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Maladaptive trained immunity in viral infections [PDF]
The Journal of Clinical InvestigationTrained immunity (TRIM) is a form of long-lasting functional reprogramming of innate immune cells and their progenitors that enhances responsiveness to subsequent stimuli.
Dmitri Sviridov +2 more
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Trained immunity in the lung [PDF]
eLifeTrained immunity represents a recent concept that elucidates the long-term reprogramming of innate immune cells, enabling them to adapt and respond more effectively to subsequent encounters with diverse pathogens.
Elina Idiiatullina, Dane Parker
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Evolving our understanding of trained immunity [PDF]
eLifeThe articles in this focus issue discuss progress towards a more complete understanding of memory in the innate immune system, and efforts to exploit “trained immunity” for the development of new vaccines and therapeutics.
Eva Kaufmann +5 more
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Trained immunity in farm animals [PDF]
Veterinary ResearchThe mechanisms that enable the innate defence system to “remember its enemies” have opened a new field in immunology, and the evolutionary links among the various defence mechanisms are now being uncovered.
Marisol Báez-Magaña +3 more
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Trained Immunity in Health and Disease [PDF]
MedCommTrained immunity as a critical regulator of host defense and disease pathogenesis bridges the gap between innate and adaptive immunity. For decades, the classic dichotomy of innate immunity and adaptive immunity has shaped our knowledge of immune ...
Meng Yao +8 more
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The significance of trained immunity in cancer [PDF]
Frontiers in ImmunologyTrained immunity (TI) represented a unique state of innate immune activation, characterized primarily by persistent epigenetic modifications in immune cells.
Junxing Qu +10 more
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The double-edged nature of trained immunity [PDF]
eLifeTrained immunity in alveolar macrophages can lead to damaging lung inflammation, confirming the importance of context in this phenomenon.
Chrissy M Leopold Wager +1 more
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Western lifestyle linked to maladaptive trained immunity [PDF]
eLifeTrained immunity (TI) refers to a state of innate immune cells that, after encountering an initial stimulus and undergoing epigenetic reprogramming and metabolic changes, allows them to respond more effectively to a subsequent challenge.
Aurelia Josephine Merbecks +5 more
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Interleukin-38 is a negative regulator of trained immunity—A retrospective multi-omics study [PDF]
iScienceSummary: Trained immunity is a long-lasting innate immune cell phenotype with benefits in infection control and recognized anti-cancer effects. Conversely, inappropriately induced trained immunity contributes to pathological inflammation, warranting the ...
Lisa U. Teufel +12 more
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Trained immunity: A new player in cancer immunotherapy [PDF]
eLifeIn the past, immune memory was considered an exclusive feature of the adaptive immune system. However, accumulating evidence suggests that the innate immune system, the most primitive and fundamental component of immunity, can mount more robust responses
Shu Li +4 more
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