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Probiotics and Trained Immunity
The characteristics of innate immunity have recently been investigated in depth in several research articles, and original findings suggest that innate immunity also has a memory capacity, which has been named “trained immunity”.
Naima G. Cortes-Perez +4 more
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Trained Immunity and HIV Infection
Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for many years. Recently, underlying mechanisms of this phenomenon have started to come to light.
Dmitri Sviridov +3 more
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Trained Immunity Carried by Non-immune Cells [PDF]
“Trained immunity” is a term proposed by Netea to describe the ability of an organism to develop an exacerbated immunological response to protect against a second infection independent of the adaptative immunity. This immunological memory can last from 1
Attoumani Hamada +3 more
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Trained immunity: A Yin‐Yang balance
Traditionally, immune memory is regarded as an exclusive hallmark of adaptive immunity. However, a growing body of evidence suggesting that innate immune cells show adaptive characteristics has challenged this dogma. In the past decade, trained immunity,
Zhidong Hu +3 more
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‘Trained immunity’: consequences for lymphoid malignancies [PDF]
In hematological malignancies complex interactions exist between the immune system, microorganisms and malignant cells. On one hand, microorganisms can induce cancer, as illustrated by specific infection-induced lymphoproliferative diseases such as ...
Wendy B.C. Stevens +3 more
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Editorial: Trained Immunity-Based Vaccines [PDF]
Jose Luis Subiza +3 more
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Trained immunity inducers in cancer immunotherapy
While most of the cancer immunotherapy strategies engage adaptive immunity, especially tumor-associated T cells, the small fraction of responding patients and types of cancers amenable, and the possibility of severe adverse effects limit its usage.
Yongjun Sui, Jay A. Berzofsky
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Adaptive immune responses are characterized by antigen specificity and induction of lifelong immunologic memory. Recently, it has been reported that innate immune cells can also build immune memory characteristics—a process termed trained immunity. Trained immunity describes the persistent hyperresponsive phenotype that innate immune cells can develop ...
Tercan, H. +6 more
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From trained immunity in allergy to trained
AbstractInnate immune cells experience long lasting metabolic and epigenetic changes after an encounter with specific stimuli. This facilitates enhanced immune responses upon secondary exposition to both the same and unrelated pathogens, a process termed trained immunity.
Leticia Martín‐Cruz +6 more
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Effector-Triggered Trained Immunity: An Innate Immune Memory to Microbial Virulence Factors?
In the last decade, a major dogma in the field of immunology has been called into question by the identification of a cell autonomous innate immune memory.
Cedric Torre, Laurent Boyer
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