Results 41 to 50 of about 212,475 (307)

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

OncoImmunology, 2019
Purpose: Local tumor ablation through irreversible electroporation (IRE) may offer a novel therapeutic option for locally advanced pancreatic cancer (LAPC). It may also serve as a means of in vivo vaccination.
Hester J. Scheffer, Anita G.M. Stam, Bart Geboers, Laurien G.P.H. Vroomen, Alette Ruarus, Beaunelle de Bruijn, M. Petrousjka van den Tol, Geert Kazemier, Martijn R. Meijerink, Tanja D. de Gruijl   +9 more
doaj   +1 more source

Upregulation of Cytokines and Differentiation of Th17 and Treg by Dendritic Cells: Central Role of Prostaglandin E2 Induced by Mycobacterium bovis

Microorganisms, 2020
Mycobacterium bovis (M. bovis) is a zoonotic pathogen that causes bovine and human tuberculosis. Dendritic cells play a critical role in initiating and regulating immune responses by promoting antigen-specific T-cell activation.
Han Liu, Xuekai Xiong, Wenjun Zhai, Tingting Zhu, Xiaojie Zhu, Yifan Zhu, Yongchong Peng, Yongliang Zhang, Jieru Wang, Huanchun Chen, Yingyu Chen, Aizhen Guo   +11 more
doaj   +1 more source

Frequency of CD39+, LAG3+, and CTLA4+ Regulatory T Cells in Two Different Immunosuppressive Protocols in Renal Allograft Recipients (Sirolimus vs Mycophenolate mofetil): A Cohort Report [PDF]

Iranian Journal of Immunology, 2022
Background: Impaired renal function is considered as a significant risk factor for cardiovascular events in chronic kidney disease patients. Several immunosuppressive drugs are used in these patients, which necessitates to minimize the drug-related side ...
Yaghoub Mollaei-Kandelous, Pedram Ahmadpoor, Mohsen Nafar, Mohammad Reza Khatami, Samad Farashi Bonab, Nader Tajik, Mahdi Shekarabi, Aliakbar Amirzargar   +7 more
doaj   +1 more source

IL-2 Therapy Diminishes Renal Inflammation and the Activity of Kidney-Infiltrating CD4+ T Cells in Murine Lupus Nephritis [PDF]

, 2019
An acquired deficiency of interleukin-2 (IL-2) and related disturbances in regulatory T cell (Treg) homeostasis play an important role in the pathogenesis of systemic lupus erythematosus (SLE).
Burmester, Gerd-Rüdiger, Enghard, Philipp, Humrich, Jens, Kloke, Lutz, Kühl, Anja, Riemekasten, Gabriela, Rose, Angelika, von Spee-Mayer, Caroline, Wu, Kaiyin   +8 more
core   +2 more sources

GP96: safeguarding Treg

Oncotarget, 2015
FOXP3 positive regulatory T cells (Tregs) are key players in maintaining peripheral immune tolerance. Multiple molecules and signaling pathways are involved in regulating Treg function. Understanding these mechanisms is vital to designing Treg-targeted immunotherapeutic strategies for cancer and other diseases. A recent study uncovered that endoplasmic
Yongliang, Zhang, Ephraim, Ansa-Addo, Zihai, Li   +2 more
openaire   +2 more sources

Metabolic regulation of regulatory T cell development and function [PDF]

, 2014
It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require ATP-generating processes, whereas proliferating Teff require high metabolic flux through growth ...
Alves, Barbi, Battaglia, Bental, Borsellino, Carr, Cipolletta, Cobbold, Coloff, Cunningham, Curti, Cybulski, Dang, Deiuliis, Delgoffe, Delgoffe, Feuerer, Fisson, Fox, Frauwirth, GabryÅ¡ová, Greiner, Guertin, Guertin, Gulen, Hardie, Hardie, Howie, Hörig, Jacobs, Jones, Jordan, Kane, Lee, Lord, Makki, Matarese, Matteoli, Mellor, Metz, Michalek, Munder, Munder, Oh, Olefsky, Ouchi, Peter, Powell, Powell, Powell, Powell, Procaccini, Procaccini, Sakaguchi, Sarbassov, Shevach, Shi, Sitkovsky, Smith, Thornton, Vanasek, Vander Heiden, Vukmanovic-Stejic, Waickman, Wieman, Winer, Yang, Zeng, Zheng   +68 more
core   +2 more sources

Increased Plasticity of FOXP3+ Treg under Pathological Conditions Convert Treg into Either Novel Treg or Th1‐Treg

The FASEB Journal, 2018
Naïve CD4+ Th (T helper cells) can differentiate/be polarized in to 9 terminally differentiated Th cell subsets depending on the cytokine repertoire and anatomical location. CD4+ FOXP3+ (forkhead box P3) regulatory T cells (Treg) are one of the Th subsets.
Keman Xu, William Y. Yang, Gayani K. Nanayakkara, Ying Shao, Fan Yang, Wenhui Hu, Eric T. Choi, Hong Wang, Xiaofeng Yang   +8 more
openaire   +1 more source

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127pos Depletion, Treg Expansion, and Treg Cryopreservation

PLoS ONE, 2008
Treg based immunotherapy is of great interest to facilitate tolerance in autoimmunity and transplantation. For clinical trials, it is essential to have a clinical grade Treg isolation protocol in accordance with Good Manufacturing Practice (GMP) guidelines.
Peters, J.H., Preijers, F.W.M.B., Woestenenk, R.M., Hilbrands, L.B., Koenen, H.J.P.M., Joosten, I.   +5 more
openaire   +5 more sources

Recirculating IL-1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions [PDF]

Cellular & Molecular Immunology, 2020
The vast majority of Foxp3+ regulatory T cells (Tregs) are generated in the thymus, and several factors, such as cytokines and unique thymic antigen-presenting cells, are known to contribute to the development of these thymus-derived Tregs (tTregs).
Eirini Nikolouli, Yassin Elfaki, Susanne Herppich, Carsten Schelmbauer, Michael Delacher, Christine Falk, Ilgiz A. Mufazalov, Ari Waisman, Markus Feuerer, Jochen Huehn   +9 more
openaire   +3 more sources

Tregs and transplantation tolerance [PDF]

Journal of Clinical Investigation, 2004
The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes ...
Patrick T, Walsh, Devon K, Taylor, Laurence A, Turka   +2 more
openaire   +4 more sources