Results 71 to 80 of about 736,695 (298)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Genome-wide discovery of small RNAs in Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2012
Only few small RNAs (sRNAs) have been characterized in Mycobacterium tuberculosis and their role in regulatory networks is still poorly understood. Here we report a genome-wide characterization of sRNAs in M.
Paolo Miotto, Francesca Forti, Alessandro Ambrosi, Danilo Pellin, Diogo F Veiga, Gabor Balazsi, Maria L Gennaro, Clelia Di Serio, Daniela Ghisotti, Daniela M Cirillo   +9 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Dynamic analysis of stochastic transcription cycles [PDF]

, 2011
In individual mammalian cells the expression of some genes such as prolactin is highly variable over time and has been suggested to occur in stochastic pulses.
Davis, Julian R. E., Harper, Claire V., White, Michael R H, Mullins John J., Finkenstädt Bärbel, Davis, Julian R E, See Profile, Mullins, John J, Semprini Sabrina, John J Mullins, Harper Claire V., Sabrina Semprini, Davis Julian R. E., Finkenstaedt, Baerbel, Michael R H White, Friedrichsen, Soenke, Woodcock, Dan J., Spiller, David G., Rand, David A., Mullins, John J., Harper, Claire V; id_orcid, Spiller, David G.; id_orcid, Bärbel Finkenstädt, Woodcock Dan J., Julian R. E. Davis, Woodcock, Dan J, Spiller, David G, David A Rand, Friedrichsen Sönke, Julian R E Davis, David G. Spiller, Michael R. H. White, Ashall Louise, David A. Rand, Friedrichsen, Sönke, John J. Mullins, Dan J. Woodcock, Rand, D. A. (David A.), Spiller David G., White Michael R. H., White, Michael R. H., Louise Ashall, Sönke Friedrichsen, Semprini, Sabrina, Ashall, Louise, Rand, David A, David G Spiller, David A. R, Finkenstädt, Bärbel, Dan J Woodcock, Rand David A., Claire V. Harper, Claire V Harper   +52 more
core   +1 more source

Modeling RNA polymerase interaction in mitochondria of chordates

Biology Direct, 2012
Background In previous work, we introduced a concept, a mathematical model and its computer realization that describe the interaction between bacterial and phage type RNA polymerases, protein factors, DNA and RNA secondary structures during transcription,
Lyubetsky Vassily A, Zverkov Oleg A, Pirogov Sergey A, Rubanov Lev I, Seliverstov Alexandr V   +4 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A bacterial transcription terminator with inefficient molecular motor action but with a robust transcription termination function

, 2010
Molecular motors such as helicases/translocases are capable of translocating along the single-stranded nucleic acids and unwinding DNA or RNA duplex substrates using the energy derived from their ATPase activity.
Kalarickal, Nisha C., Sen, Ranjan, Kalyani, B. Sudha, Ranjan, Amitabh, Wal, Megha   +4 more
core   +1 more source

Analysis of RNA Transcribed by RNA Polymerase III from B2 SINEs in Mouse Cells

Non-Coding RNA
Background/Objectives: SINEs (short interspersed elements) are eukaryotic non-autonomous retrotransposons. They are transcribed by RNA polymerase III (pol III) and generate non-coding RNAs.
Olga R. Borodulina, Sergey A. Kosushkin, Ilia G. Ustyantsev, Nikita S. Vassetzky, Dmitri A. Kramerov   +4 more
doaj   +1 more source

Genetic circuit characterization and debugging using RNA‐seq

Molecular Systems Biology, 2017
Genetic circuits implement computational operations within a cell. Debugging them is difficult because their function is defined by multiple states (e.g., combinations of inputs) that vary in time.
Thomas E Gorochowski, Amin Espah Borujeni, Yongjin Park, Alec AK Nielsen, Jing Zhang, Bryan S Der, D Benjamin Gordon, Christopher A Voigt   +7 more
doaj   +1 more source

Termination of the ovalbumin gene transcription.

The EMBO Journal, 1984
RNA transcribed in vivo from the chicken ovalbumin gene has been analyzed in detail in the 3' region of the gene using nuclease S1 mapping and Northern blotting. We describe two new additional minor polyadenylation sites leading to pre-messenger RNA with lengths of approximately 7900 and 9700 nucleotides.
LeMeur, M.a., Galliot, Brigitte, Gerlinger, P.   +2 more
openaire   +2 more sources