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The Alterations in and the Role of the Th17/Treg Balance in Metabolic Diseases
Frontiers in Immunology, 2021 Chronic inflammation plays an important role in the development of metabolic diseases. These include obesity, type 2 diabetes mellitus, and metabolic dysfunction-associated fatty liver disease.
Siwen Zhang +6 more
semanticscholar +1 more source
A Bacterial Bile Acid Metabolite Modulates Treg Activity through the Nuclear Hormone Receptor NR4A1
bioRxiv, 2021 Bile acids act as signaling molecules that regulate immune homeostasis, including the differentiation of CD4+ T cells into distinct T cell subsets.
Wei Li +12 more
semanticscholar +1 more source
Once a Treg, always a Treg? [PDF]
Immunological Reviews, 2014 SummaryRegulatory T cells (Tregs) prevail as a specialized cell lineage that has a central role in the dominant control of immunological tolerance and maintenance of immune homeostasis. Thymus‐derived Tregs (tTregs) and their peripherally induced counterparts (pTregs) are imprinted with unique Forkhead box protein 3 (Foxp3)‐dependent and independent ...
Deepali V, Sawant, Dario A A, Vignali
openaire +2 more sources
CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications
Biomedicines, 2022 Regulatory T cells are critical for maintaining immune tolerance. Recent studies have confirmed their therapeutic suppressive potential to modulate immune responses in organ transplant and autoimmune diseases. However, the unknown and nonspecific antigen
M. Arjomandnejad +2 more
semanticscholar +1 more source
Pathological conditions re-shape physiological Tregs into pathological Tregs [PDF]
Burns & Trauma, 2015 AbstractCD4+FOXP3+ regulatory T cells (Tregs) are a subset of CD4 T cells that play an essential role in maintaining peripheral immune tolerance, controlling acute and chronic inflammation, allergy, autoimmune diseases, and anti-cancer immune responses. Over the past 20 years, a significant progress has been made since Tregs were first characterized in
Yang, William Y +5 more
openaire +2 more sources
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo [PDF]
, 2015 Objective: Gut homing of lymphocytes via adhesion molecules has recently emerged as new target for therapy in inflammatory bowel diseases. We aimed to analyze the in vivo homing of effector (Teff) and regulatory (Treg) T cells to the inflamed gut via ...
Agace +64 more
core +1 more source
Bile acid metabolites control Th17 and Treg cell differentiation
bioRxiv, 2018 Bile acids are abundant in the mammalian gut, where they undergo bacteria-mediated transformation to generate a large pool of bioactive molecules. Although bile acids are known to affect host metabolism, cancer progression and innate immunity, it is ...
Saiyu Hang +19 more
semanticscholar +2 more sources
The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes
JCI Insight, 2021 BACKGROUND A previous phase I study showed that the infusion of autologous Tregs expanded ex vivo into patients with recent-onset type 1 diabetes (T1D) had an excellent safety profile.
S. Dong +19 more
semanticscholar +1 more source
Immune monitoring of the body’s borders
AIMS Allergy and Immunology, 2018 The immune system spends most of its efforts and energy policing rather than attacking, cleaning up the molecular and cellular trash, maintaining the borders of the human body, and quashing minor disturbances rather than responding to pathogenic microbes.
Ken S. Rosenthal
doaj +1 more source
Nature Communications, 2021 Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma (GBM) trials. Here, we show that regulatory T (Treg) cells play a key role in GBM resistance to ICBs in experimental gliomas.
Zohreh Amoozgar +21 more
semanticscholar +1 more source