Results 71 to 80 of about 2,567 (176)
Acta Physiologica, Volume 241, Issue 8, August 2025.ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth +2 more
wiley +1 more source
Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. [PDF]
, 2012 International audienceABSTRACT: The Blood--brain barrier (BBB), present at the level of the endothelium of cerebral blood vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is mandatory for cerebral homeostasis and ...
Artus, Cédric +4 more
core +4 more sources
Macronutrients as Regulators of Intestinal Epithelial Permeability: Where Do We Stand?
Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 3, May 2025.ABSTRACT The intestinal barrier function (IBF) is essential for intestinal homeostasis. Its alterations have been linked to intestinal and systemic disease. Regulation of intestinal permeability is key in the maintenance of the IBF, in which the intestinal epithelium and tight junctions, the mucus layer, sIgA, and antimicrobial peptides are important ...
Olga Martínez‐Augustin +9 more
wiley +1 more source
Toxins, 2018 Impaired growth, immunity, and intestinal barrier in mammals, poultry, and carp have been attributed to the mycotoxin deoxynivalenol (DON). The increased use of plant ingredients in aquaculture feed implies a risk for contamination with mycotoxins.
Torfinn Moldal +4 more
doaj +1 more source
4D pathology: translating dynamic epithelial tubulogenesis to prostate cancer pathology
Histopathology, Volume 86, Issue 5, Page 681-693, April 2025.Rethinking prostate cancer growth patterns in the context of epithelial tubule formation, elongation, and branching. The Gleason score is the gold standard for grading of prostate cancer (PCa) and is assessed by assigning specific grades to different microscopical growth patterns.
Hridya Harikumar +2 more
wiley +1 more source
Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer [PDF]
, 2014 The epithelial-to-mesenchymal transition (EMT) transcriptional program is characterized by repression of E-cadherin (CDH1) and induction of N-cadherin (CDH2), and mesenchymal genes like vimentin (VIM).
Alina Starchenko +32 more
core +2 more sources
Angulins and the Tricellular Tight Junction: Role in Inflammatory Bowel Diseases [PDF]
, 2021 The tight junction (TJ) protects the intestinal barrier function and controls the paracellular transport of water, ions, small water-soluble molecules, and macromolecules. The structure of the TJ comprises the belt-like meshwork of the TJ strands between
Hu, Jiachen
core +1 more source
Systematic review: The gut microbiota as a link between colorectal cancer and obesity
Obesity Reviews, Volume 26, Issue 4, April 2025.Summary Microbiome modulation is one of the novel strategies in medicine with the greatest future to improve the health of individuals and reduce the risk of different conditions, including metabolic, immune, inflammatory, and degenerative diseases, as well as cancer.
Antonio Jesús Ruiz‐Malagón +5 more
wiley +1 more source
Role of tight junctions in signal transduction: an update [PDF]
, 2014 Tight junctions (TJs), which are the most apically located of the intercellular junctional complexes, have a barrier function and a fence function. Recent studies show that they also participate in signal transduction mechanisms.
Himi, Tetsuo +3 more
core
Pathophysiology of IBD as a Key Strategy for Polymeric Nanoparticle Development
Advanced Therapeutics, Volume 8, Issue 3, March 2025.Polymeric nanoparticles are a promising approach for targeted drug delivery in case of patients with inflammatory bowel disease (IBD). IBD is a complex chronic gastrointestinal disease with compromised gastrointestinal barrier integrity, mucosal barrier alterations, altered cell surface receptor patterns, and oxidative stress. This review discusses how
Elena Gardey +2 more
wiley +1 more source