Results 71 to 80 of about 49,489 (310)

Novel protein contact points among TP53 and minichromosome maintenance complex proteins 2, 3, and 5

Cancer Medicine, Volume 11, Issue 24, Page 4989-5000, December 2022., 2022
Using a next‐generation sequencing‐based protein‐protein interaction method, we identified interactions among MCM2, MCM3, and MCM5. While many of the interacting regions we detected overlap with existing structural data of the complex, we also recovered novel domains with higher resolution.
Stephanie Schaefer‐Ramadan, Jovana Aleksic, Nayra M. Al‐Thani, Joel A. Malek   +3 more
wiley   +1 more source

Near‐Zero Thermal Expansion in Coordination Polymer Cd(1,2,4‐Triazole)2(H2PO4)2

Angewandte Chemie, EarlyView.
The structural dynamics and the chemical bonding origin of a volumetric near‐zero thermal expansion in a coordination polymer across 25 K to 400 K is studied using multi‐temperature X‐ray crystallography and X‐ray electron density analysis. The lattice expansion in the a and c directions is counteracted by contraction along b axis, caused by concerted ...
Sounak Sarkar, Bo Brummerstedt Iversen
wiley   +2 more sources

Synthesis and anticancer activity of podophyllotoxin derivatives with nitrogen-containing heterocycles

Frontiers in Chemistry, 2023
Three series of podophyllotoxin derivatives with various nitrogen-containing heterocycles were designed and synthesized. The antitumor activity of these podophyllotoxin derivatives was evaluated in vitro against a panel of human tumor cell lines.
Meng Yin, Yongsheng Fang, Xiaotong Sun, Minggao Xue, Caimei Zhang, Zhiyun Zhu, Yamiao Meng, Lingmei Kong, Yi Yi Myint, Yan Li, Jingfeng Zhao, Xiaodong Yang   +11 more
doaj   +1 more source

Half-Sandwich Ir(III) and Os(II) Complexes of Pyridyl-Mesoionic Carbenes as Potential Anticancer Agents [PDF]

, 2019
A series of cationic chlorido arene-iridium(III) and arene-osmium(II) complexes with bidentate pyridyl functionalized mesoionic carbenes (MIC) of the 1,2,3-triazol-5-ylidene type have been prepared.
Bolje, Aljoša, Brozović, Anamaria, Gržan, Tena, Hohloch, Stephan, Košmrlj, Janez, Kralj, Juran, Osmak, Maja, Sarkar, Biprajit, Steiner, Ivana, Stojanović, Nikolina, Stupin Polančec, Darija, Tupek, Ana, Urankar, Damijana   +12 more
core   +1 more source

Thermally Activated Delayed Fluorescence and Beyond. Photophysics and Material Design Strategies.

Advanced Photonics Research, EarlyView.
Photophysical properties of TADF molecules are determined by characteristic parameters that are discussed in detail(. Moreover, using femtosecond time‐resolved spectroscopy, quantum mechanical considerations, and state‐of‐art calculations, deeper understanding allows us to design breakthrough Cu(I) and organic TADF‐ OLED materials. For the latter ones,
Hartmut Yersin, Uwe Monkowius
wiley   +1 more source

Low‐Symmetry Face‐Capped Fe(II) Tetrahedra Through Anisotropic Ligand Extension

Angewandte Chemie, EarlyView.
A strategy for the formation of low‐symmetry face‐capped Fe(II) tetrahedra using anisotropic ligand extension is reported. The degree of distortion in the resulting tetrahedra correlates to the stability of the assemblies and the oxidation potentials of their metal ions. Abstract Low‐symmetry cages are attractive metallo‐supramolecular targets, as they
Jacob A. Gome, Zack T. Avery, Nina R. Lawson, Oliver G. Stansfield, Jack D. Evans, Michael G. Gardiner, Timothy U. Connell, Dan Preston   +7 more
wiley   +2 more sources

Synthesis of Carvone-Derived 1,2,3-Triazoles Study of Their Antioxidant Properties and Interaction with Bovine Serum Albumin

Molecules, 2018
Natural L-carvone was utilized as a starting material for an efficient synthesis of some terpenyl-derived 1,2,3-triazoles. Chlorination of carvone, followed by nucleophilic substitution with sodium azide resulted in the preparation of 10-azidocarvone ...
Armen S. Galstyan, Armen I. Martiryan, Karine R. Grigoryan, Armine G. Ghazaryan, Melanya A. Samvelyan, Tariel V. Ghochikyan, Valentine G. Nenajdenko   +6 more
doaj   +1 more source

Kinetics and mechanism of organocatalytic aza-Michael additions: direct observation of enamine intermediates. [PDF]

, 2012
The imidazoles 1a–g add to the CC-double bond of the iminium ion 2 with rate constants as predicted by the equation log k = sN(N + E). Unfavourable proton shifts from the imidazolium unit to the enamine fragment in the adduct 3 account for the failure of
Ahrendt, Albery, Almaşi, Baidya, Brazier, Brotzel, Diner, Dominguez de Maria, Enders, Erkkilä, Grošelj, Herbert Mayr, Komisarska, Lakhdar, Lakhdar, Lelais, List, List, MacMillan, Mahiuddin Baidya, Marcus, Mayr, Mayr, Mayr, Mayr, Mayr, Sami Lakhdar, Schmid, Schmid, Schmid, Seayad, Seebach, Tsogoeva, Uria   +33 more
core   +1 more source

Effective and Practical Stereoselective Synthesis of Nutlins Precursors by Immobilization of Privileged Chiral Mono‐Amidine Catalyst

Advanced Synthesis &Catalysis, EarlyView.
Abstract A strategy for the immobilization of Johnston's Mono(AMidine) catalyst (MAM) onto polystyrene, silica and hybrid silica‐polystyrene nanoparticles is presented. The catalyst activity was evaluated in the stereoselective aza‐Henry reaction leading to the pivotal β‐amino nitroalkane precursors of the anti‐cancer agents Nutlins (with Nutlin‐3a as ...
Sofia Toldo, Lorenzo Poletti, Graziano Di Carmine, Olga Bortolini, Carmela De Risi, Simona Felletti, Greta Compagnin, Alessandro Massi, Daniele Ragno   +8 more
wiley   +1 more source

TBADT‐Mediated C‐C Bond Formation Exploiting Aryl Aldehydes in a Photochemical Flow Reactor

ChemCatChem, Volume 15, Issue 2, January 20, 2023., 2023
Scaled Photochemical Reactions: A continuous flow approach for the photochemical synthesis of β‐ketonitriles and related species is presented. This approach tolerates (hetero)aromatic substrates and uses readily available TBADT as an effective HAT catalyst reaching throughputs of up to 41 mmol/h.
Adam Cruise, Marcus Baumann
wiley   +1 more source