Results 41 to 50 of about 275,584 (397)
MicroRNAs regulate T-cell production of interleukin-9 and identify hypoxia-inducible factor-2a as an important regulator of T helper 9 and regularoty T-cell differentiation [PDF]
, 2016 MicroRNAs (miRNAs) regulate many aspects of helper T cell (Th) development and function. Here we found that they are required for the suppression of interleukin‐9 (IL‐9) expression in Th9 cells and other Th subsets. Two highly related miRNAs (miR‐15b and
Baumjohann +37 more
core +2 more sources
Treg Heterogeneity, Function, and Homeostasis
Frontiers in Immunology, 2020 T-regulatory cells (Tregs) represent a unique subpopulation of helper T-cells by maintaining immune equilibrium using various mechanisms. The role of T-cell receptors (TCR) in providing homeostasis and activation of conventional T-cells is well-known ...
D. Shevyrev, V. Tereshchenko
semanticscholar +1 more source
Педиатрическая фармакология, 2013 The study presents the review of recent literature on microbial resistance in children suffered from reccurent respiratory infaction (RRI). Special aspects of immune system in children with allergy and acute respiratory infection are discussed. We report
A. D. Pertseva +4 more
doaj +1 more source
Autoimmunity, 2023 Sepsis-induced acute respiratory distress syndrome (ARDS) remains a major complication of death from bacterial infection. Regulatory T cells (Tregs) are important regulators in addressing lung injury.
Jian Zhong +5 more
doaj +1 more source
IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]
, 2019 An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Burmester, Gerd-Rüdiger +8 more
core +2 more sources
Frontiers in Immunology, 2021 Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with gut microbiota disequilibrium and regulatory T (Treg)/T helper 17 (Th17) immune imbalance. Stigmasterol, a plant-derived sterol, has shown anti-inflammatory effects. Our study aimed
Shuting Wen +6 more
semanticscholar +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
core +2 more sources
Review – Helicobacter: inflammation, immunity and vaccines [PDF]
Microbiota in Health and Disease, 2021 Helicobacter pylori is a bacterium that colonizes the human stomach and is the risk factor for severe gastroduodenal diseases, such as gastric cancer, gastric lymphoma, autoimmune gastritis and peptic ulcer. H.
M. D’Elios, M. de Bernard
doaj +1 more source
Profound Treg perturbations correlate with COVID-19 severity
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Regulatory T cells (Tregs) are responsible for restraining excessive inflammation, a hallmark of COVID-19. We identified a striking phenotype in Tregs from patients with severe disease, as well as an interesting role for interleukin (IL)-6 ...
Silvia Galván-Peña +17 more
semanticscholar +1 more source
Oncotarget, 2015 FOXP3 positive regulatory T cells (Tregs) are key players in maintaining peripheral immune tolerance. Multiple molecules and signaling pathways are involved in regulating Treg function. Understanding these mechanisms is vital to designing Treg-targeted immunotherapeutic strategies for cancer and other diseases. A recent study uncovered that endoplasmic
Yongliang, Zhang +2 more
openaire +2 more sources