Results 221 to 230 of about 65,940 (289)

SnapShot: Mammalian TRP Channels

Cell, 2007
openaire   +2 more sources

Fasting and Caloric Restriction Activate an ADIOL‐NHR‐91‐Kynurenine Pathway Signaling Axis to Promote Healthspan

Aging Cell, Volume 25, Issue 5, May 2026.
The steroid hormone ADIOL emerges as a key mediator of fasting–and caloric restriction–induced healthspan benefits in C. elegans. These regimens activate ADIOL production, which acts through the estrogen receptor β homolog NHR‐91 to reduce neural kynurenic acid levels and enhance healthspan independently of lifespan. ADIOL supplementation, even late in
Ana Guijarro‐Hernández, Shinja Yoo, George A. Lemieux, Sena Komatsu, Abdullah Q. Latiff, Rishika R. Patil, Kaveh Ashrafi   +6 more
wiley   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

TRP channels: a provocative rationalization for local Ca²⁺ control in arterial tone development. [PDF]

Front Physiol
El-Lakany MA, Welsh DG.
europepmc   +1 more source

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

Emerging Techniques for the Extraction and Enzymatic Hydrolysis of Plant Proteins From Waste: An Integrative Review

Journal of Food Process Engineering, Volume 49, Issue 5, May 2026.
The graphical abstract presents plant protein sources and emerging extraction and enzymatic hydrolysis techniques, highlighting innovative technologies to increase yield, preserve nutritional quality, and generate hydrolysates and bioactive peptides with potential health benefits and sustainable industrial applications. ABSTRACT The growth of the world
Lara Louzada Aguiar, Roberta Soares Cabral, Vinícius Serafim Coelho, Bruna Vieira Nunes, Viviane Dias Medeiros Silva, Gabriel Barbosa de Oliveira, Renata Adriana Labanca, Julio Onesio‐Ferreira Melo, Raquel Linhares Bello de Araújo   +8 more
wiley   +1 more source

The Wheat CRK‐RLCK‐MAPKs Signalling Module Confers High‐Temperature All‐Stage Resistance to Stripe Rust

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2988-3008, May 2026.
ABSTRACT As global warming continues, rising temperatures significantly alter the interactions between wheat and the stripe rust pathogen Puccinia striiformis f. sp. tritici (Pst). Utilising high‐temperature all‐stage (HTAS) resistance to Pst is a novel strategy for breeding climate and disease resilient wheat cultivars.
Yifeng Shi, Yue Xu, Hai Li, Meng Fu, Xu Liu, Yuxiang Li, Xiaoping Hu   +6 more
wiley   +1 more source

The PagDMG6341–PagWD40–PagPOLD4 Module Coordinates Base Excision Repair in ‘84K’ Poplar (Populus alba × P. glandulosa)

Plant Biotechnology Journal, Volume 24, Issue 5, Page 2956-2969, May 2026.
ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling, Yijia Jin, Yufei Xia, Shenxiu Jiang, Jianghai Shu, Xiaotong Hu, Kang Du, Pingdong Zhang, Xiangyang Kang   +8 more
wiley   +1 more source

Role of thermosensitive transient receptor potential (TRP) channels in thermal preference of male and female mice. [PDF]

J Therm Biol
Carstens MI, Mahroke A, Selescu T, Carstens E.   +3 more
europepmc   +1 more source