Results 121 to 130 of about 2,132 (150)
Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages [PDF]
Journal of Cell Biology, 2020 Phagocytes use their actomyosin cytoskeleton to migrate as well as to probe their environment by phagocytosis or macropinocytosis. Although migration and extracellular material uptake have been shown to be coupled in some immune cells, the mechanisms involved in such coupling are largely unknown.
Floris Bosveld +2 more
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Schistosome TRPML channels play a role in neuromuscular activity and tegumental integrity
Biochimie, 2022Schistosomiasis is a neglected tropical disease caused by parasitic flatworms of the genus Schistosoma. Mono-therapeutic treatment of this disease with the drug praziquantel, presents challenges such as inactivity against immature worms and inability to prevent reinfection. Importantly, ion channels are important targets for many current anthelmintics.
Swarna Bais +2 more
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A Structural Overview of TRPML1 and the TRPML Family
2022This chapter explores the existing structural and functional studies on the endo-lysosomal channel TRPML1 and its analogs TRPML2, TRPML3. These channels represent the mucolipin subfamily of the TRP channel superfamily comprising important roles in sensory physiology, ion homeostasis, and signal transduction.
Michael, Fine, Xiaochun, Li
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European Journal of Medicinal Chemistry, 2021
The members of the TRPML subfamily of non-selective cation channels (TRPML1-3) are involved in the regulation of important lysosomal and endosomal functions, and mutations in TRPML1 are associated with the neurodegenerative lysosomal storage disorder mucolipidosis type IV. For in-depth investigation of functions and (patho)physiological roles of TRPMLs,
Nicole Urban +2 more
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The members of the TRPML subfamily of non-selective cation channels (TRPML1-3) are involved in the regulation of important lysosomal and endosomal functions, and mutations in TRPML1 are associated with the neurodegenerative lysosomal storage disorder mucolipidosis type IV. For in-depth investigation of functions and (patho)physiological roles of TRPMLs,
Nicole Urban +2 more
exaly +3 more sources
Gene expression of TRPMLs and its regulation by pathogen stimulation
Gene, 2023The transient receptor potential mucolipin (TRPML) subfamily in mammalian has three members, namely TRPML1, TRPML2, and TRPML3, who play key roles in regulating intracellular Ca2+ homeostasis, endosomal pH, membrane trafficking and autophagy. Previous studies had shown that three TRPMLs are closely related to the occurrence of pathogen invasion and ...
Zhiqiang, Xia +4 more
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TRPML Channels in Function, Disease, and Prospective Therapies
Methods in Pharmacology and Toxicology, 2012David A Zeevi
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Two-pore and TRPML cation channels: Regulators of phagocytosis, autophagy and lysosomal exocytosis
Pharmacology & Therapeutics, 2021The old Greek saying "Panta Rhei" ("everything flows") is true for all life and all living things in general. It also becomes nicely evident when looking closely into cells. There, material from the extracellular space is taken up by endocytic processes and transported to endosomes where it is sorted either for recycling or degradation.
Christian Grimm
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Endolysosomal Cation Channels as Therapeutic Targets—Pharmacology of TRPML Channels
Messenger (Los Angeles, Calif: Print), 2016Christian Grimm
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TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?
Cell Calcium, 2022Neurodegenerative diseases (ND) pose a serious health burden to society and healthcare systems alike, with increasing incidence rates especially within aging populations. Alzheimer's disease (AD) is the most prevalent type of ND or dementia, followed by Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's ...
Einar, Krogsaeter +2 more
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Cellular and molecular function of mucolipins (TRPML) and polycystin 2 (TRPP2)
Pflügers Archiv - European Journal of Physiology, 2005Mucolipins (transient receptor potential mucolipin, TRPML) and polycystin-2 proteins (transient receptor potential polycystin, TRPP) constitute two small families of cation channels with motif and sequence similarities to the transient receptor potential (TRP) class of non-selective cation channels. Genetic defects in TRPML1 and TRPML3 in humans and in
Feng, Qian, Konrad, Noben-Trauth
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