Results 21 to 30 of about 61,594 (230)

Trained Immunity Exacerbates Inflammatory Arthritis Progression via Promoting Synovial Fibroblast Ferroptotic Resistance [PDF]

Advanced Science
Trained immunity induced by β‐glucan insult drives the functional reprogramming of macrophages to the hyperinflammatory status, contributing to developing or maintaining inflammatory diseases.
Haibo Su, Baoying Zhang, Qiudi Deng, Jiaxin Huang, Jinyu Feng, Yuan Fu, Yuejun Huang, Weikun Deng, YingJun Su, Huisheng Liu, Ning‐yi Shao, Zhenhui Zhang, Jianwei Dai   +12 more
doaj   +2 more sources

Trained immunity: implications for vaccination [PDF]

Current Opinion in Immunology, 2022
The concept that only adaptive immunity can build immunological memory has been challenged in the past decade. Live attenuated vaccines such as the Bacillus Calmette-Guérin, measles-containing vaccines, and the oral polio vaccine have been shown to reduce overall mortality beyond their effects attributable to the targeted diseases.
Geckin, Büsranur, Konstantin Föhse, Friedrich, Domínguez-Andrés, Jorge, Netea, Mihai G   +3 more
openaire   +2 more sources

Epigenetics and Trained Immunity [PDF]

Antioxidants & Redox Signaling, 2018
A growing body of clinical and experimental evidence has challenged the traditional understanding that only the adaptive immune system can mount immunological memory. Recent findings describe the adaptive characteristics of the innate immune system, underscored by its ability to remember antecedent foreign encounters and respond in a nonspecific ...
van der Heijden, C.D.C.C., Noz, M.P., Joosten, L.A.B., Joosten, L.A.B., Netea, M.G., Netea, M.G., Riksen, N.P., Keating, S.T.   +7 more
openaire   +4 more sources

Trained immunity: adaptation within innate immune mechanisms

Physiological Reviews, 2023
The mechanisms underlying innate immune memory have been extensively explored in the last decades but are in fact largely unknown. Although the specificity of adaptive immune memory in vertebrates is ensured through the recombination of immunoglobulin family genes and clonal expansion, the basic mechanisms of innate immune cells’ nonspecific increased
Domínguez-Andrés, Jorge, dos Santos, Jéssica Cristina, Bekkering, Siroon, Mulder, Willem J. M., van der Meer, Jos W. M., Riksen, Niels P., Joosten, Leo A. B., Netea, Mihai G.   +7 more
openaire   +3 more sources

Trained immunity in type 2 immune responses

Mucosal Immunology, 2022
Immunological memory of innate immune cells, also termed "trained immunity", allows for cross-protection against distinct pathogens, but may also drive chronic inflammation. Recent studies have shown that memory responses associated with type 2 immunity do not solely rely on adaptive immune cells, such as T- and B cells, but also involve the innate ...
Hartung, F., Esser-von Bieren, J.
openaire   +4 more sources

BCG-Induced Immune Training: Interplay between Trained Immunity and Emergency Granulopoiesis

Journal of Molecular Biology, 2023
Bacille Calmette-Guérin (BCG) is the most commonly administered vaccine in human history. The medical application of BCG extends far beyond the fight against tuberculosis. Despite its stellar medical record over 100 years, insight into how BCG provides this vast range of benefits is largely limited, both for its pathogen-specific (tuberculosis) as well
Andualem, Henok, Hollams, Elysia, Kollmann, Tobias R., Amenyogbe, Nelly   +3 more
openaire   +2 more sources

β-Glucan Induces Training Immunity to Promote Antiviral Activity by Activating TBK1

Viruses, 2023
Many studies have shown that β-glucan induces a trained immune phenotype in innate immune cells to defend against bacterial and fungal infections. The specific mechanism involves cellular metabolism and epigenetic reprogramming.
Guolei Wang, Zhiqiang Li, Mingfu Tian, Xianghua Cui, Jun’e Ma, Siyu Liu, Chenglin Ye, Li Yuan, Muhammad Suhaib Qudus, Uzair Afaq, Kailang Wu, Xinghui Liu, Chengliang Zhu   +12 more
doaj   +1 more source

Trained immunity

Cell Host and Microbe, 2023
Trained immunity is a de facto memory for innate immune responses, leading to long-term functional reprogramming of innate immune cells. In physiological conditions, trained immunity leads to adaptive states that enhance resistance against pathogens and contributes to immunosurveillance.
Ziogas, Athanasios, Bruno, Mariolina, van der Meel, Roy, Mulder, Willem J.M., Netea, Mihai G.   +4 more
openaire   +1 more source

Trained innate immunity and atherosclerosis [PDF]

Current Opinion in Lipidology, 2013
Monocytes/macrophages play a decisive role in the development and progression of atherosclerosis. It is currently unknown what stimuli initiate and orchestrate the activation of these cells in atherogenesis. In this review, we postulate that the novel concept of 'trained immunity' modulates the development and progression of atherosclerosis.Recently ...
Bekkering, S., Joosten, L.A.B., van der Meer, J.W.M., Netea, M.G., Riksen, N.P., Riksen, N.P.   +5 more
openaire   +3 more sources

DAMPs and Innate Immune Training [PDF]

Frontiers in Immunology, 2021
The ability to remember a previous encounter with pathogens was long thought to be a key feature of the adaptive immune system enabling the host to mount a faster, more specific and more effective immune response upon the reencounter, reducing the severity of infectious diseases.
Elisa Jentho, Elisa Jentho, Sebastian Weis, Sebastian Weis   +3 more
openaire   +3 more sources