa, Sperry, Sun, Takeya, Takizawa, Varun, Wu, Yeung, Zeeck, Zhang, Ōki   +42 more
core   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Recent Advances on Biological Activities and Structural Modifications of Dehydroabietic Acid

Toxins, 2022
Dehydroabietic acid is a tricyclic diterpenoid resin acid isolated from rosin. Dehydroabietic acid and its derivatives showed lots of medical and agricultural bioactivities, such as anticancer, antibacterial, antiviral, antiulcer, insecticidal, and ...
Meng Hao, Jianwei Xu, Houpeng Wen, Jiawei Du, Shaoyong Zhang, Min Lv, Hui Xu   +6 more
doaj   +1 more source

Total Synthesis of Rapamycin

Angewandte Chemie International Edition, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Maddess, M, Tackett, M, Watanabe, H, Brennan, P, Spilling, C, Scott, J, Osborn, D, Ley, S   +7 more
openaire   +5 more sources

Total Synthesis of (.+‐.)‐Hasubanonine. [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Liwen He, Spencer B. Jones, Steven L. Castle   +2 more
openaire   +4 more sources

Synthesis of the isoquinoline alkaloid, crispine C [PDF]

, 2012
The first total synthesis of the isoquinoline alkaloid, crispine C is described in seven steps using a Henry reaction and the Pictet–Gams variant of the Bischler–Napieralski reaction to effect the key ...
Adele Blair, Ahluwalia, Allin, Amat, Andrew Sutherland, Bailey, Barker, Bernatowicz, Bernatowicz, Bernstein, Bischler, Bischoff, Blankespoor, Chiou, Coldham, Czarnocki, Dobrowsky, Dyke, Forrö, Gurram, Guénin, Hamilton, Hou, Kanemitsu, Kawai, King, Knolker, Louafi, Louise Stevenson, Luzzio, Meyer, Miyazaki, Ott, Pictet, Prudhommeaux, Reid, Saha, Szawkalo, Walker, Yasuhara, Yioti, Zaed, Zhang   +42 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Total Synthesis of a Marine Alkaloid—Rigidin E

Marine Drugs, 2012
In the present paper, we report an efficient total synthesis of a marine alkaloid, rigidin E. The key tetrasubstituted 2-amino-3-carboxamidepyrrole intermediate was synthesized by cascade Michael addition/intramolecular cyclization between <em>N<
Qiang Xiao, Xiaoji Wang, Ruchun Yang, Haixin Ding, Banpeng Cao   +4 more
doaj   +1 more source