Results 51 to 60 of about 345,542 (371)
Annals of the Rheumatic Diseases, 2022 Objective Genome-wide association studies (GWAS) have identified >100 risk loci for systemic lupus erythematosus (SLE), but the disease genes at most loci remain unclear, hampering translation of these genetic discoveries.
X. Yin +80 more
semanticscholar +1 more source
Integrative approaches for large-scale transcriptome-wide association studies [PDF]
Nature Genetics, 2015 AbstractMany genetic variants influence complex traits by modulating gene expression, thus altering the abundance levels of one or multiple proteins. In this work we introduce a powerful strategy that integrates gene expression measurements with large-scale genome-wide association data to identify genes whose cis-regulated expression is associated to ...
Alexander Gusev +24 more
openaire +9 more sources
Identification of genes associated with testicular germ cell tumor susceptibility through a transcriptome-wide association study. [PDF]
Am J Hum GenetUgalde-Morales E +49 more
europepmc +2 more sources
Multi-omics integration reveals molecular networks and regulators of psoriasis. [PDF]
, 2019 BackgroundPsoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic ...
Arneson, Douglas +5 more
core +3 more sources
A transcriptome-wide association study identifies susceptibility genes for Parkinson’s disease
npj Parkinson's Disease, 2021 Genome-wide association study (GWAS) has seen great strides in revealing initial insights into the genetic architecture of Parkinson’s disease (PD). Since GWAS signals often reside in non-coding regions, relatively few of the associations have implicated
S. Yao +9 more
semanticscholar +1 more source
Frontiers in Genetics, 2022 Objective: We identify and explore the candidate susceptibility genes for cirrhosis and their underlying biological mechanism.Methods: We downloaded the genome-wide association studies summary data of 901 cirrhosis cases and 451,363 controls and ...
Xiao-Bo Zhu +7 more
doaj +1 more source
Simultaneous profiling of transcriptome and DNA methylome from a single cell. [PDF]
, 2016 BackgroundSingle-cell transcriptome and single-cell methylome technologies have become powerful tools to study RNA and DNA methylation profiles of single cells at a genome-wide scale. A major challenge has been to understand the direct correlation of DNA
An, Qin +9 more
core +3 more sources
2D association and integrative omics analysis in rice provides systems biology view in trait analysis. [PDF]
, 2018 The interactions among genes and between genes and environment contribute significantly to the phenotypic variation of complex traits and may be possible explanations for missing heritability.
Dai, Xinbin +3 more
core +2 more sources
Transcriptome-wide association studies accounting for colocalization using Egger regression [PDF]
Genetic Epidemiology, 2017 AbstractIntegrating genome-wide association (GWAS) and expression quantitative trait locus (eQTL) data into transcriptome-wide association studies (TWAS) based on predicted expression can boost power to detect novel disease loci or pinpoint the susceptibility gene at a known disease locus.
Richard Barfield +6 more
openaire +3 more sources
Frontiers in Genetics, 2021 BackgroundAcute myocardial infarction (AMI), characterized by an event of myocardial necrosis, is a common cardiac emergency worldwide. However, the genetic mechanisms of AMI remain largely elusive.MethodsA genome-wide association study dataset of AMI ...
Guanzhong Chen +22 more
doaj +1 more source