Results 51 to 60 of about 3,486,426 (236)

A shared cis-regulatory module activates transcription in the suspensor of plant embryos. [PDF]

, 2018
The mechanisms controlling the transcription of gene sets in specific regions of a plant embryo shortly after fertilization remain unknown. Previously, we showed that G564 mRNA, encoding a protein of unknown function, accumulates to high levels in the ...
Bui, Anhthu Q, Goldberg, Robert B, Henry, Kelli F, Kawashima, Tomokazu   +3 more
core  

Transcription elongation [PDF]

Transcription, 2017
This review is focused on recent progress in understanding how Escherichia coli RNAP polymerase translocates along the DNA template and the factors that affect this movement. We discuss the fundamental aspects of RNAP translocation, template signals that influence forward or backward movement, and host or phage factors that modulate translocation.
Arkady, Mustaev, Jeffrey, Roberts, Max, Gottesman   +2 more
openaire   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A novel compartment, the 'subqpical stem' of the aerial hyphae, is the location of a sigN-dependent, developmentally distinct transcription in Streptomyces coelicolor. [PDF]

, 2007
Streptomyces coelicolor has nine SigB-like RNA polymerase sigma factors, several of them implicated in morphological differentiation and/or responses to different stresses. One of the nine, SigN, is the focus of this article.
Bignell D.R., Boylan S.A., Champness W.C., Delic V., Errington J., Flardh K., Haldenwang W.G., Homerova D., Hopwood D.A., Kalman S., Karmazyn-Campelli C., Kelemen G.H., Kieser T., Lee E.J., Masuda E.S., Mendez C., Merrick M.J., Nodwell J.R., Price C.W., Sun J., Wildermuth H., Willey J.   +21 more
core   +1 more source

Transcriptional networking.

, 2005
A report on the European Science Foundation workshop 'Transcription Networks: A Global View', Madrid, Spain, 26-28 May 2005.
Teichmann, Sarah A, Bornberg-Bauer, Erich, Luscombe, Nicholas M   +2 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Transcriptional enhancers: Transcription, function and flexibility [PDF]

Transcription, 2016
Active transcriptional enhancers are often transcribed to eRNAs, whose changing levels mirror those of the target gene mRNA. We discuss some of the reported functions of these eRNAs and their likely diversity to allow utilization of distinct cis regulatory regions to enhance transcription in diverse developmental and cellular contexts.
Philippa, Melamed, Yahav, Yosefzon, Sergei, Rudnizky, Lilach, Pnueli   +3 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Transcription of the sporulation gene ssgA is activated by the IcIR-type regulator SsgR in a whi-independent manner in Streptomyces coelicolor A3(2). [PDF]

, 2004
SsgA plays an important role in the control of sporulation-specific cell division and morphogenesis of streptomycetes, and ssgA null mutants have a rare conditionally non-sporulating phenotype.
Bentley, Bierman, Chater, Chater, Chater, Chater, Chater, Embley, Flärdh, Flärdh, Flärdh, Galinier, Higgins, Hindle, Horinouchi, Ikeda, Ishikawa, Janssen, Jiang, Kawamoto, Kawamoto, Keijser, Kelemen, Kieser, Larson, Lydiate, MacNeil, Ohnishi, Pan, Ryding, Sambrook, Soliveri, Strohl, Sunnarborg, Takano, Takano, Van Wezel, Van Wezel, Van Wezel, Vara, Yamamoto, Yamazaki, Zhang   +42 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source